Ptgir MGI Mouse Gene Detail - MGI:99535 - prostaglandin I receptor (IP)

Symbol

Ptgir
Name

prostaglandin I receptor (IP)
Synonyms

IP, prostacyclin receptor

Feature Type

protein coding gene
IDs

MGI:99535
NCBI Gene: 19222
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr7:16640442-16644828 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 9.15 cM
Mapping Data

3 experiments

SNPs within 2kb

200 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_99535	protein coding gene	Chr7:16640415-16644830 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0031722	protein coding gene	Chr7:14673559-14677970 (+)
A/J	MGP_AJ_G0031694	protein coding gene	Chr7:14387671-14392086 (+)
AKR/J	MGP_AKRJ_G0031619	protein coding gene	Chr7:14729158-14733573 (+)
BALB/cJ	MGP_BALBcJ_G0031701	protein coding gene	Chr7:14495581-14499996 (+)
C3H/HeJ	MGP_C3HHeJ_G0031423	protein coding gene	Chr7:14913513-14917924 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0032167	protein coding gene	Chr7:15402254-15406669 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0029246	protein coding gene	Chr7:15924193-15928566 (+)
CAST/EiJ	MGP_CASTEiJ_G0030774	protein coding gene	Chr7:11689050-11693466 (+)
CBA/J	MGP_CBAJ_G0031382	protein coding gene	Chr7:15918999-15923410 (+)
DBA/2J	MGP_DBA2J_G0031538	protein coding gene	Chr7:14279538-14283953 (+)
FVB/NJ	MGP_FVBNJ_G0031494	protein coding gene	Chr7:14179980-14184395 (+)
LP/J	MGP_LPJ_G0031623	protein coding gene	Chr7:14908839-14913250 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0031529	protein coding gene	Chr7:15838776-15843191 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0032196	protein coding gene	Chr7:14507192-14511607 (+)
PWK/PhJ	MGP_PWKPhJ_G0030498	protein coding gene	Chr7:11799654-11804065 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0030325	protein coding gene	Chr7:9429751-9434140 (+)
WSB/EiJ	MGP_WSBEiJ_G0030871	protein coding gene	Chr7:14574015-14578430 (+)

Human Ortholog

PTGIR, prostaglandin I2 receptor

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PTGIR, prostaglandin I2 receptor
Synonyms

IP, PRIPR
Links

HGNC:9602

NCBI Gene ID: 5739

neXtProt AC: NX_P43119

UniProt: P43119
Chr Location

19q13.32; chr19:46610687-46625089 (-) GRCh38

MGI Vertebrate Homology

Ptgir stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PTGIR
Gene Tree

Ptgir

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Phenotype Summary

15 phenotypes from 1 allele in 3 genetic backgrounds
1 phenotype from multigenic genotypes
50 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Endonuclease-mediated

4
Targeted

1
Incidental Mutations

Mutagenetix
Find Mice (IMSR)

32 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygotes for a targeted null mutation exhibit increased susceptibility to thrombosis and injury-induced vascular proliferation, and decreased inflammatory and pain responses.

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All GO Annotations

17
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

798
Tissues

45
cDNA Data

10
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN ptgir

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All Sequences

39
RefSeq

4
UniProt

5
CCDS

CCDS20857.2

Ensembl

ENSMUSG00000043017 (Evidence)
NCBI Gene

19222

			Length	Strain/Species	Flank
genomic	19222	NCBI Gene Model \| MGI Sequence Detail	4387	C57BL/6J	± kb
transcript	NM_008967	RefSeq \| MGI Sequence Detail	3305	ZRU/MplStud
polypeptide	P43252	UniProt \| EBI \| MGI Sequence Detail	415	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000001655 prostacyclin receptor

(term hierarchy)
PDB

4F8K
InterPro Domains

IPR017452 GPCR, rhodopsin-like, 7TM

IPR000276 G protein-coupled receptor, rhodopsin-like

IPR000370 Prostacyclin (prostanoid IP) receptor

IPR008365 Prostanoid receptor
GlyGen

P43252 1 site

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All nucleic 12

Genomic 1

cDNA 10

Primer pair 1

Microarray probesets 3

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MGD-MRK-16313

Summaries

All 86

Developmental Gene Expression 3

Gene Ontology 7

Phenotypes 50
Earliest

J:17520 Namba T, et al., cDNA cloning of a mouse prostacyclin receptor. Multiple signaling pathways and expression in thymic medulla. J Biol Chem. 1994 Apr 1;269(13):9986-92
Latest

J:353367 Taketomi Y, et al., Lipid-orchestrated paracrine circuit coordinates mast cell maturation and anaphylaxis through functional interaction with fibroblasts. Immunity. 2024 Aug 13;57(8):1828-1847.e11

TSS for Ptgir:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr64653	Chr7:16639896-16639938 (+)	-525 bp
Tssr64654	Chr7:16640413-16640464 (+)	-3 bp
Tssr64655	Chr7:16640949-16640958 (+)	512 bp
Tssr64656	Chr7:16641980-16642013 (+)	1,555 bp
Tssr64657	Chr7:16642641-16642660 (+)	2,209 bp
Tssr64658	Chr7:16644403-16644415 (+)	3,967 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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