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Tal2 Gene Detail
Summary
  • Symbol
    Tal2
  • Name
    T cell acute lymphocytic leukemia 2
  • Synonyms
    bHLHa19
  • Feature Type
    protein coding gene
  • IDs
    MGI:99540
    NCBI Gene: 21350
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:53779705-53788712 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 28.75 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    382 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99540
 protein coding gene Chr4:53779701-53788712 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028302
 protein coding gene Chr4:52427287-52439769 (+)
A/J MGP_AJ_G0028263
 protein coding gene Chr4:50412788-50421625 (+)
AKR/J MGP_AKRJ_G0028212
 protein coding gene Chr4:51786770-51801122 (+)
BALB/cJ MGP_BALBcJ_G0028282
 protein coding gene Chr4:50598999-50607765 (+)
C3H/HeJ MGP_C3HHeJ_G0028003
 protein coding gene Chr4:52339798-52349953 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028723
 protein coding gene Chr4:54348235-54361851 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026031
 protein coding gene Chr4:47370683-47379222 (+)
CAST/EiJ MGP_CASTEiJ_G0027441
 protein coding gene Chr4:51990313-51999863 (+)
CBA/J MGP_CBAJ_G0027968
 protein coding gene Chr4:56206561-56220669 (+)
DBA/2J MGP_DBA2J_G0028118
 protein coding gene Chr4:50384267-50394889 (+)
FVB/NJ MGP_FVBNJ_G0028085
 protein coding gene Chr4:49617905-49626947 (+)
LP/J MGP_LPJ_G0028217
 protein coding gene Chr4:52535874-52546506 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028109
 protein coding gene Chr4:59407226-59418572 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028759
 protein coding gene Chr4:52023472-52033373 (+)
PWK/PhJ MGP_PWKPhJ_G0027166
 protein coding gene Chr4:50328298-50337458 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026994
 protein coding gene Chr4:51308193-51316605 (+)
WSB/EiJ MGP_WSBEiJ_G0027519
 protein coding gene Chr4:51927337-51937632 (+)



Homology
more
  • Human Ortholog
    TAL2, TAL bHLH transcription factor 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TAL2, TAL bHLH transcription factor 2
  • Links
    NCBI Gene ID: 6887
    neXtProt AC: NX_Q16559
    UniProt: Q16559

  • Chr Location
    9q31.2; chr9:105662457-105663124 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human TAL2 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    14 phenotypes from 2 alleles in 2 genetic backgrounds
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in growth retardation and lethality before reaching reproductive age. Mice exhibit brain abnormalities including a small superior colliculus and progressive hydrocephalus.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    941
  • Tissues
    149
  • cDNA Data
    12
  • Literature Summary
    21
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028417 Ensembl Gene Model | MGI Sequence Detail 9008 C57BL/6J ±  kb
    transcript ENSMUST00000030124 Ensembl | MGI Sequence Detail 2971 Not Applicable  
    polypeptide ENSMUSP00000030124 Ensembl | MGI Sequence Detail 108 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000016044 T-cell acute lymphocytic leukemia protein 2
      (term hierarchy)
    • InterPro Domains
      IPR036638 Helix-loop-helix DNA-binding domain superfamily
      IPR040238 Helix-loop-helix protein TAL-like
      IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
    Molecular
    Reagents
    less
    • All nucleic 16
      Genomic 2
      cDNA 12
      Primer pair 2

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-16318
    References
    more
    • Summaries
      All 53
      Developmental Gene Expression 21
      Gene Ontology 4
      Phenotypes 7
    • Earliest
      J:19155 Xia Y, et al., TAL2, a helix-loop-helix gene activated by the (7;9)(q34;q32) translocation in human T-cell leukemia. Proc Natl Acad Sci U S A. 1991 Dec 15;88(24):11416-20
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory