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Pde4d Gene Detail
Summary
  • Symbol
    Pde4d
  • Name
    phosphodiesterase 4D, cAMP specific
  • Synonyms
    9630011N22Rik, Dpde3, dunce
  • Feature Type
    protein coding gene
  • IDs
    MGI:99555
    NCBI Gene: 238871
  • Alliance
    gene page
  • Transcription Start Sites
    43 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:108790711-110092503 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 59.69 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    37780 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99555
 protein coding gene Chr13:108586482-110092503 (+)
129S1/SvImJ MGP_129S1SvImJ_G0020927
 protein coding gene Chr13:110761069-112335382 (+)
A/J MGP_AJ_G0020876
 protein coding gene Chr13:106401791-107898773 (+)
AKR/J MGP_AKRJ_G0020852
 protein coding gene Chr13:109614648-111158354 (+)
BALB/cJ MGP_BALBcJ_G0020877
 protein coding gene Chr13:107126548-108607285 (+)
C3H/HeJ MGP_C3HHeJ_G0020666
 protein coding gene Chr13:109402103-110932307 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021312
 protein coding gene Chr13:114091893-115714083 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018881
 protein coding gene Chr13:101862598-103291495 (+)
CAST/EiJ MGP_CASTEiJ_G0020185
 protein coding gene Chr13:108937880-110504012 (+)
CBA/J MGP_CBAJ_G0020628
 protein coding gene Chr13:118487777-120157278 (+)
DBA/2J MGP_DBA2J_G0020751
 protein coding gene Chr13:106159017-107627819 (+)
FVB/NJ MGP_FVBNJ_G0020734
 protein coding gene Chr13:104813608-106304335 (+)
LP/J MGP_LPJ_G0020826
 protein coding gene Chr13:110833105-112423021 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020762
 protein coding gene Chr13:118882705-120560221 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021350
 protein coding gene Chr13:109086987-110609014 (+)
PWK/PhJ MGP_PWKPhJ_G0019938
 protein coding gene Chr13:104850051-106338308 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019760
 protein coding gene Chr13:105336062-106887682 (+)
WSB/EiJ MGP_WSBEiJ_G0020243
 protein coding gene Chr13:109635518-111181908 (+)



Homology
more
  • Human Ortholog
    PDE4D, phosphodiesterase 4D
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PDE4D, phosphodiesterase 4D
  • Synonyms
    ACRDYS2, DPDE3, HSPDE4D, PDE43, PDE4DN2, STRK1
  • Links
    NCBI Gene ID: 5144
    neXtProt AC: NX_Q08499
    UniProt: Q08499

  • Chr Location
    5q11.2-q12.1; chr5:58969038-60522128 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human PDE4D associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 2 alleles in 4 genetic backgrounds
    2 phenotypes from multigenic genotypes
    2 images
    38 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit delayed growth, female infertility associated with impaired ovulation, and reduced postnatal viability.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    83
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    882
  • Tissues
    138
  • cDNA Data
    21
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 238871 NCBI Gene Model | MGI Sequence Detail 1301793 C57BL/6J ±  kb
    transcript NM_001402885 RefSeq | MGI Sequence Detail 7863 C57BL/6  
    polypeptide Q01063 UniProt | EBI | MGI Sequence Detail 747 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      17 Sequences
    • Protein Ontology
      PR:000012475 3',5'-cyclic-AMP phosphodiesterase 4D
      (term hierarchy)
    • EC
      3.1.4.-, 3.1.4.53
    • InterPro Domains
      IPR023088 3'5'-cyclic nucleotide phosphodiesterase
      IPR002073 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
      IPR036971 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily
      IPR023174 3'5'-cyclic nucleotide phosphodiesterase, conserved site
      IPR003607 HD/PDEase domain
      IPR040844 Phosphodiesterase 4 upstream conserved regions (UCR)
    • GlyGen
      Q01063 3 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 30
      cDNA 23
      Primer pair 4
      Other 3

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-16333, MGI:2145249, MGI:2444663
    References
    more
    • Summaries
      All 100
      Developmental Gene Expression 9
      Gene Ontology 16
      Phenotypes 38
    • Earliest
      J:2526 Repaske DR, et al., A polymerase chain reaction strategy to identify and clone cyclic nucleotide phosphodiesterase cDNAs. Molecular cloning of the cDNA encoding the 63-kDa calmodulin-dependent phosphodiesterase. J Biol Chem. 1992 Sep 15;267(26):18683-8
    • Latest
      J:333490 Gao R, et al., Phosphodiesterase 4D contributes to angiotensin II-induced abdominal aortic aneurysm through smooth muscle cell apoptosis. Exp Mol Med. 2022 Aug;54(8):1201-1213
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory