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Pde4b Gene Detail
Summary
  • Symbol
    Pde4b
  • Name
    phosphodiesterase 4B, cAMP specific
  • Synonyms
    Dpde4, dunce
  • Feature Type
    protein coding gene
  • IDs
    MGI:99557
    NCBI Gene: 18578
  • Alliance
    gene page
  • Transcription Start Sites
    44 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:101944740-102464456 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 46.99 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    14596 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99557
 protein coding gene Chr4:101944529-102464459 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028500
 protein coding gene Chr4:102436844-102995196 (+)
A/J MGP_AJ_G0028463
 protein coding gene Chr4:98867360-99406528 (+)
AKR/J MGP_AKRJ_G0028410
 protein coding gene Chr4:101243125-101813322 (+)
BALB/cJ MGP_BALBcJ_G0028482
 protein coding gene Chr4:99056373-99603938 (+)
C3H/HeJ MGP_C3HHeJ_G0028196
 protein coding gene Chr4:102040773-102596594 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028922
 protein coding gene Chr4:106295566-106880648 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026213
 protein coding gene Chr4:94258266-94777042 (+)
CAST/EiJ MGP_CASTEiJ_G0027632
 protein coding gene Chr4:99795133-100356929 (+)
CBA/J MGP_CBAJ_G0028165
 protein coding gene Chr4:109650984-110263186 (+)
DBA/2J MGP_DBA2J_G0028313
 protein coding gene Chr4:98541647-99068829 (+)
FVB/NJ MGP_FVBNJ_G0028280
 protein coding gene Chr4:97395748-97924065 (+)
LP/J MGP_LPJ_G0028414
 protein coding gene Chr4:102751487-103314140 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028307
 protein coding gene Chr4:115162664-115751506 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028957
 protein coding gene Chr4:101477887-102022115 (+)
PWK/PhJ MGP_PWKPhJ_G0027358
 protein coding gene Chr4:96740803-97275822 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027182
 protein coding gene Chr4:98898348-99454070 (+)
WSB/EiJ MGP_WSBEiJ_G0027712
 protein coding gene Chr4:101658025-102204559 (+)



Homology
more
  • Human Ortholog
    PDE4B, phosphodiesterase 4B
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PDE4B, phosphodiesterase 4B
  • Synonyms
    DPDE4, PDEIVB
  • Links
    NCBI Gene ID: 5142
    neXtProt AC: NX_Q07343
    UniProt: Q07343

  • Chr Location
    1p31.3; chr1:65792510-66374579 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human PDE4B associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    24 phenotypes from 3 alleles in 7 genetic backgrounds
    2 phenotypes from multigenic genotypes
    37 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene produce significantly less TNF-alpha in response to lipopolysaccharide stimulation. One mutation resulted in brain and spinal cord vacuoles.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    33
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    832
  • Tissues
    111
  • cDNA Data
    22
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028525 Ensembl Gene Model | MGI Sequence Detail 519717 C57BL/6J ±  kb
    transcript ENSMUST00000106911 Ensembl | MGI Sequence Detail 3020 Not Applicable  
    polypeptide ENSMUSP00000102524 Ensembl | MGI Sequence Detail 736 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      17 Sequences
    • EC
      3.1.4.-, 3.1.4.53
    • InterPro Domains
      IPR023088 3'5'-cyclic nucleotide phosphodiesterase
      IPR002073 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
      IPR036971 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily
      IPR023174 3'5'-cyclic nucleotide phosphodiesterase, conserved site
      IPR003607 HD/PDEase domain
      IPR040844 Phosphodiesterase 4 upstream conserved regions (UCR)
    • GlyGen
      B1AWC9 1 site, 1 N-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 46
      Genomic 16
      cDNA 24
      Primer pair 4
      Other 2

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-16335, MGI:2140715
    References
    more
    • Summaries
      All 86
      Developmental Gene Expression 8
      Gene Ontology 10
      Phenotypes 37
    • Earliest
      J:18405 Milatovich A, et al., Chromosome localizations of genes for five cAMP-specific phosphodiesterases in man and mouse. Somat Cell Mol Genet. 1994 Mar;20(2):75-86
    • Latest
      J:353655 Lipina TV, Li S, Petrova ES, Amstislavskaya TG, Cameron RT, Elliott C, Gondo Y, McGirr A, Mullins JGL, Baillie GS, Woodgett JR, Clapcote SJ, PDE4B Missense Variant Increases Susceptibility to Post-Traumatic Stress Disorder-Relevant Phenotypes in Mice. J Neurosci (Online). 2024;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory