Pde4a MGI Mouse Gene Detail - MGI:99558 - phosphodiesterase 4A, cAMP specific

Symbol

Pde4a
Name

phosphodiesterase 4A, cAMP specific
Synonyms

D9Ertd60e, Dpde2, dunce

Feature Type

protein coding gene
IDs

MGI:99558
NCBI Gene: 18577
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr9:21077010-21124544 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 7.73 cM
Mapping Data

4 experiments

SNPs within 2kb

1205 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_99558	protein coding gene	Chr9:21076998-21124544 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0034443	protein coding gene	Chr9:18354271-18405897 (+)
A/J	MGP_AJ_G0034421	protein coding gene	Chr9:18048223-18098375 (+)
AKR/J	MGP_AKRJ_G0034348	protein coding gene	Chr9:18376535-18423929 (+)
BALB/cJ	MGP_BALBcJ_G0034412	protein coding gene	Chr9:17941824-17989548 (+)
C3H/HeJ	MGP_C3HHeJ_G0034124	protein coding gene	Chr9:18680284-18731468 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0034933	protein coding gene	Chr9:19095160-19147194 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031863	protein coding gene	Chr9:17175707-17223857 (+)
CAST/EiJ	MGP_CASTEiJ_G0033447	protein coding gene	Chr9:18504604-18573039 (+)
CBA/J	MGP_CBAJ_G0034097	protein coding gene	Chr9:19811024-19863050 (+)
DBA/2J	MGP_DBA2J_G0034256	protein coding gene	Chr9:18025959-18073681 (+)
FVB/NJ	MGP_FVBNJ_G0034199	protein coding gene	Chr9:17544124-17595637 (+)
LP/J	MGP_LPJ_G0034341	protein coding gene	Chr9:18527901-18576664 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0034242	protein coding gene	Chr9:21418826-21472212 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0034953	protein coding gene	Chr9:18328679-18380366 (+)
PWK/PhJ	MGP_PWKPhJ_G0033153	protein coding gene	Chr9:18001539-18064928 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0032987	protein coding gene	Chr9:18387243-18447948 (+)
WSB/EiJ	MGP_WSBEiJ_G0033562	protein coding gene	Chr9:18054062-18104263 (+)

Human Ortholog

PDE4A, phosphodiesterase 4A

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PDE4A, phosphodiesterase 4A
Synonyms

DPDE2, PDE4, PDE46
Links

HGNC:8780

NCBI Gene ID: 5141

neXtProt AC: NX_P27815

UniProt: P27815
Chr Location

19p13.2; chr19:10416773-10469631 (+) GRCh38

MGI Vertebrate Homology

Pde4a stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PDE4A
Gene Tree

Pde4a

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Phenotype Summary

4 phenotypes from 2 alleles in 4 genetic backgrounds
2 phenotypes from multigenic genotypes
19 phenotype references

All Mutations and Alleles

29
Gene trapped

25
Targeted

4
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

39 strains or lines available

Homozygous null mice have a normal phenotype.

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All GO Annotations

34
GO References

13

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

853
Tissues

147
cDNA Data

31
Literature Summary

6

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase pde4a

ZFIN pde4a

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All Sequences

82
RefSeq

25
UniProt

8
CCDS

CCDS22895.1, CCDS22896.1, CCDS80964.1

Ensembl

ENSMUSG00000032177 (Evidence)
NCBI Gene

18577

			Length	Strain/Species	Flank
genomic	ENSMUSG00000032177	Ensembl Gene Model \| MGI Sequence Detail	47535	C57BL/6J	± kb
transcript	ENSMUST00000039413	Ensembl \| MGI Sequence Detail	4653	Not Applicable
polypeptide	ENSMUSP00000037025	Ensembl \| MGI Sequence Detail	844	Not Applicable

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UniProt

8 Sequences
Protein Ontology

PR:000012472 3',5'-cyclic-AMP phosphodiesterase 4A

(term hierarchy)
EC

3.1.4.-, 3.1.4.53
InterPro Domains

IPR023088 3'5'-cyclic nucleotide phosphodiesterase

IPR002073 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain

IPR036971 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily

IPR023174 3'5'-cyclic nucleotide phosphodiesterase, conserved site

IPR003607 HD/PDEase domain

IPR040844 Phosphodiesterase 4 upstream conserved regions (UCR)

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All nucleic 36

cDNA 32

Primer pair 3

Other 1

Microarray probesets 3

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MGD-MRK-16336, MGI:1098742

Summaries

All 67

Developmental Gene Expression 6

Gene Ontology 13

Phenotypes 19
Earliest

J:18405 Milatovich A, et al., Chromosome localizations of genes for five cAMP-specific phosphodiesterases in man and mouse. Somat Cell Mol Genet. 1994 Mar;20(2):75-86
Latest

J:320373 Boyd A, et al., Assessment of PDE4 Inhibitor-Induced Hypothermia as a Correlate of Nausea in Mice. Biology (Basel). 2021 Dec 20;10(12)

TSS for Pde4a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr83968	Chr9:21077016-21077058 (+)	27 bp
Tssr83969	Chr9:21079240-21079260 (+)	2,240 bp
Tssr83970	Chr9:21092867-21092920 (+)	15,884 bp
Tssr83971	Chr9:21095409-21095426 (+)	18,408 bp
Tssr83972	Chr9:21095468-21095482 (+)	18,465 bp
Tssr83973	Chr9:21095644-21095680 (+)	18,652 bp
Tssr83974	Chr9:21108018-21108067 (+)	31,033 bp
Tssr83975	Chr9:21112001-21112057 (+)	35,019 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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