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Drd1 Gene Detail
Summary
  • Symbol
    Drd1
  • Name
    dopamine receptor D1
  • Synonyms
    C030036C15Rik, D1 receptor, Drd-1, Drd1a, Gpcr15
  • Feature Type
    protein coding gene
  • IDs
    MGI:99578
    NCBI Gene: 13488
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:54205202-54209677 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 28.40 cM
  • Mapping Data
    15 experiments
Strain
Comparison
more
  • SNPs within 2kb
    174 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    4
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99578
 protein coding gene Chr13:54205202-54209724 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020564
 protein coding gene Chr13:53426209-53430675 (-)
A/J MGP_AJ_G0020518
 protein coding gene Chr13:51474846-51479305 (-)
AKR/J MGP_AKRJ_G0020496
 protein coding gene Chr13:52978949-52983422 (-)
BALB/cJ MGP_BALBcJ_G0020514
 protein coding gene Chr13:51696840-51701299 (-)
C3H/HeJ MGP_C3HHeJ_G0020313
 protein coding gene Chr13:52798746-52806804 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020948
 protein coding gene Chr13:55063010-55067482 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018530
 protein coding gene Chr13:49477166-49481617 (-)
CAST/EiJ MGP_CASTEiJ_G0019827
 protein coding gene Chr13:52865024-52870425 (-)
CBA/J MGP_CBAJ_G0020273
 protein coding gene Chr13:57144604-57149061 (-)
DBA/2J MGP_DBA2J_G0020396
 protein coding gene Chr13:51047101-51051726 (-)
FVB/NJ MGP_FVBNJ_G0020375
 protein coding gene Chr13:50494507-50498979 (-)
LP/J MGP_LPJ_G0020472
 protein coding gene Chr13:53697297-53701763 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020404
 protein coding gene Chr13:56667312-56672144 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020991
 protein coding gene Chr13:52579387-52583859 (-)
PWK/PhJ MGP_PWKPhJ_G0019583
 protein coding gene Chr13:51004163-51008608 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019410
 protein coding gene Chr13:51481244-51485689 (-)
WSB/EiJ MGP_WSBEiJ_G0019889
 protein coding gene Chr13:52908819-52913280 (-)



Homology
more
  • Human Ortholog
    DRD1, dopamine receptor D1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DRD1, dopamine receptor D1
  • Synonyms
    D1R, DADR, DRD1A
  • Links
    NCBI Gene ID: 1812
    neXtProt AC: NX_P21728
    UniProt: P21728

  • Chr Location
    5q35.2; chr5:175440036-175444182 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human DRD1 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    40 phenotypes from 8 alleles in 13 genetic backgrounds
    73 phenotypes from multigenic genotypes
    164 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted mutations show variably abnormalities that may include growth retardation, death after weaning unless given hydrated food, nonresponsiveness to dopamine D1 receptor agonists and antagonists, and normal to hyperactive locomotor activity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    191
  • GO References
    76
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    989
  • Tissues
    180
  • cDNA Data
    7
  • Literature Summary
    37
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 13488 NCBI Gene Model | MGI Sequence Detail 4476 C57BL/6J ±  kb
    transcript NM_010076 RefSeq | MGI Sequence Detail 3543 ZRU/MplStud  
    polypeptide Q61616 UniProt | EBI | MGI Sequence Detail 446 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 27
      Genomic 2
      cDNA 9
      Primer pair 5
      Other 11

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-16360, MGD-MRK-16387, MGD-MRK-8892, MGD-MRK-8896, MGI:1924787
    References
    more
    • Summaries
      All 368
      Developmental Gene Expression 37
      Diseases 1
      Gene Ontology 76
      Phenotypes 164
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:359175 Bonnavion P, et al., Striatal projection neurons coexpressing dopamine D1 and D2 receptors modulate the motor function of D1- and D2-SPNs. Nat Neurosci. 2024 Sep;27(9):1783-1793
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory