Arf2 MGI Mouse Gene Detail - MGI:99595

Symbol

Arf2
Name

ARF GTPase 2

Feature Type

protein coding gene
IDs

MGI:99595
NCBI Gene: 11841
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr11:103857565-103876163 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 67.64 cM, cytoband D
Mapping Data

3 experiments

SNPs within 2kb

490 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_99595	protein coding gene	Chr11:103857551-103876176 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019271	protein coding gene	Chr11:107089789-107110524 (+)
A/J	MGP_AJ_G0019239	protein coding gene	Chr11:102534275-102554391 (+)
AKR/J	MGP_AKRJ_G0019208	protein coding gene	Chr11:105681818-105700422 (+)
BALB/cJ	MGP_BALBcJ_G0019213	protein coding gene	Chr11:102970707-102989919 (+)
C3H/HeJ	MGP_C3HHeJ_G0019022	protein coding gene	Chr11:105910566-105930960 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019663	protein coding gene	Chr11:110397638-110419644 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017288	protein coding gene	Chr11:99942849-99962090 (+)
CAST/EiJ	MGP_CASTEiJ_G0018576	protein coding gene	Chr11:106937974-106957009 (+)
CBA/J	MGP_CBAJ_G0018991	protein coding gene	Chr11:114991645-115013123 (+)
DBA/2J	MGP_DBA2J_G0019103	protein coding gene	Chr11:102030035-102048746 (+)
FVB/NJ	MGP_FVBNJ_G0019094	protein coding gene	Chr11:101557700-101576193 (+)
LP/J	MGP_LPJ_G0019172	protein coding gene	Chr11:107570614-107590091 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019124	protein coding gene	Chr11:114316462-114337044 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019700	protein coding gene	Chr11:106066308-106087899 (+)
PWK/PhJ	MGP_PWKPhJ_G0018340	protein coding gene	Chr11:103117251-103136098 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018131	protein coding gene	Chr11:105821310-105839692 (+)
WSB/EiJ	MGP_WSBEiJ_G0018625	protein coding gene	Chr11:106069572-106088195 (+)

Human Ortholog

ARF2P, ARF GTPase 2, pseudogene

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ARF2P, ARF GTPase 2, pseudogene
Links

HGNC:44341

NCBI Gene ID: 108489980
Chr Location

17q21.31; chr17:45632945-45639402 (+) GRCh38

MGI Vertebrate Homology

Arf2 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: ARF2P
Gene Tree

Arf2

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Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

13
Gene trapped

9
Targeted

4
Find Mice (IMSR)

11 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

10
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

836
Tissues

49
cDNA Data

87
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN arf2a, arf2b

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All Sequences

49
RefSeq

4
UniProt

2
CCDS

CCDS25525.1

Ensembl

ENSMUSG00000062421 (Evidence)
NCBI Gene

11841

			Length	Strain/Species	Flank
genomic	ENSMUSG00000062421	Ensembl Gene Model \| MGI Sequence Detail	18599	C57BL/6J	± kb
transcript	ENSMUST00000063347	Ensembl \| MGI Sequence Detail	2660	Not Applicable
polypeptide	ENSMUSP00000102622	Ensembl \| MGI Sequence Detail	181	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000004575 ADP-ribosylation factor 2

(term hierarchy)
PDB

1J2J
InterPro Domains

IPR045872 ADP-ribosylation factor 1-5

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR006689 Small GTPase superfamily, ARF/SAR type

IPR024156 Small GTPase superfamily, ARF type

IPR005225 Small GTP-binding protein domain
GlyGen

Q8BSL7 1 site, 1 O-linked glycan (1 site)

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All nucleic 89

cDNA 88

Primer pair 1

Microarray probesets 4

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MGD-MRK-16377

Summaries

All 36

Developmental Gene Expression 5

Gene Ontology 4

Phenotypes 9
Earliest

J:18483 Schurmann A, et al., Cloning of two novel ADP-ribosylation factor-like proteins and characterization of their differential expression in 3T3-L1 cells. J Biol Chem. 1994 Jun 3;269(22):15683-8
Latest

J:346136 Matsuki T, et al., Expression analysis of type I ARF small GTPases ARF1-3 during mouse brain development. Mol Biol Rep. 2024 Jan 16;51(1):106

TSS for Arf2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr105365	Chr11:103857542-103857616 (+)	14 bp
Tssr105366	Chr11:103870428-103870452 (+)	12,875 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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