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Aldh2 Gene Detail
Summary
  • Symbol
    Aldh2
  • Name
    aldehyde dehydrogenase 2, mitochondrial
  • Synonyms
    Ahd-5, Ahd5
  • Feature Type
    protein coding gene
  • IDs
    MGI:99600
    NCBI Gene: 11669
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:121704090-121731887 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 61.86 cM, cytoband F-G1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1105 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99600
 protein coding gene Chr5:121704090-121731887 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030033
 protein coding gene Chr5:125066116-125098221 (-)
A/J MGP_AJ_G0029998
 protein coding gene Chr5:119911258-119948216 (-)
AKR/J MGP_AKRJ_G0029934
 protein coding gene Chr5:123789249-123821332 (-)
BALB/cJ MGP_BALBcJ_G0030009
 protein coding gene Chr5:121295902-121323630 (-)
C3H/HeJ MGP_C3HHeJ_G0029726
 protein coding gene Chr5:124365908-124394878 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030462
 protein coding gene Chr5:129824128-129853925 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027688
 protein coding gene Chr5:114587437-114614922 (-)
CAST/EiJ MGP_CASTEiJ_G0029135
 protein coding gene Chr5:123476849-123507597 (-)
CBA/J MGP_CBAJ_G0029696
 protein coding gene Chr5:134938399-134972891 (-)
DBA/2J MGP_DBA2J_G0029846
 protein coding gene Chr5:119979109-120006971 (-)
FVB/NJ MGP_FVBNJ_G0029802
 protein coding gene Chr5:118937725-118966487 (-)
LP/J MGP_LPJ_G0029935
 protein coding gene Chr5:125590073-125640292 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029833
 protein coding gene Chr5:138779564-138809865 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030503
 protein coding gene Chr5:123318975-123347494 (-)
PWK/PhJ MGP_PWKPhJ_G0028849
 protein coding gene Chr5:118753521-118782049 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028686
 protein coding gene Chr5:121063898-121092734 (-)
WSB/EiJ MGP_WSBEiJ_G0029210
 protein coding gene Chr5:123965179-123995566 (-)



Homology
more
  • Human Ortholog
    ALDH2, aldehyde dehydrogenase 2 family member
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ALDH2, aldehyde dehydrogenase 2 family member
  • Synonyms
    ALDH-E2, ALDHI, ALDM
  • Links
    NCBI Gene ID: 217
    neXtProt AC: NX_P05091
    UniProt: P05091

  • Chr Location
    12q24.12; chr12:111766887-111817532 (+)  GRCh38
Human Diseases
more
  • Diseases
    15 with human ALDH2 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
 View 1 model
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    49 phenotypes from 8 alleles in 9 genetic backgrounds
    43 phenotypes from multigenic genotypes
    3 images
    116 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in the absence of oxidation activity in the mitochondria. Mice homozygous for a different allele exhibit decreased litter size.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    829
  • Tissues
    108
  • cDNA Data
    611
  • Literature Summary
    15
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11669 NCBI Gene Model | MGI Sequence Detail 27798 C57BL/6J ±  kb
    transcript NM_009656 RefSeq | MGI Sequence Detail 3883 C57BL/6  
    polypeptide P47738 UniProt | EBI | MGI Sequence Detail 519 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 623
      Genomic 4
      cDNA 612
      Primer pair 6
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-1210, MGD-MRK-1217, MGD-MRK-16382
    References
    more
    • Summaries
      All 195
      Developmental Gene Expression 15
      Diseases 2
      Gene Ontology 11
      Phenotypes 116
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory