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Cntfr Gene Detail
Summary
  • Symbol
    Cntfr
  • Name
    ciliary neurotrophic factor receptor
  • Synonyms
    Cntfralpha
  • Feature Type
    protein coding gene
  • IDs
    MGI:99605
    NCBI Gene: 12804
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:41657498-41697089 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 21.81 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    569 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    3
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99605
 protein coding gene Chr4:41657498-41697091 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028167
 protein coding gene Chr4:39616563-39661837 (-)
A/J MGP_AJ_G0028125
 protein coding gene Chr4:38103864-38150121 (-)
AKR/J MGP_AKRJ_G0028088
 protein coding gene Chr4:39097540-39142094 (-)
BALB/cJ MGP_BALBcJ_G0028137
 protein coding gene Chr4:38439096-38499227 (-)
C3H/HeJ MGP_C3HHeJ_G0027865
 protein coding gene Chr4:39639500-39684160 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028578
 protein coding gene Chr4:41092125-41139175 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025919
 protein coding gene Chr4:35758588-35797846 (-)
CAST/EiJ MGP_CASTEiJ_G0027321
 protein coding gene Chr4:39317104-39377878 (-)
CBA/J MGP_CBAJ_G0027837
 protein coding gene Chr4:42476481-42521259 (-)
DBA/2J MGP_DBA2J_G0027981
 protein coding gene Chr4:38041072-38080750 (-)
FVB/NJ MGP_FVBNJ_G0027948
 protein coding gene Chr4:37355916-37400917 (-)
LP/J MGP_LPJ_G0028089
 protein coding gene Chr4:39685795-39752824 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027981
 protein coding gene Chr4:45771016-45814861 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028637
 protein coding gene Chr4:39205211-39251576 (-)
PWK/PhJ MGP_PWKPhJ_G0027040
 protein coding gene Chr4:38057958-38097787 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026867
 protein coding gene Chr4:38938240-38981266 (-)
WSB/EiJ MGP_WSBEiJ_G0027397
 protein coding gene Chr4:39191431-39236508 (-)



Homology
more
  • Human Ortholog
    CNTFR, ciliary neurotrophic factor receptor
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CNTFR, ciliary neurotrophic factor receptor
  • Links
    NCBI Gene ID: 1271
    neXtProt AC: NX_P26992
    UniProt: P26992

  • Chr Location
    9p13.3; chr9:34551432-34590852 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 4 alleles in 3 genetic backgrounds
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant animals exhibit a significant reduction in the number of motor neurons. Neonatal mutants fail to suckle and die within 24 hours after birth.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    35
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    820
  • Tissues
    97
  • cDNA Data
    19
  • Literature Summary
    15
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028444 Ensembl Gene Model | MGI Sequence Detail 39592 C57BL/6J ±  kb
    transcript ENSMUST00000102961 Ensembl | MGI Sequence Detail 1995 Not Applicable  
    polypeptide ENSMUSP00000100026 Ensembl | MGI Sequence Detail 372 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000005664 ciliary neurotrophic factor receptor subunit alpha
      (term hierarchy)
    • InterPro Domains
      IPR003961 Fibronectin type III
      IPR036116 Fibronectin type III superfamily
      IPR007110 Immunoglobulin-like domain
      IPR036179 Immunoglobulin-like domain superfamily
      IPR013783 Immunoglobulin-like fold
      IPR003599 Immunoglobulin subtype
      IPR003598 Immunoglobulin subtype 2
      IPR003530 Long hematopoietin receptor, soluble alpha chain, conserved site
      IPR050379 Type I Cytokine Receptor
    • GlyGen
      O88507 5 sites, 9 N-linked glycans (4 sites), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 32
      Genomic 3
      cDNA 22
      Primer pair 5
      Other 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-16390
    References
    more
    • Summaries
      All 74
      Developmental Gene Expression 15
      Gene Ontology 10
      Phenotypes 26
    • Earliest
      J:11178 Spies T, et al., Restored expression of major histocompatibility class I molecules by gene transfer of a putative peptide transporter [see comments]. Nature. 1991 May 23;351(6324):323-4
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory