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Zap70 Gene Detail
Summary
  • Symbol
    Zap70
  • Name
    zeta-chain (TCR) associated protein kinase
  • Synonyms
    Srk, TZK, ZAP-70
  • Feature Type
    protein coding gene
  • IDs
    MGI:99613
    NCBI Gene: 22637
  • Alliance
    gene page
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:36800912-36821899 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 15.41 cM, cytoband A4-C1
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    815 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99613
 protein coding gene Chr1:36800879-36821899 (+)
129S1/SvImJ MGP_129S1SvImJ_G0015932
 protein coding gene Chr1:35322765-35345120 (+)
A/J MGP_AJ_G0015916
 protein coding gene Chr1:34374511-34393215 (+)
AKR/J MGP_AKRJ_G0015871
 protein coding gene Chr1:34853921-34873471 (+)
BALB/cJ MGP_BALBcJ_G0015870
 protein coding gene Chr1:34053791-34072211 (+)
C3H/HeJ MGP_C3HHeJ_G0015703
 protein coding gene Chr1:35053402-35080277 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016323
 protein coding gene Chr1:36909783-36936765 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014045
 protein coding gene Chr1:31412797-31433758 (+)
CAST/EiJ MGP_CASTEiJ_G0015284
 protein coding gene Chr1:34942303-34964982 (+)
CBA/J MGP_CBAJ_G0015675
 protein coding gene Chr1:37892737-37920591 (+)
DBA/2J MGP_DBA2J_G0015776
 protein coding gene Chr1:33702663-33724091 (+)
FVB/NJ MGP_FVBNJ_G0015778
 protein coding gene Chr1:33226490-33248254 (+)
LP/J MGP_LPJ_G0015846
 protein coding gene Chr1:35693938-35713942 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0015798
 protein coding gene Chr1:40083949-40110796 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016370
 protein coding gene Chr1:34901178-34922247 (+)
PWK/PhJ MGP_PWKPhJ_G0015067
 protein coding gene Chr1:33459462-33482213 (+)
SPRET/EiJ MGP_SPRETEiJ_G0014849
 protein coding gene Chr1:34842363-34867246 (+)
WSB/EiJ MGP_WSBEiJ_G0015346
 protein coding gene Chr1:34849588-34874119 (+)



Homology
more
  • Human Ortholog
    ZAP70, zeta chain of T cell receptor associated protein kinase 70
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ZAP70, zeta chain of T cell receptor associated protein kinase 70
  • Synonyms
    ADMIO2, IMD48, SRK, STCD, STD, TZK, ZAP-70
  • Links
    NCBI Gene ID: 7535
    neXtProt AC: NX_P43403
    UniProt: P43403

  • Chr Location
    2q11.2; chr2:97713576-97756364 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Zap70 mouse models; 2 with human ZAP70 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    62 phenotypes from 19 alleles in 23 genetic backgrounds
    19 phenotypes from multigenic genotypes
    97 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mutant mice show T cell defects. Null mutants lack alpha-beta T cells in the thymus and have fewer T cells in dendritic and intestinal epithelium. Spontaneous and knock-in missense mutations affect T cell receptor signaling, one of the former resulting in severe chronic arthritis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    66
  • GO References
    27
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    741
  • Tissues
    27
  • cDNA Data
    24
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 22637 NCBI Gene Model | MGI Sequence Detail 20988 C57BL/6J ±  kb
    transcript NM_001289766 RefSeq | MGI Sequence Detail 2250 ZRU/MplStud  
    polypeptide P43404 UniProt | EBI | MGI Sequence Detail 618 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000003064 tyrosine-protein kinase ZAP-70
      (term hierarchy)
    • EC
      2.7.10.2
    • InterPro Domains
      IPR050198 Non-receptor tyrosine kinases involved in cell signaling
      IPR017441 Protein kinase, ATP binding site
      IPR000719 Protein kinase domain
      IPR011009 Protein kinase-like domain superfamily
      IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
      IPR000980 SH2 domain
      IPR036860 SH2 domain superfamily
      IPR035838 SYK/ZAP-70, N-terminal SH2 domain
      IPR051184 Tyrosine-phosphorylated adapter molecule
      IPR008266 Tyrosine-protein kinase, active site
      IPR020635 Tyrosine-protein kinase, catalytic domain
      IPR012234 Tyrosine-protein kinase, non-receptor SYK/ZAP-70
      IPR023420 Tyrosine-protein kinase SYK/ZAP-70, inter-SH2 domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 27
      Genomic 1
      cDNA 25
      Primer pair 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-16398, MGI:2138217, MGI:3584397, MGI:3584398
    References
    more
    • Summaries
      All 183
      Developmental Gene Expression 3
      Diseases 1
      Gene Ontology 27
      Phenotypes 97
    • Earliest
      J:18037 Chan AC, et al., Differential expression of ZAP-70 and Syk protein tyrosine kinases, and the role of this family of protein tyrosine kinases in TCR signaling. J Immunol. 1994 May 15;152(10):4758-66
    • Latest
      J:350708 Eggert J, et al., Cbl-b mitigates the responsiveness of naive CD8(+) T cells that experience extensive tonic T cell receptor signaling. Sci Signal. 2024 Feb 6;17(822):eadh0439
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory