Mark2 MGI Mouse Gene Detail - MGI:99638 - MAP/microtubule affinity regulating kinase 2

Symbol

Mark2
Name

MAP/microtubule affinity regulating kinase 2
Synonyms

Emk, Par-1

Feature Type

protein coding gene
IDs

MGI:99638
NCBI Gene: 13728
Alliance

gene page
Transcription Start Sites

16 TSS

Sequence Map

Chr19:7252761-7319222 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 5.32 cM, cytoband B
Mapping Data

6 experiments

SNPs within 2kb

1294 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_99638	protein coding gene	Chr19:7252761-7319225 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0024789	protein coding gene	Chr19:4398006-4469525 (-)
A/J	MGP_AJ_G0024756	protein coding gene	Chr19:4049020-4115841 (-)
AKR/J	MGP_AKRJ_G0024729	protein coding gene	Chr19:4179318-4246908 (-)
BALB/cJ	MGP_BALBcJ_G0024756	protein coding gene	Chr19:4162883-4230561 (-)
C3H/HeJ	MGP_C3HHeJ_G0024523	protein coding gene	Chr19:4310358-4377028 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0025202	protein coding gene	Chr19:4486754-4558259 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022636	protein coding gene	Chr19:3954224-4021145 (-)
CAST/EiJ	MGP_CASTEiJ_G0023996	protein coding gene	Chr19:4213738-4279932 (-)
CBA/J	MGP_CBAJ_G0024496	protein coding gene	Chr19:4564196-4634553 (-)
DBA/2J	MGP_DBA2J_G0024623	protein coding gene	Chr19:4014703-4081467 (-)
FVB/NJ	MGP_FVBNJ_G0024588	protein coding gene	Chr19:4052188-4123021 (-)
LP/J	MGP_LPJ_G0024709	protein coding gene	Chr19:4249260-4318526 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024618	protein coding gene	Chr19:4454287-4528438 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025250	protein coding gene	Chr19:4323891-4395301 (-)
PWK/PhJ	MGP_PWKPhJ_G0023742	protein coding gene	Chr19:4064539-4133121 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0023546	protein coding gene	Chr19:4129159-4202438 (-)
WSB/EiJ	MGP_WSBEiJ_G0024058	protein coding gene	Chr19:4225797-4295706 (-)

Human Ortholog

MARK2, microtubule affinity regulating kinase 2

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MARK2, microtubule affinity regulating kinase 2
Synonyms

EMK-1, EMK1, PAR-1, Par-1b, Par1b
Links

HGNC:3332

NCBI Gene ID: 2011

neXtProt AC: NX_Q7KZI7

UniProt: Q7KZI7
Chr Location

11q13.1; chr11:63838928-63911020 (+) GRCh38

MGI Vertebrate Homology

Mark2 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: MARK2
Gene Tree

Mark2

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Phenotype Summary

67 phenotypes from 2 alleles in 2 genetic backgrounds
3 phenotypes from multigenic genotypes
23 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

117
Endonuclease-mediated

4
Gene trapped

110
Targeted

3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

109 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygotes for targeted null mutations exhibit proportionate dwarfism with smaller pituitaries and reduced growth hormone and prolactin secretion. Mutants develop autoimmunity and fail to breed when mated to each other.

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All GO Annotations

85
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

737
Tissues

19
cDNA Data

127
Literature Summary

8

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase mark2

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All Sequences

171
RefSeq

54
UniProt

21
CCDS

CCDS37903.1, CCDS37904.1, CCDS37905.1, CCDS50378.1

Ensembl

ENSMUSG00000024969 (Evidence)
NCBI Gene

13728

			Length	Strain/Species	Flank
genomic	13728	NCBI Gene Model \| MGI Sequence Detail	66462	C57BL/6J	± kb
transcript	NM_001410248	RefSeq \| MGI Sequence Detail	4459	ZRU/MplStud
polypeptide	Q05512	UniProt \| EBI \| MGI Sequence Detail	776	Not Applicable

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UniProt

21 Sequences
Protein Ontology

PR:000010187 serine/threonine-protein kinase MARK2

(term hierarchy)
EC

2.7.11.1, 2.7.11.26
InterPro Domains

IPR028375 KA1 domain/Ssp2, C-terminal

IPR001772 Kinase associated domain 1 (KA1)

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR008271 Serine/threonine-protein kinase, active site

IPR049508 Serine/threonine-protein kinase MARK 1-4, catalytic domain

IPR015940 Ubiquitin-associated domain
GlyGen

Q05512 4 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (2 sites)

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All nucleic 129

cDNA 127

Primer pair 2

Microarray probesets 7

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MGD-MRK-16423, MGI:2147655

Summaries

All 70

Developmental Gene Expression 8

Gene Ontology 10

Phenotypes 23
Earliest

J:12907 Inglis JD, et al., Emk, a protein kinase with homologs in yeast maps to mouse chromosome 19. Mamm Genome. 1993;4(7):401-3
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Mark2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr157968	Chr19:7319213-7319228 (-)	1 bp
Tssr157967	Chr19:7319157-7319194 (-)	46 bp
Tssr157966	Chr19:7318936-7319012 (-)	248 bp
Tssr157965	Chr19:7311571-7311594 (-)	7,639 bp
Tssr157964	Chr19:7310505-7310508 (-)	8,715 bp
Tssr157963	Chr19:7300449-7300452 (-)	18,771 bp
Tssr157962	Chr19:7275004-7275013 (-)	44,213 bp
Tssr157961	Chr19:7274973-7275001 (-)	44,235 bp
Tssr157960	Chr19:7274961-7274968 (-)	44,257 bp
Tssr5427	Chr19:7274949-7274956 (-)	44,269 bp
Tssr157959	Chr19:7272759-7272833 (-)	46,426 bp
Tssr157958	Chr19:7272442-7272475 (-)	46,763 bp
Tssr157957	Chr19:7265877-7265881 (-)	53,343 bp
Tssr157956	Chr19:7253301-7253329 (-)	65,907 bp
Tssr157955	Chr19:7253224-7253254 (-)	65,983 bp
Tssr157954	Chr19:7253210-7253223 (-)	66,005 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24