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Adcy5 Gene Detail
Summary
  • Symbol
    Adcy5
  • Name
    adenylate cyclase 5
  • Synonyms
    AC5
  • Feature Type
    protein coding gene
  • IDs
    MGI:99673
    NCBI Gene: 224129
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:34975247-35126108 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 24.71 cM, cytoband B-5
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3853 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99673
 protein coding gene Chr16:34974933-35126108 (+)
129S1/SvImJ MGP_129S1SvImJ_G0022766
 protein coding gene Chr16:33449061-33610976 (+)
A/J MGP_AJ_G0022731
 protein coding gene Chr16:31830131-31983739 (+)
AKR/J MGP_AKRJ_G0022704
 protein coding gene Chr16:32945475-33101834 (+)
BALB/cJ MGP_BALBcJ_G0022733
 protein coding gene Chr16:31960486-32114860 (+)
C3H/HeJ MGP_C3HHeJ_G0022498
 protein coding gene Chr16:33087523-33250186 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023182
 protein coding gene Chr16:34166246-34337339 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020700
 protein coding gene Chr16:32198662-32350459 (+)
CAST/EiJ MGP_CASTEiJ_G0022026
 protein coding gene Chr16:33290307-33458527 (+)
CBA/J MGP_CBAJ_G0022468
 protein coding gene Chr16:35569877-35744064 (+)
DBA/2J MGP_DBA2J_G0022601
 protein coding gene Chr16:31662955-31814512 (+)
FVB/NJ MGP_FVBNJ_G0022576
 protein coding gene Chr16:31655559-31814045 (+)
LP/J MGP_LPJ_G0022668
 protein coding gene Chr16:33175097-33336951 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022595
 protein coding gene Chr16:34862635-35022822 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023194
 protein coding gene Chr16:32982743-33152672 (+)
PWK/PhJ MGP_PWKPhJ_G0021767
 protein coding gene Chr16:32056400-32246406 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021598
 protein coding gene Chr16:32800058-32954318 (+)
WSB/EiJ MGP_WSBEiJ_G0022070
 protein coding gene Chr16:32931010-33090901 (+)



Homology
more
  • Human Ortholog
    ADCY5, adenylate cyclase 5
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ADCY5, adenylate cyclase 5
  • Synonyms
    AC5, DSKOD, FDFM
  • Links
    NCBI Gene ID: 111
    neXtProt AC: NX_O95622
    UniProt: O95622

  • Chr Location
    3q21.1; chr3:123282296-123449090 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Adcy5 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    52 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Targeted inactivation of this gene has been shown to result in motor dysfunction.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    43
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1063
  • Tissues
    222
  • cDNA Data
    40
  • Literature Summary
    10
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022840 Ensembl Gene Model | MGI Sequence Detail 150862 C57BL/6J ±  kb
transcript ENSMUST00000114913 Ensembl | MGI Sequence Detail 7008 Not Applicable  
polypeptide ENSMUSP00000110563 Ensembl | MGI Sequence Detail 1262 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 49
    cDNA 43
    Primer pair 2
    Other 4

    Microarray probesets 8
Other
Accession IDs
less
MGD-MRK-16458, MGI:2146623
References
more
  • Summaries
    All 95
    Developmental Gene Expression 10
    Diseases 1
    Gene Ontology 13
    Phenotypes 52
  • Earliest
    J:46603 Premont RT, et al., Two members of a widely expressed subfamily of hormone-stimulated adenylyl cyclases. Proc Natl Acad Sci U S A. 1992 Oct 15;89(20):9809-13
  • Latest
    J:306469 Dommel S, et al., Effects of Whole-Body Adenylyl Cyclase 5 (Adcy5) Deficiency on Systemic Insulin Sensitivity and Adipose Tissue. Int J Mol Sci. 2021 Apr 21;22(9)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory