Adcy1 MGI Mouse Gene Detail - MGI:99677

Symbol

Adcy1
Name

adenylate cyclase 1
Synonyms

AC1, D11Bwg1392e, I-AC

Feature Type

protein coding gene
IDs

MGI:99677
NCBI Gene: 432530
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr11:7013489-7128506 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 4.72 cM, cytoband A2
Mapping Data

7 experiments

SNPs within 2kb

3628 from dbSNP Build 142
Strain Annotations

18
PCR

2
RFLP

2

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_99677	protein coding gene	Chr11:7013433-7128506 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018032	protein coding gene	Chr11:4256292-4379151 (+)
A/J	MGP_AJ_G0018005	protein coding gene	Chr11:4043034-4158501 (+)
AKR/J	MGP_AKRJ_G0017969	protein coding gene	Chr11:4235071-4351507 (+)
BALB/cJ	MGP_BALBcJ_G0017973	protein coding gene	Chr11:4042500-4157941 (+)
C3H/HeJ	MGP_C3HHeJ_G0017786	protein coding gene	Chr11:4140559-4257021 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018425	protein coding gene	Chr11:4343513-4462139 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016083	protein coding gene	Chr11:3913288-4030183 (+)
CAST/EiJ	MGP_CASTEiJ_G0017348	protein coding gene	Chr11:4126280-4248319 (+)
CBA/J	MGP_CBAJ_G0017761	protein coding gene	Chr11:4841675-4958994 (+)
DBA/2J	MGP_DBA2J_G0017871	protein coding gene	Chr11:3960345-4075388 (+)
FVB/NJ	MGP_FVBNJ_G0017863	protein coding gene	Chr11:3997049-4113200 (+)
LP/J	MGP_LPJ_G0017942	protein coding gene	Chr11:4316232-4431979 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017889	protein coding gene	Chr11:4378615-4491609 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018465	protein coding gene	Chr11:4286301-4405719 (+)
PWK/PhJ	MGP_PWKPhJ_G0017128	protein coding gene	Chr11:3997413-4114594 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016925	protein coding gene	Chr11:4208419-4331057 (+)
WSB/EiJ	MGP_WSBEiJ_G0017402	protein coding gene	Chr11:4090179-4209715 (+)

Human Ortholog

ADCY1, adenylate cyclase 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ADCY1, adenylate cyclase 1
Synonyms

AC1, DFNB44
Links

HGNC:232

NCBI Gene ID: 107

neXtProt AC: NX_Q08828

UniProt: Q08828
Chr Location

7p12.3; chr7:45574140-45723116 (+) GRCh38

MGI Vertebrate Homology

Adcy1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: ADCY1
Protein SuperFamily

Ade_cyc
Gene Tree

Adcy1

Diseases

1 with human ADCY1 associations

				Human Disease	Mouse Models
				autosomal recessive nonsyndromic deafness 44 IDs autosomal recessive nonsyndromic deafness 44 DOID:0110501 ICD10CM:H90.3 OMIM:610154

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

25 phenotypes from 5 alleles in 9 genetic backgrounds
5 phenotypes from multigenic genotypes
87 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Endonuclease-mediated

2
Spontaneous

1
Targeted

8
Transgenic

1
Genomic Mutations

1 involving Adcy1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

73 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for an insertional or null mutation fail to develop normal patterned distribution of neurons in the brain and display behavioral and learning abnormalities.

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All GO Annotations

45
GO References

18

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1476
Tissues

284
cDNA Data

13
Literature Summary

14

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase adcy1

ZFIN adcy1a, adcy1b

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All Sequences

42
RefSeq

2
UniProt

2
CCDS

CCDS24426.1

Ensembl

ENSMUSG00000020431 (Evidence)
NCBI Gene

432530

			Length	Strain/Species	Flank
genomic	ENSMUSG00000020431	Ensembl Gene Model \| MGI Sequence Detail	115018	C57BL/6J	± kb
transcript	ENSMUST00000020706	Ensembl \| MGI Sequence Detail	12259	Not Applicable
polypeptide	ENSMUSP00000020706	Ensembl \| MGI Sequence Detail	1118	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000003751 adenylate cyclase type 1

(term hierarchy)
EC

4.6.1.1
InterPro Domains

IPR030672 Adenylate cyclase

IPR032628 Adenylate cyclase, N-terminal

IPR001054 Adenylyl cyclase class-3/4/guanylyl cyclase

IPR018297 Adenylyl cyclase class-4/guanylyl cyclase, conserved site

IPR029787 Nucleotide cyclase
GlyGen

O88444 1 site

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All nucleic 25

Genomic 5

cDNA 15

Primer pair 4

Other 1

Microarray probesets 5

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MGD-MRK-16462, MGD-MRK-33713, MGD-MRK-34052, MGI:106029, MGI:106360

Summaries

All 138

Developmental Gene Expression 14

Gene Ontology 18

Phenotypes 87
Earliest

J:22287 Wu ZL, et al., Altered behavior and long-term potentiation in type I adenylyl cyclase mutant mice. Proc Natl Acad Sci U S A. 1995 Jan 3;92(1):220-4
Latest

J:350168 Welsh SJ, et al., Transcriptional Heterogeneity Overcomes Super-Enhancer Disrupting Drug Combinations in Multiple Myeloma. Blood Cancer Discov. 2024 Jan 8;5(1):34-55

TSS for Adcy1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr100287	Chr11:7013329-7013338 (+)	-155 bp
Tssr100288	Chr11:7013401-7013404 (+)	-86 bp
Tssr100289	Chr11:7013423-7013496 (+)	-29 bp
Tssr100290	Chr11:7013732-7013758 (+)	256 bp
Tssr100291	Chr11:7069742-7069745 (+)	56,255 bp
Tssr100292	Chr11:7095057-7095088 (+)	81,584 bp
Tssr100293	Chr11:7110050-7110063 (+)	96,568 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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