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Pola2 Gene Detail
Summary
  • Symbol
    Pola2
  • Name
    polymerase (DNA directed), alpha 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:99690
    NCBI Gene: 18969
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:5990570-6014230 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 4.34 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    766 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99690
 protein coding gene Chr19:5990570-6014266 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024734
 protein coding gene Chr19:2956507-2983366 (-)
A/J MGP_AJ_G0024700
 protein coding gene Chr19:2790730-2815984 (-)
AKR/J MGP_AKRJ_G0024673
 protein coding gene Chr19:2874624-2898091 (-)
BALB/cJ MGP_BALBcJ_G0024700
 protein coding gene Chr19:2783123-2808197 (-)
C3H/HeJ MGP_C3HHeJ_G0024468
 protein coding gene Chr19:2891600-2915984 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025147
 protein coding gene Chr19:3018052-3042408 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022577
 protein coding gene Chr19:2692728-2745207 (-)
CAST/EiJ MGP_CASTEiJ_G0023940
 protein coding gene Chr19:2898650-2922340 (-)
CBA/J MGP_CBAJ_G0024440
 protein coding gene Chr19:3159168-3184411 (-)
DBA/2J MGP_DBA2J_G0024567
 protein coding gene Chr19:2781327-2805218 (-)
FVB/NJ MGP_FVBNJ_G0024533
 protein coding gene Chr19:2785421-2809068 (-)
LP/J MGP_LPJ_G0024653
 protein coding gene Chr19:2915638-2955422 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024563
 protein coding gene Chr19:2978013-3001624 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025195
 protein coding gene Chr19:2888318-2914681 (-)
PWK/PhJ MGP_PWKPhJ_G0023686
 protein coding gene Chr19:2804436-2828412 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023491
 protein coding gene Chr19:2873214-2896896 (-)
WSB/EiJ MGP_WSBEiJ_G0024002
 protein coding gene Chr19:2907246-2932631 (-)



Homology
more
  • Human Ortholog
    POLA2, DNA polymerase alpha 2, accessory subunit
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    POLA2, DNA polymerase alpha 2, accessory subunit
  • Links
    NCBI Gene ID: 23649
    neXtProt AC: NX_Q14181
    UniProt: Q14181

  • Chr Location
    11q13.1; chr11:65261913-65305985 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    21
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1043
  • Tissues
    124
  • cDNA Data
    100
  • Literature Summary
    5
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024833 Ensembl Gene Model | MGI Sequence Detail 23661 C57BL/6J ±  kb
transcript ENSMUST00000025752 Ensembl | MGI Sequence Detail 2421 Not Applicable  
polypeptide ENSMUSP00000025752 Ensembl | MGI Sequence Detail 600 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    10 Sequences
  • Protein Ontology
    PR:000012961 DNA polymerase alpha subunit B
    (term hierarchy)
  • InterPro Domains
    IPR007185 DNA polymerase alpha/delta/epsilon, subunit B
    IPR016722 DNA polymerase alpha, subunit B
    IPR013627 DNA polymerase alpha, subunit B, N-terminal
    IPR043034 DNA polymerase alpha, subunit B, N-terminal domain superfamily
Molecular
Reagents
less
  • All nucleic 104
    cDNA 102
    Primer pair 2

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-16475, MGI:2147578
References
more
  • Summaries
    All 46
    Developmental Gene Expression 5
    Gene Ontology 8
    Phenotypes 13
  • Earliest
    J:4544 Miyazawa H, et al., Molecular cloning of the cDNAs for the four subunits of mouse DNA polymerase alpha-primase complex and their gene expression during cell proliferation and the cell cycle. J Biol Chem. 1993 Apr 15;268(11):8111-22
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory