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Cttn Gene Detail
Summary
  • Symbol
    Cttn
  • Name
    cortactin
  • Synonyms
    1110020L01Rik, Ems1
  • Feature Type
    protein coding gene
  • IDs
    MGI:99695
    NCBI Gene: 13043
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:143989468-144024743 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 88.84 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    638 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99695
 protein coding gene Chr7:143989468-144024746 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033287
 protein coding gene Chr7:149790688-149831024 (-)
A/J MGP_AJ_G0033270
 protein coding gene Chr7:145441571-145476991 (-)
AKR/J MGP_AKRJ_G0033201
 protein coding gene Chr7:149539430-149576719 (-)
BALB/cJ MGP_BALBcJ_G0033270
 protein coding gene Chr7:145224057-145260065 (-)
C3H/HeJ MGP_C3HHeJ_G0032984
 protein coding gene Chr7:149303361-149338889 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033780
 protein coding gene Chr7:155206062-155243579 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030753
 protein coding gene Chr7:146594323-146627668 (-)
CAST/EiJ MGP_CASTEiJ_G0032307
 protein coding gene Chr7:141603704-141640548 (-)
CBA/J MGP_CBAJ_G0032957
 protein coding gene Chr7:160494987-160533570 (-)
DBA/2J MGP_DBA2J_G0033111
 protein coding gene Chr7:143419292-143457875 (-)
FVB/NJ MGP_FVBNJ_G0033059
 protein coding gene Chr7:143356772-143393686 (-)
LP/J MGP_LPJ_G0033203
 protein coding gene Chr7:151321488-151359153 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033093
 protein coding gene Chr7:161037678-161076799 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033798
 protein coding gene Chr7:148499096-148541211 (-)
PWK/PhJ MGP_PWKPhJ_G0032017
 protein coding gene Chr7:136724568-136761829 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031861
 protein coding gene Chr7:135286073-135326102 (-)
WSB/EiJ MGP_WSBEiJ_G0032420
 protein coding gene Chr7:149494719-149532383 (-)



Homology
more
  • Human Ortholog
    CTTN, cortactin
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CTTN, cortactin
  • Synonyms
    EMS1
  • Links
    NCBI Gene ID: 2017
    neXtProt AC: NX_Q14247
    UniProt: Q14247

  • Chr Location
    11q13.3; chr11:70398404-70436584 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    21 phenotypes from 5 alleles in 7 genetic backgrounds
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for one knock-out allele exhibit abnormal early zygote development and die prior to the 2-cell stage. Mice homozygous for a different knock-out allele exhibit increased permeability in vascular and lung endothelial cells and impaired neutrophil extravasation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    101
  • GO References
    33
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    894
  • Tissues
    95
  • cDNA Data
    25
  • Literature Summary
    23
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 13043 NCBI Gene Model | MGI Sequence Detail 35276 C57BL/6J ±  kb
    transcript NM_007803 RefSeq | MGI Sequence Detail 3032 C57BL/6  
    polypeptide Q60598 UniProt | EBI | MGI Sequence Detail 546 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 27
      cDNA 25
      Primer pair 1
      Other 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-16480, MGI:1915873
    References
    more
    • Summaries
      All 119
      Developmental Gene Expression 23
      Gene Ontology 33
      Phenotypes 18
    • Earliest
      J:19932 Zhan X, et al., Murine cortactin is phosphorylated in response to fibroblast growth factor-1 on tyrosine residues late in the G1 phase of the BALB/c 3T3 cell cycle. J Biol Chem. 1993 Nov 15;268(32):24427-31
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory