Cdc25b MGI Mouse Gene Detail - MGI:99701

Symbol

Cdc25b
Name

cell division cycle 25B

Feature Type

protein coding gene
IDs

MGI:99701
NCBI Gene: 12531
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr2:131028869-131040417 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 63.29 cM
Mapping Data

5 experiments

SNPs within 2kb

308 from dbSNP Build 142
Strain Annotations

18
RFLP

2

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_99701	protein coding gene	Chr2:131028356-131040431 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0026526	protein coding gene	Chr2:134699609-134713042 (+)
A/J	MGP_AJ_G0026490	protein coding gene	Chr2:129233436-129244941 (+)
AKR/J	MGP_AKRJ_G0026465	protein coding gene	Chr2:132966722-132978259 (+)
BALB/cJ	MGP_BALBcJ_G0026502	protein coding gene	Chr2:129620023-129631561 (+)
C3H/HeJ	MGP_C3HHeJ_G0026245	protein coding gene	Chr2:133400999-133412537 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0026947	protein coding gene	Chr2:138836227-138847758 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024324	protein coding gene	Chr2:123978591-123990165 (+)
CAST/EiJ	MGP_CASTEiJ_G0025706	protein coding gene	Chr2:133683721-133695322 (+)
CBA/J	MGP_CBAJ_G0026225	protein coding gene	Chr2:144008250-144019792 (+)
DBA/2J	MGP_DBA2J_G0026359	protein coding gene	Chr2:128623705-128635500 (+)
FVB/NJ	MGP_FVBNJ_G0026323	protein coding gene	Chr2:127253379-127264915 (+)
LP/J	MGP_LPJ_G0026464	protein coding gene	Chr2:134929084-134940605 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026343	protein coding gene	Chr2:147821191-147842683 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027002	protein coding gene	Chr2:132916364-132935571 (+)
PWK/PhJ	MGP_PWKPhJ_G0025442	protein coding gene	Chr2:128193754-128205414 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025244	protein coding gene	Chr2:132073975-132087220 (+)
WSB/EiJ	MGP_WSBEiJ_G0025780	protein coding gene	Chr2:133846116-133857694 (+)

Human Ortholog

CDC25B, cell division cycle 25B

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CDC25B, cell division cycle 25B
Links

HGNC:1726

NCBI Gene ID: 994

neXtProt AC: NX_P30305

UniProt: P30305
Chr Location

20p13; chr20:3786772-3806121 (+) GRCh38

MGI Vertebrate Homology

Cdc25b stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CDC25B
Gene Tree

Cdc25b

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Phenotype Summary

6 phenotypes from 2 alleles in 2 genetic backgrounds
14 phenotypes from multigenic genotypes
4 images
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

1
Gene trapped

1
Radiation induced

1
Targeted

4
Genomic Mutations

2 involving Cdc25b
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

30 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

The resumption of meiosis during oocyte maturation is blocked in homozygous mutant female mice, resulting in female infertility. Male mice do not show an overt reproductive phenotype.

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All GO Annotations

31
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

771
Tissues

34
cDNA Data

60
Literature Summary

28

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cdc25b

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All Sequences

55
RefSeq

5
UniProt

4
CCDS

CCDS16758.1, CCDS50717.1

Ensembl

ENSMUSG00000027330 (Evidence)
NCBI Gene

12531

			Length	Strain/Species	Flank
genomic	ENSMUSG00000027330	Ensembl Gene Model \| MGI Sequence Detail	11549	C57BL/6J	± kb
transcript	ENSMUST00000028804	Ensembl \| MGI Sequence Detail	3089	Not Applicable
polypeptide	ENSMUSP00000028804	Ensembl \| MGI Sequence Detail	576	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000005192 M-phase inducer phosphatase 2

(term hierarchy)
EC

3.1.3.48
InterPro Domains

IPR000751 M-phase inducer phosphatase

IPR001763 Rhodanese-like domain

IPR036873 Rhodanese-like domain superfamily

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All nucleic 69

Genomic 4

cDNA 61

Primer pair 4

Microarray probesets 4

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MGD-MRK-16486, MGI:2139016

Summaries

All 84

Developmental Gene Expression 28

Gene Ontology 10

Phenotypes 14
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:355487 Han Z, et al., The subcortical maternal complex modulates the cell cycle during early mammalian embryogenesis via 14-3-3. Nat Commun. 2024 Oct 15;15(1):8887

TSS for Cdc25b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr20247	Chr2:131028862-131028891 (+)	8 bp
Tssr20248	Chr2:131028903-131028921 (+)	43 bp
Tssr20249	Chr2:131028924-131028947 (+)	67 bp
Tssr20250	Chr2:131028997-131029038 (+)	149 bp
Tssr20251	Chr2:131030999-131031016 (+)	2,139 bp
Tssr20252	Chr2:131035188-131035196 (+)	6,323 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24