Cmpk2 MGI Mouse Gene Detail - MGI:99830 - cytidine/uridine monophosphate kinase 2

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Cmpk2 Gene Detail

Symbol

Cmpk2
Name

cytidine/uridine monophosphate kinase 2
Synonyms

1200004E04Rik, TDKI, Tyki

Feature Type

protein coding gene
IDs

MGI:99830
NCBI Gene: 22169
Alliance

gene page
Transcription Start Sites

28 TSS

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Sequence Map

Chr12:26519203-26529836 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 9.69 cM
Mapping Data

2 experiments

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SNPs within 2kb

380 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates	Select Strains
C57BL/6J	MGI_C57BL6J_99830	protein coding gene	Chr12:26519121-26529836 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019638	protein coding gene	Chr12:24203329-24216339 (+)
A/J	MGP_AJ_G0019605	protein coding gene	Chr12:23572907-23584234 (+)
AKR/J	MGP_AKRJ_G0019576	protein coding gene	Chr12:24330637-24341248 (+)
BALB/cJ	MGP_BALBcJ_G0019582	protein coding gene	Chr12:23807700-23818543 (+)
C3H/HeJ	MGP_C3HHeJ_G0019386	protein coding gene	Chr12:24222998-24236084 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020029	protein coding gene	Chr12:24979214-24994536 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017654	protein coding gene	Chr12:23004196-23014809 (+)
CAST/EiJ	MGP_CASTEiJ_G0018941	protein coding gene	Chr12:19201177-19212724 (+)
CBA/J	MGP_CBAJ_G0019357	protein coding gene	Chr12:25778305-25791736 (+)
DBA/2J	MGP_DBA2J_G0019471	protein coding gene	Chr12:23387881-23398492 (+)
FVB/NJ	MGP_FVBNJ_G0019462	protein coding gene	Chr12:23259688-23270371 (+)
LP/J	MGP_LPJ_G0019541	protein coding gene	Chr12:24271205-24282592 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019497	protein coding gene	Chr12:25554717-25565443 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020069	protein coding gene	Chr12:23885256-23895915 (+)
PWK/PhJ	MGP_PWKPhJ_G0018708	protein coding gene	Chr12:18140850-18167426 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018496	protein coding gene	Chr12:18387821-18414691 (+)
WSB/EiJ	MGP_WSBEiJ_G0018992	protein coding gene	Chr12:24077685-24088292 (+)

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Human Ortholog

CMPK2, cytidine/uridine monophosphate kinase 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CMPK2, cytidine/uridine monophosphate kinase 2
Synonyms

NDK, TMPK2, TYKi, UMP-CMPK2
Links

HGNC:27015

NCBI Gene ID: 129607

neXtProt AC: NX_Q5EBM0

UniProt: Q5EBM0
Chr Location

2p25.2; chr2:6840553-6866635 (-) GRCh38

MGI Vertebrate Homology

Cmpk2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CMPK2
Protein SuperFamily

dTMP_TKRP1
Gene Tree

Cmpk2

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Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
10 phenotype references

Phenotype Overview

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Endonuclease-mediated

3
Targeted

5
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

34 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

32
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

878
Tissues

120
cDNA Data

50
Literature Summary

3

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cmpk2

ZFIN cmpk2

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All Sequences

42
RefSeq

4
UniProt

1
CCDS

CCDS49039.1

Ensembl

ENSMUSG00000020638 (Evidence)
NCBI Gene

22169

Representative Sequences				Length	Strain/Species	Flank
	genomic	ENSMUSG00000020638	Ensembl Gene Model \| MGI Sequence Detail	10634	C57BL/6J	± kb
	transcript	ENSMUST00000020969	Ensembl \| MGI Sequence Detail	3200	Not Applicable
	polypeptide	ENSMUSP00000020969	Ensembl \| MGI Sequence Detail	447	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000005625 UMP-CMP kinase 2, mitochondrial

(term hierarchy)
EC

2.7.4.14, 2.7.4.6
InterPro Domains

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR039430 Thymidylate kinase-like domain

IPR014505 UMP-CMP kinase 2, mitochondrial

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All nucleic 51

cDNA 51

Microarray probesets 4

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MGD-MRK-16617, MGI:1918964

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Summaries

All 44

Developmental Gene Expression 3

Gene Ontology 10

Phenotypes 10
Earliest

J:21542 Lee CG, et al., Localization of a novel, LPS-inducible member of the thymidylate kinase family to mouse chromosome 12. Mamm Genome. 1994 Nov;5(11):742-3
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Cmpk2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr113013	Chr12:26519372-26519396 (+)	181 bp
Tssr113014	Chr12:26519905-26519980 (+)	740 bp
Tssr113015	Chr12:26520348-26520359 (+)	1,151 bp
Tssr113016	Chr12:26520426-26520455 (+)	1,238 bp
Tssr113017	Chr12:26520506-26520510 (+)	1,305 bp
Tssr113018	Chr12:26522618-26522634 (+)	3,423 bp
Tssr113019	Chr12:26523402-26523414 (+)	4,205 bp
Tssr113020	Chr12:26524031-26524066 (+)	4,846 bp
Tssr113021	Chr12:26526207-26526218 (+)	7,010 bp
Tssr113022	Chr12:26527050-26527063 (+)	7,854 bp
Tssr113023	Chr12:26528010-26528020 (+)	8,812 bp
Tssr113024	Chr12:26528096-26528110 (+)	8,900 bp
Tssr113025	Chr12:26528115-26528129 (+)	8,919 bp
Tssr113026	Chr12:26528140-26528158 (+)	8,946 bp
Tssr113027	Chr12:26528160-26528188 (+)	8,971 bp
Tssr113028	Chr12:26528217-26528230 (+)	9,021 bp
Tssr113029	Chr12:26528253-26528276 (+)	9,062 bp
Tssr113030	Chr12:26528338-26528366 (+)	9,149 bp
Tssr113031	Chr12:26528389-26528401 (+)	9,192 bp
Tssr113032	Chr12:26528469-26528480 (+)	9,272 bp
Tssr113033	Chr12:26528852-26528871 (+)	9,659 bp
Tssr113034	Chr12:26529033-26529044 (+)	9,836 bp
Tssr113035	Chr12:26529107-26529120 (+)	9,911 bp
Tssr113036	Chr12:26529176-26529190 (+)	9,980 bp
Tssr113037	Chr12:26529197-26529213 (+)	10,002 bp
Tssr113038	Chr12:26529220-26529233 (+)	10,024 bp
Tssr113039	Chr12:26529238-26529259 (+)	10,046 bp
Tssr113040	Chr12:26529307-26529318 (+)	10,110 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/05/2024 MGI 6.24