Gdi2 MGI Mouse Gene Detail - MGI:99845 - GDP dissociation inhibitor 2

Symbol

Gdi2
Name

GDP dissociation inhibitor 2
Synonyms

Gdi3, GDI-B, GDIB, GDI beta

Feature Type

protein coding gene
IDs

MGI:99845
NCBI Gene: 14569
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr13:3588075-3616261 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 1.98 cM, cytoband A1
Mapping Data

3 experiments

SNPs within 2kb

591 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_99845	protein coding gene	Chr13:3588063-3617871 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020193	protein coding gene	Chr13:6564-37100 (+)
A/J	MGP_AJ_G0020149	protein coding gene	Chr13:129619-157617 (+)
AKR/J	MGP_AKRJ_G0020124	protein coding gene	Chr13:111734-139272 (+)
BALB/cJ	MGP_BALBcJ_G0020132	protein coding gene	Chr13:100278-129982 (+)
C3H/HeJ	MGP_C3HHeJ_G0019936	protein coding gene	Chr13:174946-208956 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020579	protein coding gene	Chr13:78422-108644 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018191	protein coding gene	Chr13:78624-102369 (+)
CAST/EiJ	MGP_CASTEiJ_G0019476	protein coding gene	Chr13:19929-49362 (+)
CBA/J	MGP_CBAJ_G0019903	protein coding gene	Chr13:109869-138753 (+)
DBA/2J	MGP_DBA2J_G0020020	protein coding gene	Chr13:24947-53528 (+)
FVB/NJ	MGP_FVBNJ_G0020005	protein coding gene	Chr13:21108-47712 (+)
LP/J	MGP_LPJ_G0020094	protein coding gene	Chr13:77072-114036 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020041	protein coding gene	Chr13:111450-141552 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020608	protein coding gene	Chr13:89290-122129 (+)
PWK/PhJ	MGP_PWKPhJ_G0019238	protein coding gene	Chr13:86283-115374 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0019043	protein coding gene	Chr13:137981-168310 (+)
WSB/EiJ	MGP_WSBEiJ_G0019534	protein coding gene	Chr13:14460-43621 (+)

Human Ortholog

GDI2, GDP dissociation inhibitor 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GDI2, GDP dissociation inhibitor 2
Synonyms

HEL-S-46e, RABGDIB
Links

HGNC:4227

NCBI Gene ID: 2665

neXtProt AC: NX_P50395

UniProt: P50395
Chr Location

10p15.1; chr10:5765223-5842132 (-) GRCh38

MGI Vertebrate Homology

Gdi2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: GDI2
Gene Tree

Gdi2

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Phenotype Summary

10 phenotypes from 2 alleles in 2 genetic backgrounds
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

15
Endonuclease-mediated

2
Gene trapped

10
Targeted

3
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

36 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Knock-out results in embryonic lethality between E10.5 to E14.5, with extensive cell death and cell loss is embryos and increased apoptosis in E12.5 livers.

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All GO Annotations

22
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

833
Tissues

120
cDNA Data

32
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA GDI1

Xenbase gdi2

ZFIN gdi2

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All Sequences

79
RefSeq

2
UniProt

8
CCDS

CCDS36581.1

Ensembl

ENSMUSG00000021218 (Evidence)
NCBI Gene

14569

			Length	Strain/Species	Flank
genomic	14569	NCBI Gene Model \| MGI Sequence Detail	28187	C57BL/6J	± kb
transcript	NM_008112	RefSeq \| MGI Sequence Detail	2681	C57BL/6
polypeptide	Q61598	UniProt \| EBI \| MGI Sequence Detail	445	Not Applicable

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UniProt

8 Sequences
Protein Ontology

PR:000007927 Rab GDP dissociation inhibitor beta

(term hierarchy)
InterPro Domains

IPR036188 FAD/NAD(P)-binding domain superfamily

IPR018203 GDP dissociation inhibitor

IPR000806 Rab GDI protein
GlyGen

Q61598 1 site, 1 O-linked glycan (1 site)

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All nucleic 36

cDNA 33

Primer pair 1

Other 2

Microarray probesets 8

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MGD-MRK-16636, MGD-MRK-33618, MGI:105939

Summaries

All 57

Developmental Gene Expression 6

Gene Ontology 11

Phenotypes 13
Earliest

J:17786 Shisheva A, et al., Cloning, characterization, and expression of a novel GDP dissociation inhibitor isoform from skeletal muscle. Mol Cell Biol. 1994 May;14(5):3459-68
Latest

J:348218 Wang M, et al., GDI2 deletion alleviates neurodegeneration and memory loss in the 5xFAD mice model of Alzheimer's disease. Biochim Biophys Acta Mol Basis Dis. 2024 Feb 19;1870(4):167093

TSS for Gdi2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr118195	Chr13:3588111-3588150 (+)	56 bp
Tssr118196	Chr13:3588439-3588461 (+)	375 bp
Tssr118197	Chr13:3588478-3588484 (+)	406 bp
Tssr118198	Chr13:3588614-3588635 (+)	550 bp
Tssr118199	Chr13:3591810-3591814 (+)	3,737 bp
Tssr118200	Chr13:3598886-3598926 (+)	10,831 bp
Tssr118201	Chr13:3606971-3607018 (+)	18,920 bp
Tssr118202	Chr13:3613901-3613909 (+)	25,830 bp
Tssr118203	Chr13:3614987-3615019 (+)	26,928 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24