Lama1 MGI Mouse Gene Detail - MGI:99892

Symbol

Lama1
Name

laminin, alpha 1
Synonyms

Lama

Feature Type

protein coding gene
IDs

MGI:99892
NCBI Gene: 16772
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr17:68004254-68129642 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 38.80 cM
Mapping Data

12 experiments

SNPs within 2kb

4887 from dbSNP Build 142
Strain Annotations

18
RFLP

4

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_99892	protein coding gene	Chr17:68004129-68129642 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0023992	protein coding gene	Chr17:69983662-70114963 (+)
A/J	MGP_AJ_G0023950	protein coding gene	Chr17:67862344-67990040 (+)
AKR/J	MGP_AKRJ_G0023919	protein coding gene	Chr17:68810989-68941439 (+)
BALB/cJ	MGP_BALBcJ_G0023951	protein coding gene	Chr17:67816246-67943957 (+)
C3H/HeJ	MGP_C3HHeJ_G0023715	protein coding gene	Chr17:69716953-69850872 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0024397	protein coding gene	Chr17:72603292-72733804 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021843	protein coding gene	Chr17:63807775-63937111 (+)
CAST/EiJ	MGP_CASTEiJ_G0023197	protein coding gene	Chr17:70079843-70218779 (+)
CBA/J	MGP_CBAJ_G0023691	protein coding gene	Chr17:75521248-75658863 (+)
DBA/2J	MGP_DBA2J_G0023819	protein coding gene	Chr17:66573994-66699913 (+)
FVB/NJ	MGP_FVBNJ_G0023785	protein coding gene	Chr17:66074579-66200446 (+)
LP/J	MGP_LPJ_G0023901	protein coding gene	Chr17:70706635-70840589 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023813	protein coding gene	Chr17:75525040-75655275 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024441	protein coding gene	Chr17:69263635-69395246 (+)
PWK/PhJ	MGP_PWKPhJ_G0022943	protein coding gene	Chr17:65896495-66039394 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0022754	protein coding gene	Chr17:65999041-66130325 (+)
WSB/EiJ	MGP_WSBEiJ_G0023263	protein coding gene	Chr17:70014396-70146316 (+)

Human Ortholog

LAMA1, laminin subunit alpha 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

LAMA1, laminin subunit alpha 1
Synonyms

LAMA, PTBHS, S-LAM-alpha
Links

HGNC:6481

NCBI Gene ID: 284217

neXtProt AC: NX_P25391

UniProt: P25391
Chr Location

18p11.31

MGI Vertebrate Homology

Lama1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: LAMA1
Gene Tree

Lama1

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Phenotype Summary

51 phenotypes from 9 alleles in 7 genetic backgrounds
1 phenotype from multigenic genotypes
8 images
31 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

18
Chemically induced (ENU)

1
Endonuclease-mediated

1
Gene trapped

4
Targeted

11
Transgenic

1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

186 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice display embryonic lethality before somite formation with impaired formation of Reichert's membrane.

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All GO Annotations

52
GO References

51

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1361
Tissues

351
cDNA Data

23
Literature Summary

183

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase lama1

ZFIN lama1

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All Sequences

49
RefSeq

10
UniProt

1
CCDS

CCDS37681.1

Ensembl

ENSMUSG00000032796 (Evidence)
NCBI Gene

16772

			Length	Strain/Species	Flank
genomic	ENSMUSG00000032796	Ensembl Gene Model \| MGI Sequence Detail	125389	C57BL/6J	± kb
transcript	ENSMUST00000035471	Ensembl \| MGI Sequence Detail	9526	Not Applicable
polypeptide	ENSMUSP00000043957	Ensembl \| MGI Sequence Detail	3083	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000009650 laminin subunit alpha-1

(term hierarchy)
PDB

2JD4, 5MC9, 8DMK
InterPro Domains

IPR013320 Concanavalin A-like lectin/glucanase domain superfamily

IPR000742 EGF-like domain

IPR009254 Laminin alpha, domain I

IPR010307 Laminin domain II

IPR001791 Laminin G domain

IPR000034 Laminin IV

IPR050440 Laminin/Netrin Extracellular Matrix

IPR008211 Laminin, N-terminal

IPR002049 Laminin-type EGF domain
GlyGen

P19137 32 sites, 22 N-linked glycans (29 sites), 1 O-linked glycan (1 site)

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All nucleic 43

cDNA 23

Primer pair 11

Other 9

Microarray probesets 3

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MGD-MRK-11733, MGD-MRK-16687, MGI:2146751

Summaries

All 327

Developmental Gene Expression 183

Gene Ontology 51

Phenotypes 31
Earliest

J:14723 Oberbaumer I, New pUC-derived expression vectors for rapid construction of cDNA libraries. Gene. 1986;49(1):81-91
Latest

J:352032 Wang L, et al., ADAMTS18-fibronectin interaction regulates the morphology of liver sinusoidal endothelial cells. iScience. 2024 Jul 19;27(7):110273

TSS for Lama1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr145613	Chr17:68004222-68004241 (+)	-22 bp
Tssr145614	Chr17:68004248-68004271 (+)	6 bp
Tssr145615	Chr17:68029274-68029290 (+)	25,028 bp
Tssr145616	Chr17:68029348-68029374 (+)	25,107 bp
Tssr145617	Chr17:68035552-68035556 (+)	31,300 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24