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Tnfrsf8 Gene Detail
Summary
  • Symbol
    Tnfrsf8
  • Name
    tumor necrosis factor receptor superfamily, member 8
  • Synonyms
    CD30
  • Feature Type
    protein coding gene
  • IDs
    MGI:99908
    NCBI Gene: 21941
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:144993707-145041734 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 78.17 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1230 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99908
 protein coding gene Chr4:144993702-145041734 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029103
 protein coding gene Chr4:148654776-148704610 (-)
A/J MGP_AJ_G0029070
 protein coding gene Chr4:142383945-142432125 (-)
AKR/J MGP_AKRJ_G0029018
 protein coding gene Chr4:146334418-146386427 (-)
BALB/cJ MGP_BALBcJ_G0029085
 protein coding gene Chr4:143022868-143072757 (-)
C3H/HeJ MGP_C3HHeJ_G0028804
 protein coding gene Chr4:146796013-146843774 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029530
 protein coding gene Chr4:153636507-153684910 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026782
 protein coding gene Chr4:135106522-135153383 (-)
CAST/EiJ MGP_CASTEiJ_G0028220
 protein coding gene Chr4:144857283-144908444 (-)
CBA/J MGP_CBAJ_G0028768
 protein coding gene Chr4:158507467-158561063 (-)
DBA/2J MGP_DBA2J_G0028916
 protein coding gene Chr4:142541440-142589568 (-)
FVB/NJ MGP_FVBNJ_G0028878
 protein coding gene Chr4:141674738-141723839 (-)
LP/J MGP_LPJ_G0029007
 protein coding gene Chr4:148700072-148750591 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028908
 protein coding gene Chr4:162010379-162064226 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029567
 protein coding gene Chr4:146838163-146888053 (-)
PWK/PhJ MGP_PWKPhJ_G0027940
 protein coding gene Chr4:139017370-139067892 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027774
 protein coding gene Chr4:142084180-142138511 (-)
WSB/EiJ MGP_WSBEiJ_G0028299
 protein coding gene Chr4:147086420-147137814 (-)



Homology
more
  • Human Ortholog
    TNFRSF8, TNF receptor superfamily member 8
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TNFRSF8, TNF receptor superfamily member 8
  • Synonyms
    CD30, D1S166E, Ki-1
  • Links
    NCBI Gene ID: 943
    neXtProt AC: NX_P28908
    UniProt: P28908

  • Chr Location
    1p36.22; chr1:12063303-12144207 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 2 genetic backgrounds
    37 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele display an enlarged thymus, impaired activation-induced death of double-positive thymocytes after CD3 cross-linking, and decreased susceptibility to graft versus host disease.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    752
  • Tissues
    45
  • cDNA Data
    12
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028602 Ensembl Gene Model | MGI Sequence Detail 48028 C57BL/6J ±  kb
    transcript ENSMUST00000030339 Ensembl | MGI Sequence Detail 3414 Not Applicable  
    polypeptide ENSMUSP00000030339 Ensembl | MGI Sequence Detail 498 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000001964 tumor necrosis factor receptor superfamily member 8
      (term hierarchy)
    • InterPro Domains
      IPR001368 TNFR/NGFR cysteine-rich region
      IPR052862 Tumor necrosis factor receptor superfamily member 8
      IPR020416 Tumour necrosis factor receptor 8
      IPR034002 Tumour necrosis factor receptor 8, N-terminal
    • GlyGen
      Q60846 3 sites, 1 N-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 15
      cDNA 14
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-16705
    References
    more
    • Summaries
      All 83
      Developmental Gene Expression 1
      Gene Ontology 3
      Phenotypes 37
    • Earliest
      J:3463 Clayton LK, et al., Differential regulation of T-cell receptor processing and surface expression affected by CD3 theta, an alternatively spliced product of the CD3 zeta/eta gene locus. J Biol Chem. 1992 Dec 25;267(36):26023-30
    • Latest
      J:344438 Cui D, et al., CD30 plays a role in T-dependent immune response and T cell proliferation. FASEB J. 2024 Jan;38(1):e23365
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    12/10/2024
    MGI 6.24     		The Jackson Laboratory