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Lamb2 Gene Detail
Summary
  • Symbol
    Lamb2
  • Name
    laminin, beta 2
  • Synonyms
    Lamb-2, Lams, npht
  • Feature Type
    protein coding gene
  • IDs
    MGI:99916
    NCBI Gene: 16779
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:108357080-108367729 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 59.40 cM, cytoband F1
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    235 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99916
 protein coding gene Chr9:108356935-108367729 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035300
 protein coding gene Chr9:110439581-110450340 (+)
A/J MGP_AJ_G0035279
 protein coding gene Chr9:106392774-106403568 (+)
AKR/J MGP_AKRJ_G0035211
 protein coding gene Chr9:109054134-109064928 (+)
BALB/cJ MGP_BALBcJ_G0035273
 protein coding gene Chr9:106089102-106099896 (+)
C3H/HeJ MGP_C3HHeJ_G0034983
 protein coding gene Chr9:109445293-109456087 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035793
 protein coding gene Chr9:113454178-113464972 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032691
 protein coding gene Chr9:103823887-103834642 (+)
CAST/EiJ MGP_CASTEiJ_G0034294
 protein coding gene Chr9:109415670-109426462 (+)
CBA/J MGP_CBAJ_G0034951
 protein coding gene Chr9:117443581-117454426 (+)
DBA/2J MGP_DBA2J_G0035112
 protein coding gene Chr9:105845492-105856286 (+)
FVB/NJ MGP_FVBNJ_G0035060
 protein coding gene Chr9:104612824-104623618 (+)
LP/J MGP_LPJ_G0035188
 protein coding gene Chr9:110633056-110643951 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035099
 protein coding gene Chr9:119028453-119039247 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035814
 protein coding gene Chr9:109339338-109350132 (+)
PWK/PhJ MGP_PWKPhJ_G0034001
 protein coding gene Chr9:106177207-106188028 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033836
 protein coding gene Chr9:109395198-109405996 (+)
WSB/EiJ MGP_WSBEiJ_G0034415
 protein coding gene Chr9:109224913-109235712 (+)



Homology
more
  • Human Ortholog
    LAMB2, laminin subunit beta 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LAMB2, laminin subunit beta 2
  • Synonyms
    LAMS, NPHS5, PIERS
  • Links
    NCBI Gene ID: 3913
    neXtProt AC: NX_P55268
    UniProt: P55268

  • Chr Location
    3p21.31; chr3:49121114-49133118 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with Lamb2 mouse models; 3 with human LAMB2 associations

Human Disease Mouse Models
      
IDs
 View 2 models
      
IDs
 View 1 model
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    38 phenotypes from 3 alleles in 4 genetic backgrounds
    17 phenotypes from multigenic genotypes
    36 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit small size, severe proteinuria due to a defect in glomerular filtration, abnormalities of the retina and skeletal neuromuscular synapses, and lethality by 30 days of age.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    42
  • GO References
    23
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    764
  • Tissues
    48
  • cDNA Data
    133
  • Literature Summary
    39
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16779 NCBI Gene Model | MGI Sequence Detail 10650 C57BL/6J ±  kb
    transcript NM_008483 RefSeq | MGI Sequence Detail 5605 ZRU/MplStud  
    polypeptide Q61292 UniProt | EBI | MGI Sequence Detail 1799 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 145
      Genomic 5
      cDNA 137
      Primer pair 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-11736, MGD-MRK-11747, MGD-MRK-16715, MGI:2143298, MGI:3584415
    References
    more
    • Summaries
      All 130
      Developmental Gene Expression 39
      Diseases 4
      Gene Ontology 23
      Phenotypes 36
    • Earliest
      J:7643 Barlow DP, et al., Sequencing of laminin B chain cDNAs reveals C-terminal regions of coiled-coil alpha-helix. EMBO J. 1984 Oct;3(10):2355-62
    • Latest
      J:353621 Patel VN, et al., Specific 3-O-sulfated heparan sulfate domains regulate salivary gland basement membrane metabolism and epithelial differentiation. Nat Commun. 2024 Aug 31;15(1):7584
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory