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Angpt1 Gene Detail
Summary
  • Symbol
    Angpt1
  • Name
    angiopoietin 1
  • Synonyms
    1110046O21Rik, ang1, Ang-1, Angiopoietin-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:108448
    NCBI Gene: 11600
  • Alliance
    gene page
  • Transcription Start Sites
    16 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:42288119-42540373 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 16.69 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    6864 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_108448
 protein coding gene Chr15:42288063-42540373 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021823
 protein coding gene Chr15:41003228-41264983 (-)
A/J MGP_AJ_G0021783
 protein coding gene Chr15:39426874-39672287 (-)
AKR/J MGP_AKRJ_G0021764
 protein coding gene Chr15:40608171-40861418 (-)
BALB/cJ MGP_BALBcJ_G0021790
 protein coding gene Chr15:39485122-39740529 (-)
C3H/HeJ MGP_C3HHeJ_G0021564
 protein coding gene Chr15:40502238-40760701 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022229
 protein coding gene Chr15:42583589-42852603 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019766
 protein coding gene Chr15:37041980-37275498 (-)
CAST/EiJ MGP_CASTEiJ_G0021081
 protein coding gene Chr15:41033697-41296549 (-)
CBA/J MGP_CBAJ_G0021533
 protein coding gene Chr15:44051564-44337032 (-)
DBA/2J MGP_DBA2J_G0021657
 protein coding gene Chr15:39254921-39503041 (-)
FVB/NJ MGP_FVBNJ_G0021635
 protein coding gene Chr15:38573279-38820370 (-)
LP/J MGP_LPJ_G0021727
 protein coding gene Chr15:40793432-41051609 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021659
 protein coding gene Chr15:47124451-47421920 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022252
 protein coding gene Chr15:40779436-41036855 (-)
PWK/PhJ MGP_PWKPhJ_G0020826
 protein coding gene Chr15:39291242-39540222 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020663
 protein coding gene Chr15:40427251-40693914 (-)
WSB/EiJ MGP_WSBEiJ_G0021136
 protein coding gene Chr15:40677980-40931937 (-)



Homology
more
  • Human Ortholog
    ANGPT1, angiopoietin 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ANGPT1, angiopoietin 1
  • Synonyms
    AGP1, AGPT, AGPT-1, ANG1, HAE5
  • Links
    NCBI Gene ID: 284
    neXtProt AC: NX_Q15389
    UniProt: Q15389

  • Chr Location
    8q23.1; chr8:107249482-107498055 (-)  GRCh38
Human Diseases
more
  • Diseases
    5 with human ANGPT1 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    20 phenotypes from 6 alleles in 4 genetic backgrounds
    26 phenotypes from multigenic genotypes
    3 images
    46 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display embryonic lethality by E12.5 and deficits in vascular development such as a reduction in vascular branching.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    96
  • GO References
    20
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    893
  • Tissues
    84
  • cDNA Data
    30
  • Literature Summary
    117
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022309 Ensembl Gene Model | MGI Sequence Detail 252255 C57BL/6J ±  kb
    transcript ENSMUST00000022921 Ensembl | MGI Sequence Detail 4260 Not Applicable  
    polypeptide ENSMUSP00000022921 Ensembl | MGI Sequence Detail 498 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000004023 angiopoietin-1
      (term hierarchy)
    • InterPro Domains
      IPR002181 Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
      IPR014716 Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1
      IPR020837 Fibrinogen, conserved site
      IPR050373 Fibrinogen C-terminal domain-containing protein
      IPR036056 Fibrinogen-like, C-terminal
    • GlyGen
      O08538 5 sites, 2 N-linked glycans (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 56
      Genomic 1
      cDNA 34
      Primer pair 19
      Other 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-37492, MGI:1916073
    References
    more
    • Summaries
      All 227
      Developmental Gene Expression 117
      Gene Ontology 20
      Phenotypes 46
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:344102 Racedo SE, et al., Dgcr8 functions in the secondary heart field for outflow tract and right ventricle development in mammals. Dev Biol. 2024 Feb;506:72-84
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory