Arg2 MGI Mouse Gene Detail - MGI:1330806

Symbol

Arg2
Name

arginase type II
Synonyms

AII

Feature Type

protein coding gene
IDs

MGI:1330806
NCBI Gene: 11847
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr12:79177562-79203075 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 35.51 cM
Mapping Data

2 experiments

SNPs within 2kb

737 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1330806	protein coding gene	Chr12:79177551-79203075 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019879	protein coding gene	Chr12:79408963-79436642 (+)
A/J	MGP_AJ_G0019837	protein coding gene	Chr12:76554546-76580925 (+)
AKR/J	MGP_AKRJ_G0019812	protein coding gene	Chr12:78628994-78654807 (+)
BALB/cJ	MGP_BALBcJ_G0019816	protein coding gene	Chr12:76808466-76835281 (+)
C3H/HeJ	MGP_C3HHeJ_G0019622	protein coding gene	Chr12:79104773-79130590 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020268	protein coding gene	Chr12:81753487-81781014 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017887	protein coding gene	Chr12:73570714-73597721 (+)
CAST/EiJ	MGP_CASTEiJ_G0019172	protein coding gene	Chr12:73937739-73964482 (+)
CBA/J	MGP_CBAJ_G0019593	protein coding gene	Chr12:84951794-84979921 (+)
DBA/2J	MGP_DBA2J_G0019708	protein coding gene	Chr12:76178828-76204431 (+)
FVB/NJ	MGP_FVBNJ_G0019694	protein coding gene	Chr12:74992371-75017687 (+)
LP/J	MGP_LPJ_G0019780	protein coding gene	Chr12:79342164-79370413 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019733	protein coding gene	Chr12:87987915-88016136 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020303	protein coding gene	Chr12:78142296-78171526 (+)
PWK/PhJ	MGP_PWKPhJ_G0018938	protein coding gene	Chr12:70535746-70563929 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018732	protein coding gene	Chr12:72648540-72674480 (+)
WSB/EiJ	MGP_WSBEiJ_G0019225	protein coding gene	Chr12:78763419-78789895 (+)

Human Ortholog

ARG2, arginase 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ARG2, arginase 2
Links

HGNC:664

NCBI Gene ID: 384

neXtProt AC: NX_P78540

UniProt: P78540
Chr Location

14q24.1; chr14:67619920-67651708 (+) GRCh38

MGI Vertebrate Homology

Arg2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ARG2
Protein SuperFamily

Arginase
Gene Tree

Arg2

Diseases

1 with human ARG2 associations

				Human Disease	Mouse Models
				asthma IDs asthma DOID:2841 DOID:12703 DOID:13829 DOID:13830 DOID:2840 DOID:5783 ICD10CM:J45 ICD9CM:493 ICD9CM:493.9 KEGG:05310 MESH:D001249 NCI:C28397 OMIM:600807 UMLS_CUI:C0004096

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

14 phenotypes from 2 alleles in 2 genetic backgrounds
53 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (other)

1
Endonuclease-mediated

7
Targeted

2
Genomic Mutations

1 involving Arg2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

17 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mutation of this gene results in elevated plasma arginine concentrations.

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All GO Annotations

38
GO References

14

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

927
Tissues

110
cDNA Data

13
Literature Summary

13

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase arg2

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All Sequences

35
RefSeq

2
UniProt

2
CCDS

CCDS26007.1

Ensembl

ENSMUSG00000021125 (Evidence)
NCBI Gene

11847

			Length	Strain/Species	Flank
genomic	11847	NCBI Gene Model \| MGI Sequence Detail	25514	C57BL/6J	± kb
transcript	NM_009705	RefSeq \| MGI Sequence Detail	1417	C57BL/6
polypeptide	O08691	UniProt \| EBI \| MGI Sequence Detail	354	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000004215 arginase-2, mitochondrial

(term hierarchy)
EC

3.5.3.1
InterPro Domains

IPR014033 Arginase

IPR006035 Ureohydrolase

IPR023696 Ureohydrolase domain superfamily

IPR020855 Ureohydrolase, manganese-binding site

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All nucleic 14

cDNA 13

Primer pair 1

Microarray probesets 4

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MGI:2144959

Summaries

All 115

Developmental Gene Expression 13

Gene Ontology 14

Phenotypes 53
Earliest

J:48418 Iyer RK, et al., Cloning and characterization of the mouse and rat type II arginase genes. Mol Genet Metab. 1998 Mar;63(3):168-75
Latest

J:353572 Zhang Y, et al., Hierarchical tricarboxylic acid cycle regulation by hepatocyte arginase 2 links the urea cycle to oxidative metabolism. Cell Metab. 2024 Sep 3;36(9):2069-2085.e8

TSS for Arg2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr3873	Chr12:79177523-79177563 (+)	-19 bp
Tssr114077	Chr12:79177574-79177590 (+)	20 bp
Tssr114078	Chr12:79179138-79179141 (+)	1,578 bp
Tssr114079	Chr12:79182427-79182431 (+)	4,867 bp
Tssr114080	Chr12:79182753-79182781 (+)	5,205 bp
Tssr114081	Chr12:79185098-79185134 (+)	7,554 bp
Tssr114082	Chr12:79186775-79186802 (+)	9,227 bp
Tssr114083	Chr12:79187888-79187910 (+)	10,337 bp
Tssr114084	Chr12:79192621-79192631 (+)	15,064 bp
Tssr114085	Chr12:79196718-79196758 (+)	19,176 bp
Tssr114086	Chr12:79198779-79198799 (+)	21,227 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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