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Nfil3 Gene Detail
Summary
  • Symbol
    Nfil3
  • Name
    nuclear factor, interleukin 3, regulated
  • Synonyms
    E4BP4
  • Feature Type
    protein coding gene
  • IDs
    MGI:109495
    NCBI Gene: 18030
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:53121245-53135109 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 27.68 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    334 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109495
 protein coding gene Chr13:53121245-53136914 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020559
 protein coding gene Chr13:52270064-52283892 (-)
A/J MGP_AJ_G0020513
 protein coding gene Chr13:50394274-50408104 (-)
AKR/J MGP_AKRJ_G0020491
 protein coding gene Chr13:51826360-51839986 (-)
BALB/cJ MGP_BALBcJ_G0020509
 protein coding gene Chr13:50601468-50615257 (-)
C3H/HeJ MGP_C3HHeJ_G0020308
 protein coding gene Chr13:51675920-51689750 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020943
 protein coding gene Chr13:53891020-53904878 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018525
 protein coding gene Chr13:48181024-48195040 (-)
CAST/EiJ MGP_CASTEiJ_G0019822
 protein coding gene Chr13:51683162-51697068 (-)
CBA/J MGP_CBAJ_G0020268
 protein coding gene Chr13:55897279-55911109 (-)
DBA/2J MGP_DBA2J_G0020391
 protein coding gene Chr13:49961086-49974916 (-)
FVB/NJ MGP_FVBNJ_G0020370
 protein coding gene Chr13:49405893-49419722 (-)
LP/J MGP_LPJ_G0020467
 protein coding gene Chr13:52542667-52556495 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020399
 protein coding gene Chr13:55489360-55502988 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020986
 protein coding gene Chr13:51437251-51451105 (-)
PWK/PhJ MGP_PWKPhJ_G0019578
 protein coding gene Chr13:49907367-49921328 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019405
 protein coding gene Chr13:50339236-50353034 (-)
WSB/EiJ MGP_WSBEiJ_G0019884
 protein coding gene Chr13:51751516-51765344 (-)



Homology
more
  • Human Ortholog
    NFIL3, nuclear factor, interleukin 3 regulated
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NFIL3, nuclear factor, interleukin 3 regulated
  • Synonyms
    E4BP4, IL3BP1, NF-IL3A, NFIL3A
  • Links
    NCBI Gene ID: 4783
    neXtProt AC: NX_Q16649
    UniProt: Q16649

  • Chr Location
    9q22.31; chr9:91409045-91483497 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Nfil3 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    57 phenotypes from 7 alleles in 10 genetic backgrounds
    8 phenotypes from multigenic genotypes
    81 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased NK cell differentiation, numbers, and activity. Mice homozygous for a different knock-out allele exhibit reduced class switching and IgE production.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1055
  • Tissues
    130
  • cDNA Data
    26
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000056749 Ensembl Gene Model | MGI Sequence Detail 13865 C57BL/6J ±  kb
    transcript ENSMUST00000071065 Ensembl | MGI Sequence Detail 2026 Not Applicable  
    polypeptide ENSMUSP00000065363 Ensembl | MGI Sequence Detail 462 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000011176 nuclear factor interleukin-3-regulated protein
      (term hierarchy)
    • InterPro Domains
      IPR004827 Basic-leucine zipper domain
      IPR046347 Basic-leucine zipper domain superfamily
      IPR016743 Nuclear factor interleukin-3-regulated protein
      IPR047229 Nuclear factor interleukin-3-regulated protein-like
      IPR047106 Nuclear factor interleukin-3-regulated protein-like , bZIP domain
      IPR010533 Vertebrate interleukin-3 regulated transcription factor
    Molecular
    Reagents
    less
    • All nucleic 29
      cDNA 26
      Primer pair 2
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-39494, MGI:2145396
    References
    more
    • Summaries
      All 137
      Developmental Gene Expression 11
      Diseases 1
      Gene Ontology 11
      Phenotypes 81
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:351164 Park J, et al., The transcription factor NFIL3/E4BP4 regulates the developmental stage-specific acquisition of basophil function. J Allergy Clin Immunol. 2024 Jan;153(1):132-145
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory