Dctn1 MGI Mouse Gene Detail - MGI:107745

Symbol

Dctn1
Name

dynactin 1
Synonyms

Glued, p150, p150^glued

Feature Type

protein coding gene
IDs

MGI:107745
NCBI Gene: 13191
Alliance

gene page
Transcription Start Sites

21 TSS

Sequence Map

Chr6:83142902-83177099 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 35.94 cM
Mapping Data

4 experiments

SNPs within 2kb

829 from dbSNP Build 142
Strain Annotations

18
RFLP

2

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_107745	protein coding gene	Chr6:83142702-83177103 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0030926	protein coding gene	Chr6:84172663-84207785 (+)
A/J	MGP_AJ_G0030895	protein coding gene	Chr6:80958455-80993953 (+)
AKR/J	MGP_AKRJ_G0030823	protein coding gene	Chr6:83292871-83326885 (+)
BALB/cJ	MGP_BALBcJ_G0030905	protein coding gene	Chr6:80978447-81013360 (+)
C3H/HeJ	MGP_C3HHeJ_G0030805	protein coding gene	Chr6:101059375-101093581 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0031365	protein coding gene	Chr6:86460200-86494406 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028551	protein coding gene	Chr6:79317524-79351680 (+)
CAST/EiJ	MGP_CASTEiJ_G0030014	protein coding gene	Chr6:83302371-83339240 (+)
CBA/J	MGP_CBAJ_G0030592	protein coding gene	Chr6:89878449-89915802 (+)
DBA/2J	MGP_DBA2J_G0030745	protein coding gene	Chr6:80277296-80311730 (+)
FVB/NJ	MGP_FVBNJ_G0030698	protein coding gene	Chr6:79484754-79519003 (+)
LP/J	MGP_LPJ_G0030824	protein coding gene	Chr6:84167497-84209341 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0030734	protein coding gene	Chr6:94188334-94225529 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0031389	protein coding gene	Chr6:83107752-83144325 (+)
PWK/PhJ	MGP_PWKPhJ_G0029729	protein coding gene	Chr6:79171387-79206320 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0029557	protein coding gene	Chr6:81951185-81985224 (+)
WSB/EiJ	MGP_WSBEiJ_G0030095	protein coding gene	Chr6:83542627-83577923 (+)

Human Ortholog

DCTN1, dynactin subunit 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DCTN1, dynactin subunit 1
Synonyms

DAP-150, DP-150, HMND14, P135
Links

HGNC:2711

NCBI Gene ID: 1639

neXtProt AC: NX_Q14203

UniProt: Q14203
Chr Location

2p13.1; chr2:74361154-74392087 (-) GRCh38

MGI Vertebrate Homology

Dctn1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: DCTN1
Gene Tree

Dctn1

Diseases

3 with human DCTN1 associations

				Human Disease	Mouse Models
				amyotrophic lateral sclerosis type 1 IDs amyotrophic lateral sclerosis type 1 DOID:0060193 ICD10CM:G12.2 OMIM:105400
				autosomal dominant distal hereditary motor neuronopathy 14 IDs autosomal dominant distal hereditary motor neuronopathy 14 DOID:0111202 OMIM:607641
				Perry syndrome IDs Perry syndrome DOID:0060486 MESH:C566822 OMIM:168605 ORDO:178509

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

22 phenotypes from 4 alleles in 3 genetic backgrounds
1 phenotype from multigenic genotypes
18 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

22
Endonuclease-mediated

3
Gene trapped

13
Spontaneous

1
Targeted

5
Genomic Mutations

2 involving Dctn1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

65 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit embryonic lethality and developmental arrest at E7.5 associated with increased apoptosis.

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All GO Annotations

105
GO References

23

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

719
Tissues

8
cDNA Data

207
Literature Summary

15

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase dctn1

ZFIN dctn1a, dctn1b

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All Sequences

118
RefSeq

46
UniProt

10
CCDS

CCDS39532.1, CCDS57432.1, CCDS57433.1

Ensembl

ENSMUSG00000031865 (Evidence)
NCBI Gene

13191

			Length	Strain/Species	Flank
genomic	ENSMUSG00000031865	Ensembl Gene Model \| MGI Sequence Detail	34198	C57BL/6J	± kb
transcript	ENSMUST00000113919	Ensembl \| MGI Sequence Detail	4292	Not Applicable
polypeptide	ENSMUSP00000109552	Ensembl \| MGI Sequence Detail	1281	Not Applicable

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UniProt

10 Sequences
Protein Ontology

PR:000006323 dynactin subunit 1

(term hierarchy)
InterPro Domains

IPR000938 CAP Gly-rich domain

IPR036859 CAP Gly-rich domain superfamily

IPR022157 Dynein associated protein
GlyGen

O08788 4 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (3 sites)

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All nucleic 212

Genomic 3

cDNA 209

Microarray probesets 3

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MGD-MRK-36321, MGI:2144338

Summaries

All 91

Developmental Gene Expression 15

Gene Ontology 23

Phenotypes 18
Earliest

J:34934 Vaughan KT, et al., Multiple mouse chromosomal loci for dynein-based motility. Genomics. 1996 Aug 15;36(1):29-38
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Dctn1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr57316	Chr6:83142902-83142959 (+)	29 bp
Tssr57317	Chr6:83156550-83156612 (+)	13,679 bp
Tssr57318	Chr6:83156619-83156632 (+)	13,724 bp
Tssr1906	Chr6:83156648-83156663 (+)	13,754 bp
Tssr57319	Chr6:83156683-83156684 (+)	13,782 bp
Tssr57320	Chr6:83163064-83163133 (+)	20,197 bp
Tssr57321	Chr6:83163142-83163164 (+)	20,251 bp
Tssr57322	Chr6:83163170-83163183 (+)	20,275 bp
Tssr57323	Chr6:83163310-83163331 (+)	20,419 bp
Tssr57324	Chr6:83165873-83165876 (+)	22,973 bp
Tssr57325	Chr6:83165877-83165885 (+)	22,979 bp
Tssr57326	Chr6:83165973-83165984 (+)	23,077 bp
Tssr57327	Chr6:83166043-83166062 (+)	23,151 bp
Tssr57328	Chr6:83166918-83166932 (+)	24,023 bp
Tssr57329	Chr6:83172791-83172807 (+)	29,897 bp
Tssr57330	Chr6:83172820-83172831 (+)	29,924 bp
Tssr57331	Chr6:83172858-83172863 (+)	29,959 bp
Tssr57332	Chr6:83172905-83172939 (+)	30,020 bp
Tssr57333	Chr6:83172942-83172959 (+)	30,049 bp
Tssr57334	Chr6:83172981-83172998 (+)	30,088 bp
Tssr57335	Chr6:83173007-83173016 (+)	30,110 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24