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Gfra2 Gene Detail
Summary
  • Symbol
    Gfra2
  • Name
    glial cell line derived neurotrophic factor family receptor alpha 2
  • Synonyms
    GFR alpha 2, GFR alpha-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1195462
    NCBI Gene: 14586
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:71127560-71217278 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 36.79 cM, cytoband D3-E1
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    2319 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1195462
 protein coding gene Chr14:71127547-71217280 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021551
 protein coding gene Chr14:65561565-65657848 (+)
A/J MGP_AJ_G0021510
 protein coding gene Chr14:64157117-64249769 (+)
AKR/J MGP_AKRJ_G0021486
 protein coding gene Chr14:66078960-66167095 (+)
BALB/cJ MGP_BALBcJ_G0021516
 protein coding gene Chr14:63922105-64014801 (+)
C3H/HeJ MGP_C3HHeJ_G0021293
 protein coding gene Chr14:65796385-65887355 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021955
 protein coding gene Chr14:68487585-68580739 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019495
 protein coding gene Chr14:61987598-62078085 (+)
CAST/EiJ MGP_CASTEiJ_G0020810
 protein coding gene Chr14:62390442-62483636 (+)
CBA/J MGP_CBAJ_G0021260
 protein coding gene Chr14:70632535-70733091 (+)
DBA/2J MGP_DBA2J_G0021383
 protein coding gene Chr14:63544520-63636890 (+)
FVB/NJ MGP_FVBNJ_G0021362
 protein coding gene Chr14:62972113-63060761 (+)
LP/J MGP_LPJ_G0021454
 protein coding gene Chr14:66792582-66881002 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021391
 protein coding gene Chr14:69512222-69605771 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021979
 protein coding gene Chr14:65343909-65436073 (+)
PWK/PhJ MGP_PWKPhJ_G0020554
 protein coding gene Chr14:60312635-60405192 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020387
 protein coding gene Chr14:61266521-61358186 (+)
WSB/EiJ MGP_WSBEiJ_G0020863
 protein coding gene Chr14:65657818-65749054 (+)



Homology
more
  • Human Ortholog
    GFRA2, GDNF family receptor alpha 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GFRA2, GDNF family receptor alpha 2
  • Synonyms
    GDNFRB, NRTNR-ALPHA, NTNRA, RETL2, TRNR2
  • Links
    NCBI Gene ID: 2675
    neXtProt AC: NX_O00451
    UniProt: O00451

  • Chr Location
    8p21.3; chr8:21690398-21812357 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    16 phenotypes from 2 alleles in 4 genetic backgrounds
    34 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutants have dry eyes, poor postweaning growth associated with impaired parasympathetic cholinergic innervation of lacrimal and salivary glands and of small intestine, reduced skin thickness and accelerated hair follicle regression.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    896
  • Tissues
    87
  • cDNA Data
    28
  • Literature Summary
    61
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022103 Ensembl Gene Model | MGI Sequence Detail 89719 C57BL/6J ±  kb
    transcript ENSMUST00000022699 Ensembl | MGI Sequence Detail 3472 Not Applicable  
    polypeptide ENSMUSP00000022699 Ensembl | MGI Sequence Detail 464 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000007949 GDNF family receptor alpha-2
      (term hierarchy)
    • InterPro Domains
      IPR016017 GDNF/GAS1
      IPR037193 GDNF receptor alpha
      IPR003438 Glial cell line-derived neurotrophic factor receptor
      IPR017372 Glial cell line-derived neurotrophic factor receptor, alpha 1/2
      IPR003504 Glial cell line-derived neurotrophic factor receptor alpha 2
    • GlyGen
      O08842 6 sites, 4 N-linked glycans (5 sites), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 51
      Genomic 3
      cDNA 31
      Primer pair 7
      Other 10

      Microarray probesets 6
    References
    more
    • Summaries
      All 119
      Developmental Gene Expression 61
      Gene Ontology 9
      Phenotypes 34
    • Earliest
      J:44407 Luukko K, et al., Expression of GDNF and its receptors in developing tooth is developmentally regulated and suggests multiple roles in innervation and organogenesis. Dev Dyn. 1997 Dec;210(4):463-71
    • Latest
      J:347711 Morikawa M, et al., Mesenchymal cells regulate enteric neural crest cell migration via RET-GFRA1b trans-signaling. Biochem Biophys Res Commun. 2024 May 28;710:149861
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory