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Ro60 Gene Detail
Summary
  • Symbol
    Ro60
  • Name
    Ro60, Y RNA binding protein
  • Synonyms
    1810007I17Rik, A530054J02Rik, Ssa, Ssa2, SS-A/Ro, Trove2
  • Feature Type
    protein coding gene
  • IDs
    MGI:106652
    NCBI Gene: 20822
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:143626528-143652794 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 62.54 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    807 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106652
 protein coding gene Chr1:143626528-143652806 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016563
 protein coding gene Chr1:148106617-148134529 (-)
A/J MGP_AJ_G0016546
 protein coding gene Chr1:142198744-142226678 (-)
AKR/J MGP_AKRJ_G0016511
 protein coding gene Chr1:146563932-146593216 (-)
BALB/cJ MGP_BALBcJ_G0016506
 protein coding gene Chr1:142623292-142650263 (-)
C3H/HeJ MGP_C3HHeJ_G0016331
 protein coding gene Chr1:146682018-146708456 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016967
 protein coding gene Chr1:153099507-153125733 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014676
 protein coding gene Chr1:135011598-135038074 (-)
CAST/EiJ MGP_CASTEiJ_G0015910
 protein coding gene Chr1:146103180-146130359 (-)
CBA/J MGP_CBAJ_G0016305
 protein coding gene Chr1:158539370-158570501 (-)
DBA/2J MGP_DBA2J_G0016411
 protein coding gene Chr1:141296616-141323501 (-)
FVB/NJ MGP_FVBNJ_G0016409
 protein coding gene Chr1:139788291-139814019 (-)
LP/J MGP_LPJ_G0016482
 protein coding gene Chr1:149121236-149148610 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016435
 protein coding gene Chr1:164970806-164997621 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017003
 protein coding gene Chr1:146293050-146319507 (-)
PWK/PhJ MGP_PWKPhJ_G0015696
 protein coding gene Chr1:140208540-140235173 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015483
 protein coding gene Chr1:145089641-145119853 (-)
WSB/EiJ MGP_WSBEiJ_G0015973
 protein coding gene Chr1:146330224-146356394 (-)



Homology
more
  • Human Ortholog
    RO60, Ro60, Y RNA binding protein
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RO60, Ro60, Y RNA binding protein
  • Synonyms
    RORNP, SSA2, TROVE2
  • Links
    NCBI Gene ID: 6738
    neXtProt AC: NX_P10155
    UniProt: P10155

  • Chr Location
    1q31.2; chr1:193059454-193091777 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Ro60 mouse models

Human Disease Mouse Models
      
IDs
 View 3 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 1 allele in 2 genetic backgrounds
    1 images
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant mice develop symptoms similar to those observed in patients with lupus, including increased photosensitivity and membranoproliferative glomerulonephritis. The production of autoantibodies is detected in both homozygous and heterozygous mutant mice.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    708
  • Tissues
    2
  • cDNA Data
    77
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20822 NCBI Gene Model | MGI Sequence Detail 26267 C57BL/6J ±  kb
    transcript NM_013835 RefSeq | MGI Sequence Detail 8736 ZRU/MplStud  
    polypeptide O08848 UniProt | EBI | MGI Sequence Detail 538 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 77
      cDNA 77

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGD-MRK-14606, MGD-MRK-35110, MGI:1916306, MGI:2138306, MGI:2443501, MGI:6276289
    References
    more
    • Summaries
      All 51
      Developmental Gene Expression 4
      Diseases 1
      Gene Ontology 9
      Phenotypes 12
    • Earliest
      J:32812 Keech CL, et al., Structural differences between the human and mouse 52-kD Ro autoantigens associated with poorly conserved autoantibody activity across species. Clin Exp Immunol. 1996 May;104(2):255-63
    • Latest
      J:321251 Yang N, et al., Adamts18 Deficiency Causes Spontaneous SMG Fibrogenesis in Adult Mice. J Dent Res. 2022 Feb;101(2):226-234
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory