Mapk12 MGI Mouse Gene Detail - MGI:1353438 - mitogen-activated protein kinase 12

Symbol

Mapk12
Name

mitogen-activated protein kinase 12
Synonyms

Erk6, P38gamma, Prkm12, Sapk3

Feature Type

protein coding gene
IDs

MGI:1353438
NCBI Gene: 29857
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr15:89014787-89024906 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 44.65 cM
Mapping Data

2 experiments

SNPs within 2kb

232 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1353438	protein coding gene	Chr15:89014787-89025270 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0022219	protein coding gene	Chr15:90305330-90315341 (-)
A/J	MGP_AJ_G0022178	protein coding gene	Chr15:86853915-86864249 (-)
AKR/J	MGP_AKRJ_G0022153	protein coding gene	Chr15:89420524-89430549 (-)
BALB/cJ	MGP_BALBcJ_G0022184	protein coding gene	Chr15:86952350-86963984 (-)
C3H/HeJ	MGP_C3HHeJ_G0021954	protein coding gene	Chr15:89407736-89418578 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0022629	protein coding gene	Chr15:93586581-93596758 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020154	protein coding gene	Chr15:83077079-83087211 (-)
CAST/EiJ	MGP_CASTEiJ_G0021476	protein coding gene	Chr15:90186746-90202759 (-)
CBA/J	MGP_CBAJ_G0021921	protein coding gene	Chr15:96747102-96757593 (-)
DBA/2J	MGP_DBA2J_G0022048	protein coding gene	Chr15:86306299-86316666 (-)
FVB/NJ	MGP_FVBNJ_G0022027	protein coding gene	Chr15:85371134-85381049 (-)
LP/J	MGP_LPJ_G0022119	protein coding gene	Chr15:90463752-90473803 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022047	protein coding gene	Chr15:101169615-101180967 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022644	protein coding gene	Chr15:89454989-89466142 (-)
PWK/PhJ	MGP_PWKPhJ_G0021217	protein coding gene	Chr15:86350748-86360696 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0021051	protein coding gene	Chr15:89188589-89199777 (-)
WSB/EiJ	MGP_WSBEiJ_G0021525	protein coding gene	Chr15:89940916-89952616 (-)

Human Ortholog

MAPK12, mitogen-activated protein kinase 12

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MAPK12, mitogen-activated protein kinase 12
Synonyms

ERK3, ERK-6, ERK6, MAPK 12, P38GAMMA, PRKM12, SAPK-3, SAPK3
Links

HGNC:6874

NCBI Gene ID: 6300

neXtProt AC: NX_P53778

UniProt: P53778
Chr Location

22q13.33; chr22:50245450-50261716 (-) GRCh38

MGI Vertebrate Homology

Mapk12 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: MAPK12
Gene Tree

Mapk12

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References

1 with disease annotations

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Phenotype Summary

4 phenotypes from 3 alleles in 3 genetic backgrounds
1 phenotype from multigenic genotypes
48 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Chemically induced (other)

1
Endonuclease-mediated

4
Radiation induced

2
Targeted

4
Genomic Mutations

3 involving Mapk12
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

17 strains or lines available

Homozygous null mice are viable and fertile with no obvious abnormalities. Mice homozygous for a conditional allele activated in muscle cell exhibit decreased endurance exercise-induced mitochondrial biogenesis and angiogenesis.

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All GO Annotations

21
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

754
Tissues

19
cDNA Data

31
Literature Summary

9

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase mapk12

ZFIN mapk12a, mapk12b

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All Sequences

66
RefSeq

18
UniProt

2
CCDS

CCDS27740.1

Ensembl

ENSMUSG00000022610 (Evidence)
NCBI Gene

29857

			Length	Strain/Species	Flank
genomic	ENSMUSG00000022610	Ensembl Gene Model \| MGI Sequence Detail	10120	C57BL/6J	± kb
transcript	ENSMUST00000088827	Ensembl \| MGI Sequence Detail	1808	Not Applicable
polypeptide	ENSMUSP00000086207	Ensembl \| MGI Sequence Detail	367	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000010153 mitogen-activated protein kinase 12

(term hierarchy)
EC

2.7.11.24
InterPro Domains

IPR050117 Mitogen-activated protein kinase

IPR038786 Mitogen-activated protein kinase 12

IPR003527 Mitogen-activated protein (MAP) kinase, conserved site

IPR008352 Mitogen-activated protein (MAP) kinase p38-like

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

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All nucleic 33

cDNA 31

Primer pair 1

Other 1

Microarray probesets 4

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MGI:2146196

Summaries

All 94

Developmental Gene Expression 9

Diseases 1

Gene Ontology 8

Phenotypes 48
Earliest

J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
Latest

J:343362 Diaz-Mora E, et al., p38delta controls Mitogen- and Stress-activated Kinase-1 (MSK1) function in response to toll-like receptor activation in macrophages. Front Cell Dev Biol. 2023;11:1083033

TSS for Mapk12:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr135841	Chr15:89024867-89024899 (-)	23 bp
Tssr135840	Chr15:89021785-89021803 (-)	3,112 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24