Slc22a1 MGI Mouse Gene Detail - MGI:108111 - solute carrier family 22 (organic cation transporter), member 1

Symbol

Slc22a1
Name

solute carrier family 22 (organic cation transporter), member 1
Synonyms

Lx1, MGC:14019, Oct1, Oct1, Orct, Orct1

Feature Type

protein coding gene
IDs

MGI:108111
NCBI Gene: 20517
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr17:12867756-12894716 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 8.63 cM
Mapping Data

10 experiments

SNPs within 2kb

569 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_108111	protein coding gene	Chr17:12867756-12894725 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0023148	protein coding gene	Chr17:10312412-10339104 (-)
A/J	MGP_AJ_G0023116	protein coding gene	Chr17:10139649-10167369 (-)
AKR/J	MGP_AKRJ_G0023080	protein coding gene	Chr17:9968471-9995315 (-)
BALB/cJ	MGP_BALBcJ_G0023116	protein coding gene	Chr17:9916250-9944075 (-)
C3H/HeJ	MGP_C3HHeJ_G0022879	protein coding gene	Chr17:10214085-10243808 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0023559	protein coding gene	Chr17:10703587-10730026 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021049	protein coding gene	Chr17:4277304-4303806 (+)
CAST/EiJ	MGP_CASTEiJ_G0022393	protein coding gene	Chr17:10294794-10326474 (-)
CBA/J	MGP_CBAJ_G0022851	protein coding gene	Chr17:11098187-11133562 (-)
DBA/2J	MGP_DBA2J_G0022984	protein coding gene	Chr17:9777173-9809532 (-)
FVB/NJ	MGP_FVBNJ_G0022954	protein coding gene	Chr17:9716374-9743091 (-)
LP/J	MGP_LPJ_G0023056	protein coding gene	Chr17:10127697-10155803 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022973	protein coding gene	Chr17:10705880-10736731 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023585	protein coding gene	Chr17:10235818-10265277 (-)
PWK/PhJ	MGP_PWKPhJ_G0022141	protein coding gene	Chr17:9470905-9498836 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0021971	protein coding gene	Chr17:9665834-9694784 (-)
WSB/EiJ	MGP_WSBEiJ_G0022450	protein coding gene	Chr17:10555332-10585827 (-)

Human Ortholog

SLC22A1, solute carrier family 22 member 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SLC22A1, solute carrier family 22 member 1
Synonyms

HOCT1, OCT1, oct1_cds
Links

HGNC:10963

NCBI Gene ID: 6580

neXtProt AC: NX_O15245

UniProt: O15245
Chr Location

6q25.3; chr6:160121815-160158718 (+) GRCh38

MGI Vertebrate Homology

Slc22a1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SLC22A1
Gene Tree

Slc22a1

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Phenotype Summary

8 phenotypes from 2 alleles in 2 genetic backgrounds
1 phenotype from multigenic genotypes
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Endonuclease-mediated

5
Targeted

4
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

31 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knockout allele are viable, healthy, and fertile but exhibit an impaired liver uptake and direct intestinal excretion of substrate organic cations. Mice homozygous for a different knockout allele show alterations in metformin disposition and its glucose-lowering effects.

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All GO Annotations

110
GO References

15

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

767
Tissues

33
cDNA Data

88
Literature Summary

11

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

33
RefSeq

2
UniProt

2
CCDS

CCDS28393.1

Ensembl

ENSMUSG00000023829 (Evidence)
NCBI Gene

20517

			Length	Strain/Species	Flank
genomic	ENSMUSG00000023829	Ensembl Gene Model \| MGI Sequence Detail	26961	C57BL/6J	± kb
transcript	ENSMUST00000024596	Ensembl \| MGI Sequence Detail	1985	Not Applicable
polypeptide	ENSMUSP00000024596	Ensembl \| MGI Sequence Detail	556	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000014981 solute carrier family 22 member 1

(term hierarchy)
InterPro Domains

IPR005828 Major facilitator, sugar transporter-like

IPR020846 Major facilitator superfamily domain

IPR036259 MFS transporter superfamily

IPR004749 Organic cation transport protein/SVOP

IPR005829 Sugar transporter, conserved site
GlyGen

O08966 1 site

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All nucleic 100

Genomic 4

cDNA 89

Primer pair 6

Other 1

Microarray probesets 3

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MGD-MRK-37054, MGD-MRK-37148

Summaries

All 74

Developmental Gene Expression 11

Gene Ontology 15

Phenotypes 15
Earliest

J:35906 Schweifer N, et al., The Lx1 gene maps to mouse chromosome 17 and codes for a protein that is homologous to glucose and polyspecific transmembrane transporters. Mamm Genome. 1996 Oct;7(10):735-40
Latest

J:339165 Hucke A, et al., Role of Mouse Organic Cation Transporter 2 for Nephro- and Peripheral Neurotoxicity Induced by Chemotherapeutic Treatment with Cisplatin. Int J Mol Sci. 2023 Jul 14;24(14)

TSS for Slc22a1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr146438	Chr17:12894720-12894731 (-)	-10 bp
Tssr146437	Chr17:12894673-12894694 (-)	32 bp
Tssr146436	Chr17:12894629-12894662 (-)	70 bp
Tssr146435	Chr17:12894615-12894626 (-)	95 bp
Tssr146434	Chr17:12894585-12894601 (-)	123 bp
Tssr146433	Chr17:12893690-12893694 (-)	1,024 bp
Tssr146432	Chr17:12871626-12871640 (-)	23,083 bp
Tssr146431	Chr17:12871557-12871566 (-)	23,154 bp
Tssr146430	Chr17:12871528-12871539 (-)	23,182 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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