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C3ar1 Gene Detail
Summary
  • Symbol
    C3ar1
  • Name
    complement component 3a receptor 1
  • Synonyms
    anaphylatoxin C3a receptor, C3aR
  • Feature Type
    protein coding gene
  • IDs
    MGI:1097680
    NCBI Gene: 12267
  • Alliance
    gene page
  • Transcription Start Sites
    43 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:122824099-122833116 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 57.93 cM, cytoband F1
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    290 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1097680
 protein coding gene Chr6:122824097-122833120 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031234
 protein coding gene Chr6:125970570-125979598 (-)
A/J MGP_AJ_G0031203
 protein coding gene Chr6:121197780-121206808 (-)
AKR/J MGP_AKRJ_G0031133
 protein coding gene Chr6:124550548-124559576 (-)
BALB/cJ MGP_BALBcJ_G0031213
 protein coding gene Chr6:120909476-120918504 (-)
C3H/HeJ MGP_C3HHeJ_G0030932
 protein coding gene Chr6:124520666-124530203 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031672
 protein coding gene Chr6:129295401-129304424 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028829
 protein coding gene Chr6:117797990-117806809 (-)
CAST/EiJ MGP_CASTEiJ_G0030321
 protein coding gene Chr6:124779042-124788750 (-)
CBA/J MGP_CBAJ_G0030895
 protein coding gene Chr6:134329556-134338589 (-)
DBA/2J MGP_DBA2J_G0031051
 protein coding gene Chr6:120124350-120133378 (-)
FVB/NJ MGP_FVBNJ_G0031004
 protein coding gene Chr6:119061280-119070295 (-)
LP/J MGP_LPJ_G0031132
 protein coding gene Chr6:126161429-126170457 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031039
 protein coding gene Chr6:138287328-138296341 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031702
 protein coding gene Chr6:124441274-124450312 (-)
PWK/PhJ MGP_PWKPhJ_G0030035
 protein coding gene Chr6:118967284-118976550 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029863
 protein coding gene Chr6:122586398-122594924 (-)
WSB/EiJ MGP_WSBEiJ_G0030403
 protein coding gene Chr6:124759246-124768254 (-)



Homology
more
  • Human Ortholog
    C3AR1, complement C3a receptor 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    C3AR1, complement C3a receptor 1
  • Synonyms
    AZ3B, C3AR, HNFAG09
  • Links
    NCBI Gene ID: 719
    neXtProt AC: NX_Q16581
    UniProt: Q16581

  • Chr Location
    12p13.31; chr12:8056844-8066359 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human C3AR1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    42 phenotypes from 4 alleles in 7 genetic backgrounds
    16 phenotypes from multigenic genotypes
    124 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous targeted mutants display protective effects against the changes in lung physiology after allergen challenge, increased lethality to endotoxin shock, and elevated IL1B following LPS challenge, supporting the role of C3arin proinflammatory responses.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    32
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    727
  • Tissues
    13
  • cDNA Data
    30
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12267 NCBI Gene Model | MGI Sequence Detail 9018 C57BL/6J ±  kb
    transcript NM_009779 RefSeq | MGI Sequence Detail 4299 C57BL/6  
    polypeptide O09047 UniProt | EBI | MGI Sequence Detail 477 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 36
      Genomic 3
      cDNA 31
      Primer pair 2

      Microarray probesets 5
    References
    more
    • Summaries
      All 170
      Developmental Gene Expression 7
      Gene Ontology 7
      Phenotypes 124
    • Earliest
      J:40631 Tornetta MA, et al., The mouse anaphylatoxin C3a receptor: molecular cloning, genomic organization, and functional expression. J Immunol. 1997 Jun 1;158(11):5277-82
    • Latest
      J:354496 Stark K, et al., Antibodies and complement are key drivers of thrombosis. Immunity. 2024 Sep 10;57(9):2140-2156.e10
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/22/2024
    MGI 6.24     		The Jackson Laboratory