Guca2b MGI Mouse Gene Detail - MGI:1270851 - guanylate cyclase activator 2b

Symbol

Guca2b
Name

guanylate cyclase activator 2b
Synonyms

Gcap2, uroguanylin

Feature Type

protein coding gene
IDs

MGI:1270851
NCBI Gene: 14916
Alliance

gene page
Transcription Start Sites

12 TSS

Sequence Map

Chr4:119513798-119516142 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 55.48 cM
Mapping Data

4 experiments

SNPs within 2kb

164 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1270851	protein coding gene	Chr4:119513798-119516151 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0028704	protein coding gene	Chr4:120857413-120859674 (-)
A/J	MGP_AJ_G0028664	protein coding gene	Chr4:116110690-116113991 (-)
AKR/J	MGP_AKRJ_G0028617	protein coding gene	Chr4:118643083-118645380 (-)
BALB/cJ	MGP_BALBcJ_G0028687	protein coding gene	Chr4:116739548-116741849 (-)
C3H/HeJ	MGP_C3HHeJ_G0028402	protein coding gene	Chr4:120199434-120202459 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0029128	protein coding gene	Chr4:125447332-125449628 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026405	protein coding gene	Chr4:110204801-110207028 (-)
CAST/EiJ	MGP_CASTEiJ_G0027833	protein coding gene	Chr4:117523876-117527384 (-)
CBA/J	MGP_CBAJ_G0028369	protein coding gene	Chr4:128844768-128848443 (-)
DBA/2J	MGP_DBA2J_G0028516	protein coding gene	Chr4:116699886-116702443 (-)
FVB/NJ	MGP_FVBNJ_G0028482	protein coding gene	Chr4:115217521-115220385 (-)
LP/J	MGP_LPJ_G0028616	protein coding gene	Chr4:120982980-120986288 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028510	protein coding gene	Chr4:133734195-133738590 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029165	protein coding gene	Chr4:119711448-119715020 (-)
PWK/PhJ	MGP_PWKPhJ_G0027556	protein coding gene	Chr4:113628075-113630745 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0027382	protein coding gene	Chr4:116151492-116153752 (-)
WSB/EiJ	MGP_WSBEiJ_G0027913	protein coding gene	Chr4:119720121-119723984 (-)

Human Ortholog

GUCA2B, guanylate cyclase activator 2B

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GUCA2B, guanylate cyclase activator 2B
Synonyms

GCAP-II, UGN
Links

HGNC:4683

NCBI Gene ID: 2981

neXtProt AC: NX_Q16661

UniProt: Q16661
Chr Location

1p34.2; chr1:42153410-42155820 (+) GRCh38

MGI Vertebrate Homology

Guca2b stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: GUCA2B
Protein SuperFamily

Guanylin
Gene Tree

Guca2b

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Phenotype Summary

8 phenotypes from 1 allele in 1 genetic background
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Chemically induced (other)

2
Radiation induced

1
Targeted

2
Genomic Mutations

4 involving Guca2b
Find Mice (IMSR)

7 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygotes for a targeted null mutation exhibit elevated blood pressure, increased sodium levels, and reduced sodium, potassium, and fluid excretion following salt loading.

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All GO Annotations

13
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

42

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

39
RefSeq

2
UniProt

3
CCDS

CCDS18587.1

Ensembl

ENSMUSG00000032978 (Evidence)
NCBI Gene

14916

			Length	Strain/Species	Flank
genomic	14916	NCBI Gene Model \| MGI Sequence Detail	2345	C57BL/6J	± kb
transcript	NM_008191	RefSeq \| MGI Sequence Detail	602	C57BL/6
polypeptide	O09051	UniProt \| EBI \| MGI Sequence Detail	106	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000008347 guanylate cyclase activator 2B

(term hierarchy)
InterPro Domains

IPR000879 Guanylin

IPR036382 Guanylin superfamily

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All nucleic 45

Genomic 3

cDNA 42

Microarray probesets 3

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MGI:1354183, MGI:2140522

Summaries

All 43

Gene Ontology 6

Phenotypes 11
Earliest

J:19885 Kambouris M, et al., Novel cDNA clones obtained by antibody screening of a mouse cerebellar cDNA expression library. Brain Res Mol Brain Res. 1994 Sep;25(3-4):183-91
Latest

J:338998 Ratko M, et al., Role of uroguanylin's signalling pathway in the development of ischaemic stroke. Eur J Neurosci. 2022 Jul;56(1):3720-3737

TSS for Guca2b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr43138	Chr4:119516103-119516119 (-)	31 bp
Tssr43137	Chr4:119515828-119515843 (-)	306 bp
Tssr43136	Chr4:119515311-119515325 (-)	824 bp
Tssr43135	Chr4:119515285-119515305 (-)	847 bp
Tssr43134	Chr4:119514844-119514862 (-)	1,289 bp
Tssr43133	Chr4:119514814-119514833 (-)	1,318 bp
Tssr43132	Chr4:119514791-119514810 (-)	1,341 bp
Tssr43131	Chr4:119514758-119514773 (-)	1,376 bp
Tssr43130	Chr4:119513963-119513974 (-)	2,173 bp
Tssr43129	Chr4:119513936-119513959 (-)	2,194 bp
Tssr43128	Chr4:119513906-119513916 (-)	2,231 bp
Tssr43127	Chr4:119513832-119513845 (-)	2,303 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 10/29/2024 MGI 6.24