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Wrn Gene Detail
Summary
  • Symbol
    Wrn
  • Name
    Werner syndrome RecQ like helicase
  • Feature Type
    protein coding gene
  • IDs
    MGI:109635
    NCBI Gene: 22427
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:33724412-33875555 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 20.30 cM, cytoband A4
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4473 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109635
 protein coding gene Chr8:33724400-33875591 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033520
 protein coding gene Chr8:31683996-31839922 (-)
A/J MGP_AJ_G0033500
 protein coding gene Chr8:30468872-30620303 (-)
AKR/J MGP_AKRJ_G0033424
 protein coding gene Chr8:31420136-31575516 (-)
BALB/cJ MGP_BALBcJ_G0033496
 protein coding gene Chr8:30582836-30741728 (-)
C3H/HeJ MGP_C3HHeJ_G0033208
 protein coding gene Chr8:31737534-31897512 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034012
 protein coding gene Chr8:32909875-33064951 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030961
 protein coding gene Chr8:27277085-27421103 (-)
CAST/EiJ MGP_CASTEiJ_G0032535
 protein coding gene Chr8:31159689-31326550 (-)
CBA/J MGP_CBAJ_G0033186
 protein coding gene Chr8:34185677-34368707 (-)
DBA/2J MGP_DBA2J_G0033339
 protein coding gene Chr8:30445475-30601063 (-)
FVB/NJ MGP_FVBNJ_G0033284
 protein coding gene Chr8:30122931-30265024 (-)
LP/J MGP_LPJ_G0033429
 protein coding gene Chr8:31642899-31795898 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033326
 protein coding gene Chr8:33731756-33905180 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034031
 protein coding gene Chr8:31491973-31658496 (-)
PWK/PhJ MGP_PWKPhJ_G0032247
 protein coding gene Chr8:29957287-30115564 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032079
 protein coding gene Chr8:30778819-30950134 (-)
WSB/EiJ MGP_WSBEiJ_G0032651
 protein coding gene Chr8:31634793-31798964 (-)



Homology
more
  • Human Ortholog
    WRN, WRN RecQ like helicase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    WRN, WRN RecQ like helicase
  • Synonyms
    RECQ3, RECQL2, RECQL3
  • Links
    NCBI Gene ID: 7486
    neXtProt AC: NX_Q14191
    UniProt: Q14191

  • Chr Location
    8p12; chr8:31033788-31176138 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Wrn mouse models; 6 with human WRN associations

Human Disease Mouse Models
      
IDs
 View 2 models
      
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    31 phenotypes from 3 alleles in 6 genetic backgrounds
    41 phenotypes from multigenic genotypes
    33 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutants show enhanced frequency and variety of tumors in conjunction with Trp53 knockout alleles. Homozygotes also have an elevated frequency of somatic reversion of the pink-eyed dilution unstable mutation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    111
  • GO References
    19
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    714
  • Tissues
    4
  • cDNA Data
    44
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031583 Ensembl Gene Model | MGI Sequence Detail 151144 C57BL/6J ±  kb
    transcript ENSMUST00000033990 Ensembl | MGI Sequence Detail 5019 Not Applicable  
    polypeptide ENSMUSP00000033990 Ensembl | MGI Sequence Detail 1401 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 51
      Genomic 3
      cDNA 45
      Primer pair 2
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-39634, MGI:2142626
    References
    more
    • Summaries
      All 78
      Developmental Gene Expression 2
      Diseases 3
      Gene Ontology 19
      Phenotypes 33
    • Earliest
      J:46871 Yu CE, et al., Positional cloning of the Werner's syndrome gene [see comments]. Science. 1996 Apr 12;272(5259):258-62
    • Latest
      J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/29/2024
    MGI 6.24     		The Jackson Laboratory