Kif3c MGI Mouse Gene Detail - MGI:107979 - kinesin family member 3C

Symbol

Kif3c
Name

kinesin family member 3C
Synonyms

N-4 kinesin

Feature Type

protein coding gene
IDs

MGI:107979
NCBI Gene: 16570
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr12:3415132-3456494 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 1.77 cM
Mapping Data

5 experiments

SNPs within 2kb

867 from dbSNP Build 142
Strain Annotations

18
PCR

1
RFLP

2

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_107979	protein coding gene	Chr12:3415132-3456494 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019556	protein coding gene	Chr12:157056-200109 (+)
A/J	MGP_AJ_G0019523	protein coding gene	Chr12:227086-271895 (+)
AKR/J	MGP_AKRJ_G0019493	protein coding gene	Chr12:348493-392046 (+)
BALB/cJ	MGP_BALBcJ_G0019498	protein coding gene	Chr12:225107-270837 (+)
C3H/HeJ	MGP_C3HHeJ_G0019304	protein coding gene	Chr12:131049-175243 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019948	protein coding gene	Chr12:170255-211590 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017572	protein coding gene	Chr12:163259-203866 (+)
CAST/EiJ	MGP_CASTEiJ_G0018859	protein coding gene	Chr12:188624-228726 (+)
CBA/J	MGP_CBAJ_G0019275	protein coding gene	Chr12:375895-420990 (+)
DBA/2J	MGP_DBA2J_G0019388	protein coding gene	Chr12:181166-221668 (+)
FVB/NJ	MGP_FVBNJ_G0019379	protein coding gene	Chr12:198006-240636 (+)
LP/J	MGP_LPJ_G0019459	protein coding gene	Chr12:175847-222031 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019412	protein coding gene	Chr12:202090-243896 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019986	protein coding gene	Chr12:129890-169019 (+)
PWK/PhJ	MGP_PWKPhJ_G0018625	protein coding gene	Chr12:189190-231941 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018416	protein coding gene	Chr12:197281-239915 (+)
WSB/EiJ	MGP_WSBEiJ_G0018911	protein coding gene	Chr12:170057-212724 (+)

Human Ortholog

KIF3C, kinesin family member 3C

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

KIF3C, kinesin family member 3C
Links

HGNC:6321

NCBI Gene ID: 3797

neXtProt AC: NX_O14782

UniProt: O14782
Chr Location

2p23.3; chr2:25926598-25982749 (-) GRCh38

MGI Vertebrate Homology

Kif3c stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: KIF3C
Gene Tree

Kif3c

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Phenotype Summary

5 phenotypes from 4 alleles in 2 genetic backgrounds
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Gene trapped

1
Targeted

5
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

24 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for disruptions in this gene display a normal phenotype.

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All GO Annotations

25
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

893
Tissues

71
cDNA Data

10
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase kif3c

ZFIN kif3cb

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All Sequences

60
RefSeq

2
UniProt

5
CCDS

CCDS25783.1

Ensembl

ENSMUSG00000020668 (Evidence)
NCBI Gene

16570

			Length	Strain/Species	Flank
genomic	16570	NCBI Gene Model \| MGI Sequence Detail	41363	C57BL/6J	± kb
transcript	NM_008445	RefSeq \| MGI Sequence Detail	6849	ZRU/MplStud
polypeptide	O35066	UniProt \| EBI \| MGI Sequence Detail	796	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000009313 kinesin-like protein KIF3C

(term hierarchy)
PDB

5JVM
InterPro Domains

IPR027640 Kinesin-like protein

IPR001752 Kinesin motor domain

IPR019821 Kinesin motor domain, conserved site

IPR036961 Kinesin motor domain superfamily

IPR027417 P-loop containing nucleoside triphosphate hydrolase
GlyGen

O35066 1 site, 1 O-linked glycan (1 site)

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All nucleic 14

cDNA 11

Primer pair 2

Other 1

Microarray probesets 4

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MGD-MRK-36559

Summaries

All 43

Developmental Gene Expression 4

Gene Ontology 5

Phenotypes 9
Earliest

J:42822 Nakagawa T, et al., Identification and classification of 16 new kinesin superfamily (KIF) proteins in mouse genome. Proc Natl Acad Sci U S A. 1997 Sep 2;94(18):9654-9
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Kif3c:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr112482	Chr12:3415108-3415142 (+)	-7 bp
Tssr112483	Chr12:3415143-3415207 (+)	43 bp
Tssr112484	Chr12:3415218-3415229 (+)	92 bp
Tssr112485	Chr12:3415290-3415359 (+)	193 bp
Tssr112486	Chr12:3415385-3415405 (+)	263 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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