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Gfra3 Gene Detail
Summary
  • Symbol
    Gfra3
  • Name
    glial cell line derived neurotrophic factor family receptor alpha 3
  • Synonyms
    GFR alpha-3, GFRalpha3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1201403
    NCBI Gene: 14587
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:34822951-34853440 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 18.69 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    970 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1201403
 protein coding gene Chr18:34822951-34853440 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024247
 protein coding gene Chr18:32916817-32949875 (-)
A/J MGP_AJ_G0024213
 protein coding gene Chr18:31804807-31835145 (-)
AKR/J MGP_AKRJ_G0024182
 protein coding gene Chr18:32714375-32748473 (-)
BALB/cJ MGP_BALBcJ_G0024213
 protein coding gene Chr18:31861949-31892962 (-)
C3H/HeJ MGP_C3HHeJ_G0023981
 protein coding gene Chr18:32731460-32763351 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024655
 protein coding gene Chr18:34177869-34224268 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022096
 protein coding gene Chr18:31947480-31978389 (-)
CAST/EiJ MGP_CASTEiJ_G0023456
 protein coding gene Chr18:32677044-32716642 (-)
CBA/J MGP_CBAJ_G0023949
 protein coding gene Chr18:35116094-35153804 (-)
DBA/2J MGP_DBA2J_G0024081
 protein coding gene Chr18:31459228-31491536 (-)
FVB/NJ MGP_FVBNJ_G0024047
 protein coding gene Chr18:31146256-31176256 (-)
LP/J MGP_LPJ_G0024162
 protein coding gene Chr18:33001429-33035801 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024075
 protein coding gene Chr18:36378583-36412772 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024703
 protein coding gene Chr18:32534925-32567305 (-)
PWK/PhJ MGP_PWKPhJ_G0023199
 protein coding gene Chr18:31659757-31692383 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023008
 protein coding gene Chr18:32815628-32843340 (-)
WSB/EiJ MGP_WSBEiJ_G0023519
 protein coding gene Chr18:32461522-32496552 (-)



Homology
more
  • Human Ortholog
    GFRA3, GDNF family receptor alpha 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GFRA3, GDNF family receptor alpha 3
  • Synonyms
    GDNFR3
  • Links
    NCBI Gene ID: 2676
    neXtProt AC: NX_O60609
    UniProt: O60609

  • Chr Location
    5q31.2; chr5:138252380-138274621 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 4 alleles in 4 genetic backgrounds
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruption of this gene display ptosis and poor development of the sympathetic chain ganglia and associated nerves.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    23
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    843
  • Tissues
    87
  • cDNA Data
    23
  • Literature Summary
    29
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14587 NCBI Gene Model | MGI Sequence Detail 30490 C57BL/6J ±  kb
    transcript NM_010280 RefSeq | MGI Sequence Detail 1997 C57BL/6  
    polypeptide O35118 UniProt | EBI | MGI Sequence Detail 397 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 35
      Genomic 1
      cDNA 25
      Primer pair 4
      Other 5

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2147424
    References
    more
    • Summaries
      All 67
      Developmental Gene Expression 29
      Gene Ontology 9
      Phenotypes 18
    • Earliest
      J:45661 Naveilhan P, et al., Expression and regulation of GFRalpha3, a glial cell line-derived neurotrophic factor family receptor. Proc Natl Acad Sci U S A. 1998 Feb 3;95(3):1295-300
    • Latest
      J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory