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Tnfsf11 Gene Detail
Summary
  • Symbol
    Tnfsf11
  • Name
    tumor necrosis factor (ligand) superfamily, member 11
  • Synonyms
    Ly109l, ODF, OPGL, OPGL, osteoclast differentiation factor, RANKL, Trance
  • Feature Type
    protein coding gene
  • IDs
    MGI:1100089
    NCBI Gene: 21943
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:78514886-78545483 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 41.26 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    894 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1100089
 protein coding gene Chr14:78514885-78545483 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021589
 protein coding gene Chr14:73325283-73359953 (-)
A/J MGP_AJ_G0021547
 protein coding gene Chr14:71555488-71585791 (-)
AKR/J MGP_AKRJ_G0021524
 protein coding gene Chr14:73681845-73712301 (-)
BALB/cJ MGP_BALBcJ_G0021554
 protein coding gene Chr14:71378998-71410064 (-)
C3H/HeJ MGP_C3HHeJ_G0021331
 protein coding gene Chr14:73399868-73431384 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021994
 protein coding gene Chr14:76445484-76476064 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019532
 protein coding gene Chr14:69129871-69160841 (-)
CAST/EiJ MGP_CASTEiJ_G0020848
 protein coding gene Chr14:70189993-70228946 (-)
CBA/J MGP_CBAJ_G0021299
 protein coding gene Chr14:78892984-78926572 (-)
DBA/2J MGP_DBA2J_G0021422
 protein coding gene Chr14:70949705-70980143 (-)
FVB/NJ MGP_FVBNJ_G0021400
 protein coding gene Chr14:70292880-70323859 (-)
LP/J MGP_LPJ_G0021492
 protein coding gene Chr14:74432237-74464862 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021427
 protein coding gene Chr14:77569943-77600867 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022017
 protein coding gene Chr14:72968624-73000325 (-)
PWK/PhJ MGP_PWKPhJ_G0020591
 protein coding gene Chr14:67730532-67761481 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020428
 protein coding gene Chr14:68955333-68985768 (-)
WSB/EiJ MGP_WSBEiJ_G0020901
 protein coding gene Chr14:73307841-73338028 (-)



Homology
more
  • Human Ortholog
    TNFSF11, TNF superfamily member 11
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TNFSF11, TNF superfamily member 11
  • Synonyms
    CD254, hRANKL2, ODF, OPGL, OPTB2, RANKL, sOdf, TNLG6B, TRANCE
  • Links
    NCBI Gene ID: 8600
    neXtProt AC: NX_O14788
    UniProt: O14788

  • Chr Location
    13q14.11; chr13:42562736-42608013 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with Tnfsf11 mouse models; 2 with human TNFSF11 associations

Human Disease Mouse Models
      
IDs
 View 3 models
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    4 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    125 phenotypes from 10 alleles in 16 genetic backgrounds
    22 phenotypes from multigenic genotypes
    4 images
    93 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit a failure of tooth eruption, osteopetrosis, failure to lactate and arrested alveolar bud differentiation during pregnancy.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    82
  • GO References
    41
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    792
  • Tissues
    40
  • cDNA Data
    13
  • Literature Summary
    61
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 21943 NCBI Gene Model | MGI Sequence Detail 30598 C57BL/6J ±  kb
    transcript NM_011613 RefSeq | MGI Sequence Detail 2235 ZRU/MplStud  
    polypeptide O35235 UniProt | EBI | MGI Sequence Detail 316 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 27
      Genomic 1
      cDNA 15
      Primer pair 11

      Microarray probesets 4
    References
    more
    • Summaries
      All 418
      Developmental Gene Expression 61
      Diseases 4
      Gene Ontology 41
      Phenotypes 93
    • Earliest
      J:43257 Wong BR, et al., TRANCE is a novel ligand of the tumor necrosis factor receptor family that activates c-Jun N-terminal kinase in T cells. J Biol Chem. 1997 Oct 3;272(40):25190-4
    • Latest
      J:358999 Zhao X, et al., The histone methyltransferase ASH1L protects against bone loss by inhibiting osteoclastogenesis. Cell Death Differ. 2024 Mar 2;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory