About   Help   FAQ
Pdyn Gene Detail
Summary
  • Symbol
    Pdyn
  • Name
    prodynorphin
  • Synonyms
    Dyn
  • Feature Type
    protein coding gene
  • IDs
    MGI:97535
    NCBI Gene: 18610
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:129528485-129541764 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 63.19 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    482 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97535
 protein coding gene Chr2:129528469-129541858 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026491
 protein coding gene Chr2:133094085-133107378 (-)
A/J MGP_AJ_G0026455
 protein coding gene Chr2:127693099-127706377 (-)
AKR/J MGP_AKRJ_G0026430
 protein coding gene Chr2:131319678-131332969 (-)
BALB/cJ MGP_BALBcJ_G0026467
 protein coding gene Chr2:127973749-127989014 (-)
C3H/HeJ MGP_C3HHeJ_G0026210
 protein coding gene Chr2:131830959-131844250 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026912
 protein coding gene Chr2:137241237-137254516 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024289
 protein coding gene Chr2:122486337-122500310 (-)
CAST/EiJ MGP_CASTEiJ_G0025671
 protein coding gene Chr2:132082185-132095466 (-)
CBA/J MGP_CBAJ_G0026190
 protein coding gene Chr2:142314425-142327716 (-)
DBA/2J MGP_DBA2J_G0026324
 protein coding gene Chr2:127082034-127095313 (-)
FVB/NJ MGP_FVBNJ_G0026288
 protein coding gene Chr2:125727868-125741161 (-)
LP/J MGP_LPJ_G0026429
 protein coding gene Chr2:133350578-133363869 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026308
 protein coding gene Chr2:146200910-146214188 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026967
 protein coding gene Chr2:131350837-131364128 (-)
PWK/PhJ MGP_PWKPhJ_G0025407
 protein coding gene Chr2:126656023-126669717 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025209
 protein coding gene Chr2:130476379-130489669 (-)
WSB/EiJ MGP_WSBEiJ_G0025745
 protein coding gene Chr2:132278398-132291754 (-)



Homology
more
  • Human Ortholog
    PDYN, prodynorphin
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PDYN, prodynorphin
  • Synonyms
    ADCA, PENKB, SCA23
  • Links
    NCBI Gene ID: 5173
    neXtProt AC: NX_P01213
    UniProt: P01213

  • Chr Location
    20p13; chr20:1978756-1994285 (-)  GRCh38
Human Diseases
more
  • Diseases
    9 with human PDYN associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    30 phenotypes from 4 alleles in 6 genetic backgrounds
    1 phenotype from multigenic genotypes
    112 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit high postnatal mortality, impaired thermoregulation, and loss of white fat. Survivors show ketosis, microvesicular fat accumulation, elevated serum lipids, and behavioral abnormalities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    810
  • Tissues
    61
  • cDNA Data
    7
  • Literature Summary
    27
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000027400 Ensembl Gene Model | MGI Sequence Detail 13280 C57BL/6J ±  kb
    transcript ENSMUST00000028883 Ensembl | MGI Sequence Detail 2386 Not Applicable  
    polypeptide ENSMUSP00000028883 Ensembl | MGI Sequence Detail 248 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 19
      Genomic 3
      cDNA 8
      Primer pair 4
      Other 4

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-13223
    References
    more
    • Summaries
      All 180
      Developmental Gene Expression 27
      Gene Ontology 7
      Phenotypes 112
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:355752 Wietek J, et al., A bistable inhibitory optoGPCR for multiplexed optogenetic control of neural circuits. Nat Methods. 2024 Jul;21(7):1275-1287
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    10/29/2024
    MGI 6.24     		The Jackson Laboratory