Bok MGI Mouse Gene Detail - MGI:1858494 - BCL2-related ovarian killer

Symbol

Bok
Name

BCL2-related ovarian killer
Synonyms

matador, mtd

Feature Type

protein coding gene
IDs

MGI:1858494
NCBI Gene: 51800
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr1:93613382-93623486 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 47.28 cM
Mapping Data

1 experiment

SNPs within 2kb

376 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1858494	protein coding gene	Chr1:93613297-93623492 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016346	protein coding gene	Chr1:95325817-95336007 (+)
A/J	MGP_AJ_G0016327	protein coding gene	Chr1:91911965-91922200 (+)
AKR/J	MGP_AKRJ_G0016288	protein coding gene	Chr1:94620872-94631013 (+)
BALB/cJ	MGP_BALBcJ_G0016283	protein coding gene	Chr1:92089745-92099892 (+)
C3H/HeJ	MGP_C3HHeJ_G0016112	protein coding gene	Chr1:94879201-94890290 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016742	protein coding gene	Chr1:98945134-98956397 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014460	protein coding gene	Chr1:86153635-86163476 (+)
CAST/EiJ	MGP_CASTEiJ_G0015695	protein coding gene	Chr1:94213643-94223703 (+)
CBA/J	MGP_CBAJ_G0016086	protein coding gene	Chr1:102156614-102168938 (+)
DBA/2J	MGP_DBA2J_G0016191	protein coding gene	Chr1:91117904-91128017 (+)
FVB/NJ	MGP_FVBNJ_G0016190	protein coding gene	Chr1:90177965-90188091 (+)
LP/J	MGP_LPJ_G0016262	protein coding gene	Chr1:96503139-96513294 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016215	protein coding gene	Chr1:105245358-105256687 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016781	protein coding gene	Chr1:94646127-94656181 (+)
PWK/PhJ	MGP_PWKPhJ_G0015480	protein coding gene	Chr1:90541332-90553679 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015264	protein coding gene	Chr1:93587393-93598961 (+)
WSB/EiJ	MGP_WSBEiJ_G0015755	protein coding gene	Chr1:94464542-94474583 (+)

Human Ortholog

BOK, BCL2 family apoptosis regulator BOK

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

BOK, BCL2 family apoptosis regulator BOK
Synonyms

BCL2L9, BOKL
Links

HGNC:1087

NCBI Gene ID: 666

neXtProt AC: NX_Q9UMX3

UniProt: Q9UMX3
Chr Location

2q37.3; chr2:241551393-241574131 (+) GRCh38

MGI Vertebrate Homology

Bok stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: BOK
Gene Tree

Bok

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Phenotype Summary

6 phenotypes from 2 alleles in 2 genetic backgrounds
1 phenotype from multigenic genotypes
29 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Chemically induced (other)

1
Endonuclease-mediated

4
Gene trapped

1
Radiation induced

1
Targeted

7
Genomic Mutations

2 involving Bok
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

22 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit minor increase in spleen and thymus weight in female, but not male, mice.

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All GO Annotations

73
GO References

13

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

766
Tissues

42
cDNA Data

11
Literature Summary

7

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA BOK

Xenbase bok

ZFIN boka, bokb

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All Sequences

45
RefSeq

2
UniProt

4
CCDS

CCDS15193.1

Ensembl

ENSMUSG00000026278 (Evidence)
NCBI Gene

51800

			Length	Strain/Species	Flank
genomic	ENSMUSG00000026278	Ensembl Gene Model \| MGI Sequence Detail	10105	C57BL/6J	± kb
transcript	ENSMUST00000201863	Ensembl \| MGI Sequence Detail	883	Not Applicable
polypeptide	ENSMUSP00000144347	Ensembl \| MGI Sequence Detail	213	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000004785 Bcl-2-related ovarian killer protein

(term hierarchy)
InterPro Domains

IPR046371 Bcl-2, Bcl-2 homology region 1-3

IPR026298 Bcl-2 family

IPR002475 Bcl2-like

IPR036834 Bcl-2-like superfamily

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All nucleic 14

cDNA 11

Primer pair 1

Other 2

Microarray probesets 3

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MGI:2138345, MGI:2138464

Summaries

All 62

Developmental Gene Expression 7

Gene Ontology 13

Phenotypes 29
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:353791 Xu L, et al., Context-dependent roles of mitochondrial LONP1 in orchestrating the balance between airway progenitor versus progeny cells. Cell Stem Cell. 2024 Aug 16;

TSS for Bok:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr8188	Chr1:93613190-93613206 (+)	-184 bp
Tssr8189	Chr1:93613296-93613400 (+)	-34 bp
Tssr8190	Chr1:93613405-93613431 (+)	36 bp
Tssr8191	Chr1:93613460-93613529 (+)	113 bp
Tssr8192	Chr1:93613628-93613651 (+)	258 bp
Tssr8193	Chr1:93621442-93621457 (+)	8,068 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24