Fkbpl MGI Mouse Gene Detail - MGI:1932127 - FK506 binding protein-like

Symbol

Fkbpl
Name

FK506 binding protein-like
Synonyms

DIR1, NG7, Ppiase-X, WAF-1/CIP1 stabilizing protein 39, WISp39

Feature Type

protein coding gene
IDs

MGI:1932127
NCBI Gene: 56299
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr17:34863738-34865298 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 18.22 cM
Mapping Data

1 experiment

Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1932127	protein coding gene	Chr17:34863738-34865791 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0023585	protein coding gene	Chr17:34726621-34728181 (+)
A/J	MGP_AJ_G0023547	protein coding gene	Chr17:33542865-33544425 (+)
AKR/J	MGP_AKRJ_G0023512	protein coding gene	Chr17:33962481-33964041 (+)
BALB/cJ	MGP_BALBcJ_G0023551	protein coding gene	Chr17:33691907-33693467 (+)
C3H/HeJ	MGP_C3HHeJ_G0023311	protein coding gene	Chr17:34356446-34358006 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0023991	protein coding gene	Chr17:36052063-36053623 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021470	protein coding gene	Chr17:31432355-31433911 (+)
CAST/EiJ	MGP_CASTEiJ_G0022811	protein coding gene	Chr17:34428586-34430146 (+)
CBA/J	MGP_CBAJ_G0023289	protein coding gene	Chr17:37573049-37574609 (+)
DBA/2J	MGP_DBA2J_G0023417	protein coding gene	Chr17:32833033-32834593 (+)
FVB/NJ	MGP_FVBNJ_G0023384	protein coding gene	Chr17:32737327-32738886 (+)
LP/J	MGP_LPJ_G0023495	protein coding gene	Chr17:34998534-35000094 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023407	protein coding gene	Chr17:36461846-36463406 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024034	protein coding gene	Chr17:34270114-34271669 (+)
PWK/PhJ	MGP_PWKPhJ_G0022559	protein coding gene	Chr17:31762346-31763906 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0022376	protein coding gene	Chr17:32257464-32259018 (+)
WSB/EiJ	MGP_WSBEiJ_G0022872	protein coding gene	Chr17:34364559-34366119 (+)

Human Ortholog

FKBPL, FKBP prolyl isomerase like

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FKBPL, FKBP prolyl isomerase like
Synonyms

DIR1, NG7, WISP39
Links

HGNC:13949

NCBI Gene ID: 63943

neXtProt AC: NX_Q9UIM3

UniProt: Q9UIM3
Chr Location

6p21.32; chr6:32128707-32130288 (-) GRCh38

MGI Vertebrate Homology

Fkbpl stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: FKBPL
Gene Tree

Fkbpl

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Phenotype Summary

11 phenotypes from 2 alleles in 4 genetic backgrounds
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Gene trapped

7
Targeted

2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

41 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous inactivation of this gene leads to complete embryonic lethality. Heterozygotes develop normally but exhibit enhanced angiogenesis in various experimental and tumor disease models.

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All GO Annotations

6
GO References

1

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

759
Tissues

26
cDNA Data

30
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase fkbpl

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All Sequences

34
RefSeq

2
UniProt

2
CCDS

CCDS28654.1

Ensembl

ENSMUSG00000033739 (Evidence)
NCBI Gene

56299

			Length	Strain/Species	Flank
genomic	ENSMUSG00000033739	Ensembl Gene Model \| MGI Sequence Detail	1561	C57BL/6J	± kb
transcript	ENSMUST00000036720	Ensembl \| MGI Sequence Detail	1270	Not Applicable
polypeptide	ENSMUSP00000037273	Ensembl \| MGI Sequence Detail	347	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000007546 FK506-binding protein-like

(term hierarchy)
InterPro Domains

IPR050754 Immunophilin FKBP-type domain-containing protein

IPR011990 Tetratricopeptide-like helical domain superfamily

IPR019734 Tetratricopeptide repeat

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All nucleic 32

Genomic 1

cDNA 30

Primer pair 1

Microarray probesets 2

Summaries

All 28

Developmental Gene Expression 2

Gene Ontology 1

Phenotypes 10
Earliest

J:63109 Yung Yu C, et al., The human and mouse MHC class III region: a parade of 21 genes at the centromeric segment. Immunol Today. 2000 Jul;21(7):320-8
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Fkbpl:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr144097	Chr17:34862912-34862921 (+)	-821 bp
Tssr144098	Chr17:34862929-34862933 (+)	-807 bp
Tssr144099	Chr17:34862936-34862945 (+)	-797 bp
Tssr144100	Chr17:34863755-34863771 (+)	25 bp
Tssr144101	Chr17:34863779-34863844 (+)	74 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24