Clk4 MGI Mouse Gene Detail - MGI:1098551

Symbol

Clk4
Name

CDC like kinase 4

Feature Type

protein coding gene
IDs

MGI:1098551
NCBI Gene: 12750
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr11:51153941-51172597 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 31.02 cM
Mapping Data

3 experiments

SNPs within 2kb

393 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1098551	protein coding gene	Chr11:51152557-51172597 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018266	protein coding gene	Chr11:50483075-50503319 (+)
A/J	MGP_AJ_G0018235	protein coding gene	Chr11:48592615-48612174 (+)
AKR/J	MGP_AKRJ_G0018205	protein coding gene	Chr11:50118415-50138111 (+)
BALB/cJ	MGP_BALBcJ_G0018206	protein coding gene	Chr11:48892818-48913784 (+)
C3H/HeJ	MGP_C3HHeJ_G0018017	protein coding gene	Chr11:50152990-50177008 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018656	protein coding gene	Chr11:52023091-52042394 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016308	protein coding gene	Chr11:46167389-46187219 (+)
CAST/EiJ	MGP_CASTEiJ_G0017581	protein coding gene	Chr11:50139618-50158977 (+)
CBA/J	MGP_CBAJ_G0017992	protein coding gene	Chr11:54462260-54488311 (+)
DBA/2J	MGP_DBA2J_G0018099	protein coding gene	Chr11:48307112-48327276 (+)
FVB/NJ	MGP_FVBNJ_G0018094	protein coding gene	Chr11:48003484-48023018 (+)
LP/J	MGP_LPJ_G0018175	protein coding gene	Chr11:50912100-50935484 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018117	protein coding gene	Chr11:55876084-55896474 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018699	protein coding gene	Chr11:50211570-50230444 (+)
PWK/PhJ	MGP_PWKPhJ_G0017357	protein coding gene	Chr11:48812776-48832719 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017152	protein coding gene	Chr11:49942496-49961795 (+)
WSB/EiJ	MGP_WSBEiJ_G0017629	protein coding gene	Chr11:49861084-49880311 (+)

Human Ortholog

CLK4, CDC like kinase 4

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CLK4, CDC like kinase 4
Links

HGNC:13659

NCBI Gene ID: 57396

neXtProt AC: NX_Q9HAZ1

UniProt: Q9HAZ1
Chr Location

5q35.3; chr5:178602664-178630615 (-) GRCh38

MGI Vertebrate Homology

Clk4 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: CLK4
Gene Tree

Clk4

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Phenotype Summary

10 phenotypes from 1 allele in 1 genetic background
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

24
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

16
Targeted

4
Genomic Mutations

1 involving Clk4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

37 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a conditional allele activated in cardiomyocytes exhibit congestive heart failure, enlarged hearts and lungs, cardiac interstitial fibrosis, and abnormal cardiomyocyte sarcomere morphology.

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All GO Annotations

15
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

722
Tissues

14
cDNA Data

98
Literature Summary

3

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN clk4a, clk4b

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All Sequences

93
RefSeq

32
UniProt

6
CCDS

CCDS24651.1, CCDS78942.1

Ensembl

ENSMUSG00000020385 (Evidence)
NCBI Gene

12750

			Length	Strain/Species	Flank
genomic	12750	NCBI Gene Model \| MGI Sequence Detail	18657	C57BL/6J	± kb
transcript	NM_001430880	RefSeq \| MGI Sequence Detail	3350	C57BL/6
polypeptide	O35493	UniProt \| EBI \| MGI Sequence Detail	481	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000005587 dual specificity protein kinase CLK4

(term hierarchy)
EC

2.7.12.1
InterPro Domains

IPR051175 Dual specificity CLK kinases

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR008271 Serine/threonine-protein kinase, active site

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All nucleic 101

cDNA 99

Primer pair 2

Microarray probesets 5

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MGI:2144335, MGI:2144675

Summaries

All 47

Developmental Gene Expression 3

Gene Ontology 8

Phenotypes 14
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:327369 Huang J, et al., CDC-like kinase 4 deficiency contributes to pathological cardiac hypertrophy by modulating NEXN phosphorylation. Nat Commun. 2022 Jul 30;13(1):4433

TSS for Clk4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr101273	Chr11:51152546-51152558 (+)	-1,389 bp
Tssr101274	Chr11:51153376-51153403 (+)	-551 bp
Tssr101275	Chr11:51153772-51153781 (+)	-164 bp
Tssr101276	Chr11:51153948-51154024 (+)	45 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/05/2024 MGI 6.24