Ift81 MGI Mouse Gene Detail - MGI:1098597 - intraflagellar transport 81

Symbol

Ift81
Name

intraflagellar transport 81
Synonyms

Cdv1, CDV-1R

Feature Type

protein coding gene
IDs

MGI:1098597
NCBI Gene: 12589
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr5:122688267-122752581 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 62.44 cM
Mapping Data

3 experiments

SNPs within 2kb

1382 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1098597	protein coding gene	Chr5:122678328-122752614 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0030054	protein coding gene	Chr5:126186333-126255431 (-)
A/J	MGP_AJ_G0030019	protein coding gene	Chr5:120960410-121025019 (-)
AKR/J	MGP_AKRJ_G0029955	protein coding gene	Chr5:124854656-124919416 (-)
BALB/cJ	MGP_BALBcJ_G0030030	protein coding gene	Chr5:122307558-122372986 (-)
C3H/HeJ	MGP_C3HHeJ_G0029747	protein coding gene	Chr5:125487064-125553275 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0030483	protein coding gene	Chr5:131038285-131124605 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027709	protein coding gene	Chr5:115567504-115631379 (-)
CAST/EiJ	MGP_CASTEiJ_G0029156	protein coding gene	Chr5:124569518-124641220 (-)
CBA/J	MGP_CBAJ_G0029717	protein coding gene	Chr5:136176711-136248808 (-)
DBA/2J	MGP_DBA2J_G0029867	protein coding gene	Chr5:121017048-121081732 (-)
FVB/NJ	MGP_FVBNJ_G0029823	protein coding gene	Chr5:120012253-120076086 (-)
LP/J	MGP_LPJ_G0029956	protein coding gene	Chr5:126732720-126796478 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029854	protein coding gene	Chr5:139914102-139983082 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030524	protein coding gene	Chr5:124454882-124524906 (-)
PWK/PhJ	MGP_PWKPhJ_G0028870	protein coding gene	Chr5:119799547-119865187 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0028707	protein coding gene	Chr5:122152732-122225560 (-)
WSB/EiJ	MGP_WSBEiJ_G0029231	protein coding gene	Chr5:125117276-125183651 (-)

Human Ortholog

IFT81, intraflagellar transport 81

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

IFT81, intraflagellar transport 81
Synonyms

CDV-1, CDV1, CDV-1R, CDV1R, DV1, SRTD19
Links

HGNC:14313

NCBI Gene ID: 28981

neXtProt AC: NX_Q8WYA0

UniProt: Q8WYA0
Chr Location

12q24.11; chr12:110124335-110218793 (+) GRCh38

MGI Vertebrate Homology

Ift81 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: IFT81
Gene Tree

Ift81

Diseases

1 with human IFT81 associations

				Human Disease	Mouse Models
				short-rib thoracic dysplasia 19 with or without polydactyly IDs short-rib thoracic dysplasia 19 with or without polydactyly DOID:0080295 OMIM:617895

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

29 phenotypes from 2 alleles in 2 genetic backgrounds
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Chemically induced (other)

1
Gene trapped

4
Radiation induced

1
Targeted

6
Genomic Mutations

2 involving Ift81
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

34 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

31
GO References

14

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

46
Literature Summary

3

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ift81

ZFIN ift81

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All Sequences

75
RefSeq

18
UniProt

6
CCDS

CCDS19650.1

Ensembl

ENSMUSG00000029469 (Evidence)
NCBI Gene

12589

			Length	Strain/Species	Flank
genomic	ENSMUSG00000029469	Ensembl Gene Model \| MGI Sequence Detail	64315	C57BL/6J	± kb
transcript	ENSMUST00000031426	Ensembl \| MGI Sequence Detail	2950	Not Applicable
polypeptide	ENSMUSP00000031426	Ensembl \| MGI Sequence Detail	676	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000008939 intraflagellar transport protein 81

(term hierarchy)
InterPro Domains

IPR041146 IFT81, calponin homology domain

IPR043016 IFT81, N-terminal domain superfamily

IPR029600 Intraflagellar transport protein 81
GlyGen

O35594 3 sites, 2 N-linked glycans (3 sites)

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All nucleic 46

cDNA 46

Microarray probesets 6

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MGI:2141144

Summaries

All 53

Developmental Gene Expression 3

Gene Ontology 14

Phenotypes 16
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Ift81:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr53144	Chr5:122752549-122752607 (-)	3 bp
Tssr53143	Chr5:122698898-122698909 (-)	53,677 bp
Tssr53142	Chr5:122698868-122698875 (-)	53,709 bp
Tssr53141	Chr5:122698831-122698840 (-)	53,745 bp
Tssr53140	Chr5:122698801-122698818 (-)	53,771 bp
Tssr53139	Chr5:122698766-122698779 (-)	53,808 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/05/2024 MGI 6.24