Anxa8 MGI Mouse Gene Detail - MGI:1201374

Symbol

Anxa8
Name

annexin A8
Synonyms

Anx8

Feature Type

protein coding gene
IDs

MGI:1201374
NCBI Gene: 11752
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr14:33807938-33822528 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 20.80 cM
Mapping Data

3 experiments

SNPs within 2kb

620 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1201374	protein coding gene	Chr14:33807936-33822528 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021166	protein coding gene	Chr14:27420918-27435428 (+)
A/J	MGP_AJ_G0021114	protein coding gene	Chr14:26360832-26375422 (+)
AKR/J	MGP_AKRJ_G0021091	protein coding gene	Chr14:27534140-27548730 (+)
BALB/cJ	MGP_BALBcJ_G0021118	protein coding gene	Chr14:26545681-26560283 (+)
C3H/HeJ	MGP_C3HHeJ_G0020901	protein coding gene	Chr14:27451652-27466183 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0021550	protein coding gene	Chr14:28480238-28494816 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019112	protein coding gene	Chr14:26396713-26411146 (+)
CAST/EiJ	MGP_CASTEiJ_G0020426	protein coding gene	Chr14:27270846-27285359 (+)
CBA/J	MGP_CBAJ_G0020868	protein coding gene	Chr14:29503356-29517886 (+)
DBA/2J	MGP_DBA2J_G0020990	protein coding gene	Chr14:26394577-26409008 (+)
FVB/NJ	MGP_FVBNJ_G0020974	protein coding gene	Chr14:26360517-26375120 (+)
LP/J	MGP_LPJ_G0021059	protein coding gene	Chr14:27755025-27769569 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021000	protein coding gene	Chr14:28660678-28675264 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021583	protein coding gene	Chr14:27366702-27381414 (+)
PWK/PhJ	MGP_PWKPhJ_G0020174	protein coding gene	Chr14:25888819-25903255 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0019998	protein coding gene	Chr14:26966286-26980278 (+)
WSB/EiJ	MGP_WSBEiJ_G0020481	protein coding gene	Chr14:27421473-27436058 (+)

Human Ortholog

ANXA8, annexin A8

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ANXA8, annexin A8
Synonyms

ANX8, CH17-360D5.2
Links

HGNC:546

NCBI Gene ID: 653145

neXtProt AC: NX_P13928

UniProt: P13928
Chr Location

10q11.22

MGI Vertebrate Homology

Anxa8 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: ANXA8
Gene Tree

Anxa8

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
5 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

2
Endonuclease-mediated

1
Targeted

1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

19 strains or lines available

Mice homozygous for a floxed allele activated in all cells exhibit impaired leukocyte rolling flux and adhesion.

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All GO Annotations

23
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

877
Tissues

96
cDNA Data

52
Literature Summary

5

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA ANXA8L1

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All Sequences

36
RefSeq

4
UniProt

2
CCDS

CCDS26932.1, CCDS70565.1

Ensembl

ENSMUSG00000021950 (Evidence)
NCBI Gene

11752

			Length	Strain/Species	Flank
genomic	ENSMUSG00000021950	Ensembl Gene Model \| MGI Sequence Detail	14591	C57BL/6J	± kb
transcript	ENSMUST00000022519	Ensembl \| MGI Sequence Detail	1880	Not Applicable
polypeptide	ENSMUSP00000022519	Ensembl \| MGI Sequence Detail	327	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000004081 annexin A8

(term hierarchy)
InterPro Domains

IPR001464 Annexin

IPR009115 Annexin A8

IPR018502 Annexin repeat

IPR018252 Annexin repeat, conserved site

IPR037104 Annexin superfamily

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All nucleic 56

cDNA 52

Primer pair 3

Other 1

Microarray probesets 4

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MGI:2145662

Summaries

All 35

Developmental Gene Expression 5

Gene Ontology 4

Phenotypes 5
Earliest

J:45414 Fernandez MP, et al., The genetic origin of mouse annexin VIII. Mamm Genome. 1998 Jan;9(1):8-14
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Anxa8:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr125063	Chr14:33807935-33807961 (+)	10 bp
Tssr125064	Chr14:33807965-33807983 (+)	36 bp
Tssr125065	Chr14:33813764-33813771 (+)	5,830 bp
Tssr125066	Chr14:33814487-33814489 (+)	6,550 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 10/29/2024 MGI 6.24