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Ap1b1 Gene Detail
Summary
  • Symbol
    Ap1b1
  • Name
    adaptor protein complex AP-1, beta 1 subunit
  • Synonyms
    Adtb1, b2b1660Clo, beta-prime adaptin
  • Feature Type
    protein coding gene
  • IDs
    MGI:1096368
    NCBI Gene: 11764
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:4936824-4992791 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 3.15 cM, cytoband A2
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1269 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1096368
 protein coding gene Chr11:4897320-4992791 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017993
 protein coding gene Chr11:2001393-2062164 (+)
A/J MGP_AJ_G0017966
 protein coding gene Chr11:1943332-2000072 (+)
AKR/J MGP_AKRJ_G0017930
 protein coding gene Chr11:2036809-2094625 (+)
BALB/cJ MGP_BALBcJ_G0017934
 protein coding gene Chr11:1916703-1972856 (+)
C3H/HeJ MGP_C3HHeJ_G0017747
 protein coding gene Chr11:1923657-1982373 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018386
 protein coding gene Chr11:2067551-2128095 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016044
 protein coding gene Chr11:1839730-1893671 (+)
CAST/EiJ MGP_CASTEiJ_G0017309
 protein coding gene Chr11:1900972-1961612 (+)
CBA/J MGP_CBAJ_G0017722
 protein coding gene Chr11:2352970-2419761 (+)
DBA/2J MGP_DBA2J_G0017832
 protein coding gene Chr11:1844682-1901465 (+)
FVB/NJ MGP_FVBNJ_G0017824
 protein coding gene Chr11:1884641-1939336 (+)
LP/J MGP_LPJ_G0017903
 protein coding gene Chr11:2081074-2138727 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017850
 protein coding gene Chr11:1999129-2056907 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018426
 protein coding gene Chr11:2037995-2095561 (+)
PWK/PhJ MGP_PWKPhJ_G0017089
 protein coding gene Chr11:1860099-1917543 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016886
 protein coding gene Chr11:2027069-2083258 (+)
WSB/EiJ MGP_WSBEiJ_G0017363
 protein coding gene Chr11:1910830-1967370 (+)



Homology
more
  • Human Ortholog
    AP1B1, adaptor related protein complex 1 subunit beta 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AP1B1, adaptor related protein complex 1 subunit beta 1
  • Synonyms
    ADTB1, AP105A, BAM22, CLAPB2, KIDAR
  • Links
    NCBI Gene ID: 162
    neXtProt AC: NX_Q10567
    UniProt: Q10567

  • Chr Location
    22q12.2; chr22:29327680-29388583 (-)  GRCh38
Human Diseases
more
  • Diseases
    3 with Ap1b1 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
IDs
 View 1 model
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 1 allele in 1 genetic background
    20 images
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    708
  • Tissues
    2
  • cDNA Data
    15
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000009090 Ensembl Gene Model | MGI Sequence Detail 55968 C57BL/6J ±  kb
    transcript ENSMUST00000009234 Ensembl | MGI Sequence Detail 4085 Not Applicable  
    polypeptide ENSMUSP00000009234 Ensembl | MGI Sequence Detail 943 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • Protein Ontology
      PR:000004090 AP-1 complex subunit beta-1
      (term hierarchy)
    • InterPro Domains
      IPR016342 AP-1/2/4 complex subunit beta
      IPR026739 AP complex subunit beta
      IPR000225 Armadillo
      IPR011989 Armadillo-like helical
      IPR016024 Armadillo-type fold
      IPR015151 Beta-adaptin appendage, C-terminal subdomain
      IPR008152 Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain
      IPR013041 Clathrin adaptor, appendage, Ig-like subdomain superfamily
      IPR013037 Clathrin adaptor, beta-adaptin, appendage, Ig-like subdomain
      IPR002553 Clathrin/coatomer adaptor, adaptin-like, N-terminal
      IPR009028 Coatomer/calthrin adaptor appendage, C-terminal subdomain
      IPR032682 Condensin complex subunit 1, C-terminal
      IPR012295 TBP domain superfamily
    • GlyGen
      O35643 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 21
      Genomic 5
      cDNA 15
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:5433318
    References
    more
    • Summaries
      All 56
      Developmental Gene Expression 3
      Diseases 1
      Gene Ontology 15
      Phenotypes 16
    • Earliest
      J:42384 Guilbaud C, et al., Characterization of the mouse beta-prime adaptin gene; cDNA sequence, genomic structure, and chromosomal localization. Mamm Genome. 1997 Sep;8(9):651-6
    • Latest
      J:346429 Ninkina N, et al., beta-synuclein potentiates synaptic vesicle dopamine uptake and rescues dopaminergic neurons from MPTP-induced death in the absence of other synucleins. J Biol Chem. 2021 Nov 2;297(6):101375
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory