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Capn6 Gene Detail
Summary
  • Symbol
    Capn6
  • Name
    calpain 6
  • Feature Type
    protein coding gene
  • IDs
    MGI:1100850
    NCBI Gene: 12338
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:142585232-142610408 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 64.83 cM, cytoband F2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    518 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1100850
 protein coding gene ChrX:142585227-142610410 (-)
129S1/SvImJ MGP_129S1SvImJ_G0036156
 protein coding gene ChrX:141366625-141392165 (-)
A/J MGP_AJ_G0036133
 protein coding gene ChrX:140692073-140717956 (-)
AKR/J MGP_AKRJ_G0036059
 protein coding gene ChrX:145249696-145277391 (-)
BALB/cJ MGP_BALBcJ_G0036124
 protein coding gene ChrX:138925937-138952870 (-)
C3H/HeJ MGP_C3HHeJ_G0035832
 protein coding gene ChrX:141440535-141466319 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036647
 protein coding gene ChrX:145312772-145337917 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033471
 protein coding gene ChrX:132220046-132245190 (-)
CAST/EiJ MGP_CASTEiJ_G0035123
 protein coding gene ChrX:122137197-122164732 (-)
CBA/J MGP_CBAJ_G0035809
 protein coding gene ChrX:149882215-149907263 (-)
DBA/2J MGP_DBA2J_G0035967
 protein coding gene ChrX:139788428-139813872 (-)
FVB/NJ MGP_FVBNJ_G0035901
 protein coding gene ChrX:138983610-139008820 (-)
LP/J MGP_LPJ_G0036058
 protein coding gene ChrX:142308820-142336359 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035937
 protein coding gene ChrX:157593261-157619281 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036684
 protein coding gene ChrX:140661952-140687946 (-)
PWK/PhJ MGP_PWKPhJ_G0034817
 protein coding gene ChrX:118932117-118957350 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034642
 protein coding gene ChrX:122681978-122706951 (-)
WSB/EiJ MGP_WSBEiJ_G0035258
 protein coding gene ChrX:139022921-139048116 (-)



Homology
more
  • Human Ortholog
    CAPN6, calpain 6
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CAPN6, calpain 6
  • Synonyms
    CalpM, CANPX, CAPNX, DJ914P14.1
  • Links
    NCBI Gene ID: 827
    neXtProt AC: NX_Q9Y6Q1
    UniProt: Q9Y6Q1

  • Chr Location
    Xq23; chrX:111245099-111270483 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    2 images
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Female mice homozygous for a knock-out allele display advanced skeletal muscle development during embryogenesis and advanced skeletal muscle regeneration after cardiotoxin-induced degeneration. Male hemizygotes exhibit increased differentiation of primary cultured skeletal muscle cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    771
  • Tissues
    47
  • cDNA Data
    85
  • Literature Summary
    17
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12338 NCBI Gene Model | MGI Sequence Detail 25177 C57BL/6J ±  kb
    transcript NM_007603 RefSeq | MGI Sequence Detail 3579 C57BL/6  
    polypeptide O35646 UniProt | EBI | MGI Sequence Detail 641 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 89
      Genomic 1
      cDNA 85
      Primer pair 2
      Other 1

      Microarray probesets 6
    References
    more
    • Summaries
      All 47
      Developmental Gene Expression 17
      Gene Ontology 7
      Phenotypes 6
    • Earliest
      J:43496 Dear N, et al., A new subfamily of vertebrate calpains lacking a calmodulin-like domain: implications for calpain regulation and evolution. Genomics. 1997 Oct 1;45(1):175-84
    • Latest
      J:312465 Yin Y, et al., Signaling through retinoic acid receptors is essential for mammalian uterine receptivity and decidualization. JCI Insight. 2021 Sep 8;6(17)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory