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Mgll Gene Detail
Summary
  • Symbol
    Mgll
  • Name
    monoglyceride lipase
  • Synonyms
    Magl
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346042
    NCBI Gene: 23945
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:88701397-88805342 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 39.51 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2477 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1346042
 protein coding gene Chr6:88701394-88805342 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031013
 protein coding gene Chr6:90126328-90242273 (+)
A/J MGP_AJ_G0030979
 protein coding gene Chr6:86664915-86773533 (+)
AKR/J MGP_AKRJ_G0030910
 protein coding gene Chr6:89142623-89250935 (+)
BALB/cJ MGP_BALBcJ_G0030992
 protein coding gene Chr6:86655789-86761176 (+)
C3H/HeJ MGP_C3HHeJ_G0030718
 protein coding gene Chr6:95191681-95300319 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031449
 protein coding gene Chr6:92550290-92659173 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028631
 protein coding gene Chr6:84820284-84925760 (+)
CAST/EiJ MGP_CASTEiJ_G0030101
 protein coding gene Chr6:89260620-89369791 (+)
CBA/J MGP_CBAJ_G0030676
 protein coding gene Chr6:96097918-96202012 (+)
DBA/2J MGP_DBA2J_G0030832
 protein coding gene Chr6:85944736-86052929 (+)
FVB/NJ MGP_FVBNJ_G0030785
 protein coding gene Chr6:85139122-85246500 (+)
LP/J MGP_LPJ_G0030909
 protein coding gene Chr6:90156477-90266440 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030818
 protein coding gene Chr6:100203552-100308686 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031476
 protein coding gene Chr6:89009793-89115649 (+)
PWK/PhJ MGP_PWKPhJ_G0029816
 protein coding gene Chr6:84929255-85035335 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029644
 protein coding gene Chr6:87818554-87922943 (+)
WSB/EiJ MGP_WSBEiJ_G0030182
 protein coding gene Chr6:89463632-89569351 (+)



Homology
more
  • Human Ortholog
    MGLL, monoglyceride lipase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MGLL, monoglyceride lipase
  • Synonyms
    HU-K5, HUK5, MAGL, MGL
  • Links
    NCBI Gene ID: 11343
    neXtProt AC: NX_Q99685
    UniProt: Q99685

  • Chr Location
    3q21.3; chr3:127689062-128052190 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    25 phenotypes from 3 alleles in 3 genetic backgrounds
    47 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trapped allele exhibit hypoalgesia, increased body temperature, and decreased fatty acid levels. Mice homozygous for a targeted allele exhibit impaired lipolysis and improved glucose homeostasis on a high-fat diet.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    35
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    927
  • Tissues
    115
  • cDNA Data
    140
  • Literature Summary
    15
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 23945 NCBI Gene Model | MGI Sequence Detail 103946 C57BL/6J ±  kb
    transcript NM_001166251 RefSeq | MGI Sequence Detail 3992 C57BL/6  
    polypeptide O35678 UniProt | EBI | MGI Sequence Detail 303 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 142
      cDNA 140
      Primer pair 2

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:1889369
    References
    more
    • Summaries
      All 102
      Developmental Gene Expression 15
      Gene Ontology 12
      Phenotypes 47
    • Earliest
      J:51746 Karlsson M, et al., cDNA cloning, tissue distribution, and identification of the catalytic triad of monoglyceride lipase. Evolutionary relationship to esterases, lysophospholipases, and haloperoxidases. J Biol Chem. 1997 Oct 24;272(43):27218-23
    • Latest
      J:359054 Morales-Soto W, et al., Endocannabinoids regulate enteric neuron-glia networks and visceral hypersensitivity following inflammation through a glial-dependent mechanism. Glia. 2024 Nov;72(11):2095-2114
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory