Enc1 MGI Mouse Gene Detail - MGI:109610 - ectodermal-neural cortex 1

Symbol

Enc1
Name

ectodermal-neural cortex 1
Synonyms

Nrpb, PIG10

Feature Type

protein coding gene
IDs

MGI:109610
NCBI Gene: 13803
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr13:97377613-97389542 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 50.66 cM, cytoband D1
Mapping Data

2 experiments

SNPs within 2kb

385 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_109610	protein coding gene	Chr13:97377613-97389548 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020860	protein coding gene	Chr13:98847078-98860281 (+)
A/J	MGP_AJ_G0020814	protein coding gene	Chr13:95103787-95115730 (+)
AKR/J	MGP_AKRJ_G0020788	protein coding gene	Chr13:98007077-98019021 (+)
BALB/cJ	MGP_BALBcJ_G0020811	protein coding gene	Chr13:95788222-95800146 (+)
C3H/HeJ	MGP_C3HHeJ_G0020603	protein coding gene	Chr13:97726321-97739247 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0021246	protein coding gene	Chr13:101822366-101834386 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018816	protein coding gene	Chr13:90867418-90879295 (+)
CAST/EiJ	MGP_CASTEiJ_G0020122	protein coding gene	Chr13:97049602-97056790 (+)
CBA/J	MGP_CBAJ_G0020563	protein coding gene	Chr13:105904025-105918270 (+)
DBA/2J	MGP_DBA2J_G0020688	protein coding gene	Chr13:94857981-94869899 (+)
FVB/NJ	MGP_FVBNJ_G0020669	protein coding gene	Chr13:93625011-93637001 (+)
LP/J	MGP_LPJ_G0020763	protein coding gene	Chr13:98952716-98964663 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020697	protein coding gene	Chr13:106228254-106241403 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021287	protein coding gene	Chr13:97425409-97438923 (+)
PWK/PhJ	MGP_PWKPhJ_G0019874	protein coding gene	Chr13:93650179-93657432 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0019698	protein coding gene	Chr13:93709988-93719951 (+)
WSB/EiJ	MGP_WSBEiJ_G0020179	protein coding gene	Chr13:97882163-97894082 (+)

Human Ortholog

ENC1, ectodermal-neural cortex 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ENC1, ectodermal-neural cortex 1
Synonyms

CCL28, ENC-1, KLHL35, KLHL37, NRPB, PIG10, TP53I10
Links

HGNC:3345

NCBI Gene ID: 8507

neXtProt AC: NX_O14682

UniProt: O14682
Chr Location

5q13.3; chr5:74627406-74641424 (-) GRCh38

MGI Vertebrate Homology

Enc1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ENC1
Protein SuperFamily

Kelch-like_protein_gigaxonin
Gene Tree

Enc1

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Phenotype Summary

6 phenotypes from 1 allele in 1 genetic background
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

24
Endonuclease-mediated

1
Gene trapped

22
Targeted

1
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

23 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

29
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

980
Tissues

190
cDNA Data

116
Literature Summary

23

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

GEISHA ENC1

Xenbase enc1, enc1.2

ZFIN enc1

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All Sequences

44
RefSeq

8
UniProt

2
CCDS

CCDS26710.1

Ensembl

ENSMUSG00000041773 (Evidence)
NCBI Gene

13803

			Length	Strain/Species	Flank
genomic	ENSMUSG00000041773	Ensembl Gene Model \| MGI Sequence Detail	11930	C57BL/6J	± kb
transcript	ENSMUST00000041623	Ensembl \| MGI Sequence Detail	4737	Not Applicable
polypeptide	ENSMUSP00000038783	Ensembl \| MGI Sequence Detail	589	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000007074 ectoderm-neural cortex protein 1

(term hierarchy)
InterPro Domains

IPR011705 BTB/Kelch-associated

IPR017096 BTB-kelch protein

IPR000210 BTB/POZ domain

IPR047097 Ectoderm-neural cortex protein 1, BACK domain

IPR030562 Ectoderm-neural cortex protein 1, BTB/POZ domain

IPR006652 Kelch repeat type 1

IPR015915 Kelch-type beta propeller

IPR011333 SKP1/BTB/POZ domain superfamily

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All nucleic 125

Genomic 1

cDNA 116

Primer pair 4

Other 4

Microarray probesets 5

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MGD-MRK-39609, MGI:1278341

Summaries

All 61

Developmental Gene Expression 23

Gene Ontology 7

Phenotypes 11
Earliest

J:39574 Hernandez MC, et al., ENC-1: a novel mammalian kelch-related gene specifically expressed in the nervous system encodes an actin-binding protein. J Neurosci. 1997 May 1;17(9):3038-51
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Enc1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr120764	Chr13:97376955-97376973 (+)	-649 bp
Tssr120765	Chr13:97377604-97377624 (+)	1 bp
Tssr120766	Chr13:97377630-97377637 (+)	21 bp
Tssr120767	Chr13:97377722-97377740 (+)	118 bp
Tssr120768	Chr13:97377760-97377776 (+)	155 bp
Tssr120769	Chr13:97378538-97378585 (+)	949 bp
Tssr120770	Chr13:97380448-97380484 (+)	2,853 bp
Tssr120771	Chr13:97380566-97380573 (+)	2,957 bp
Tssr120772	Chr13:97382483-97382495 (+)	4,876 bp
Tssr120773	Chr13:97387228-97387230 (+)	9,616 bp
Tssr120774	Chr13:97387872-97387878 (+)	10,262 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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