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Timm44 Gene Detail
Summary
  • Symbol
    Timm44
  • Name
    translocase of inner mitochondrial membrane 44
  • Synonyms
    0710005E20Rik, D8Ertd118e, Mimt44, Tim44
  • Feature Type
    protein coding gene
  • IDs
    MGI:1343262
    NCBI Gene: 21856
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:4309731-4325905 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 1.99 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    494 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1343262
 protein coding gene Chr8:4309731-4325913 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033332
 protein coding gene Chr8:1245127-1261260 (-)
A/J MGP_AJ_G0033313
 protein coding gene Chr8:1194416-1210533 (-)
AKR/J MGP_AKRJ_G0033244
 protein coding gene Chr8:1229619-1247633 (-)
BALB/cJ MGP_BALBcJ_G0033313
 protein coding gene Chr8:1247507-1263984 (-)
C3H/HeJ MGP_C3HHeJ_G0033027
 protein coding gene Chr8:1239481-1256520 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033825
 protein coding gene Chr8:1284361-1300514 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030797
 protein coding gene Chr8:1069470-1086076 (-)
CAST/EiJ MGP_CASTEiJ_G0032351
 protein coding gene Chr8:1123281-1139490 (-)
CBA/J MGP_CBAJ_G0033000
 protein coding gene Chr8:1323645-1339885 (-)
DBA/2J MGP_DBA2J_G0033154
 protein coding gene Chr8:1154724-1170877 (-)
FVB/NJ MGP_FVBNJ_G0033101
 protein coding gene Chr8:1194010-1210973 (-)
LP/J MGP_LPJ_G0033248
 protein coding gene Chr8:1165252-1181502 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033136
 protein coding gene Chr8:1298889-1317271 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033842
 protein coding gene Chr8:1213255-1229617 (-)
PWK/PhJ MGP_PWKPhJ_G0032062
 protein coding gene Chr8:1119447-1135875 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031905
 protein coding gene Chr8:1134517-1151456 (-)
WSB/EiJ MGP_WSBEiJ_G0032465
 protein coding gene Chr8:1192798-1210149 (-)



Homology
more
  • Human Ortholog
    TIMM44, translocase of inner mitochondrial membrane 44
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TIMM44, translocase of inner mitochondrial membrane 44
  • Synonyms
    TIM44
  • Links
    NCBI Gene ID: 10469
    neXtProt AC: NX_O43615
    UniProt: O43615

  • Chr Location
    19p13.2; chr19:7926718-7943667 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    712
  • Tissues
    3
  • cDNA Data
    118
  • Literature Summary
    5
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 21856 NCBI Gene Model | MGI Sequence Detail 16175 C57BL/6J ±  kb
transcript NM_011592 RefSeq | MGI Sequence Detail 1798 ZRU/MplStud  
polypeptide O35857 UniProt | EBI | MGI Sequence Detail 452 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000016348 mitochondrial import inner membrane translocase subunit TIM44
    (term hierarchy)
  • InterPro Domains
    IPR017303 Mitochondrial import inner membrane translocase subunit Tim44
    IPR032710 NTF2-like domain superfamily
    IPR039544 Tim44-like
    IPR007379 Tim44-like domain
  • GlyGen
    O35857 1 site, 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 119
    cDNA 118
    Primer pair 1

    Microarray probesets 5
Other
Accession IDs
less
MGI:1098601, MGI:1196619, MGI:1923518
References
more
  • Summaries
    All 46
    Developmental Gene Expression 5
    Gene Ontology 10
    Phenotypes 6
  • Earliest
    J:45317 Wada J, et al., Characterization of mammalian translocase of inner mitochondrial membrane (Tim44) isolated from diabetic newborn mouse kidney. Proc Natl Acad Sci U S A. 1998 Jan 6;95(1):144-9
  • Latest
    J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory