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Ascl2 Gene Detail
Summary
  • Symbol
    Ascl2
  • Name
    achaete-scute family bHLH transcription factor 2
  • Synonyms
    2410083I15Rik, bHLHa45, Mash2
  • Feature Type
    protein coding gene
  • IDs
    MGI:96920
    NCBI Gene: 17173
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:142520566-142523001 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 88.08 cM
  • Mapping Data
    19 experiments
Strain
Comparison
more
  • SNPs within 2kb
    92 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96920
 protein coding gene Chr7:142520559-142523001 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033266
 protein coding gene Chr7:148245400-148247842 (-)
A/J MGP_AJ_G0033249
 protein coding gene Chr7:143946642-143949084 (-)
AKR/J MGP_AKRJ_G0033180
 protein coding gene Chr7:147992823-147995265 (-)
BALB/cJ MGP_BALBcJ_G0033249
 protein coding gene Chr7:143722775-143725217 (-)
C3H/HeJ MGP_C3HHeJ_G0032965
 protein coding gene Chr7:147761167-147763609 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033759
 protein coding gene Chr7:153610334-153612776 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030732
 protein coding gene Chr7:145159518-145161950 (-)
CAST/EiJ MGP_CASTEiJ_G0032287
 protein coding gene Chr7:140056958-140059407 (-)
CBA/J MGP_CBAJ_G0032936
 protein coding gene Chr7:158870393-158872835 (-)
DBA/2J MGP_DBA2J_G0033090
 protein coding gene Chr7:141922365-141924807 (-)
FVB/NJ MGP_FVBNJ_G0033038
 protein coding gene Chr7:141844041-141846483 (-)
LP/J MGP_LPJ_G0033182
 protein coding gene Chr7:149761156-149763598 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033072
 protein coding gene Chr7:159454841-159457283 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033779
 protein coding gene Chr7:146955494-146957936 (-)
PWK/PhJ MGP_PWKPhJ_G0031996
 protein coding gene Chr7:135223930-135226371 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031842
 protein coding gene Chr7:133760889-133763331 (-)
WSB/EiJ MGP_WSBEiJ_G0032399
 protein coding gene Chr7:147961245-147963687 (-)



Homology
more
  • Human Ortholog
    ASCL2, achaete-scute family bHLH transcription factor 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ASCL2, achaete-scute family bHLH transcription factor 2
  • Synonyms
    ASH2, bHLHa45, HASH2, MASH2
  • Links
    NCBI Gene ID: 430
    neXtProt AC: NX_Q99929
    UniProt: Q99929

  • Chr Location
    11p15.5; chr11:2268498-2270588 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 5 alleles in 6 genetic backgrounds
    2 phenotypes from multigenic genotypes
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele or heterozygous for a maternally inherited allele exhibit embryonic lethality during organogenesis associated with abnormal embryogenesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    55
  • GO References
    18
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1354
  • Tissues
    256
  • cDNA Data
    12
  • Literature Summary
    143
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000009248 Ensembl Gene Model | MGI Sequence Detail 2436 C57BL/6J ±  kb
    transcript ENSMUST00000009392 Ensembl | MGI Sequence Detail 1605 Not Applicable  
    polypeptide ENSMUSP00000009392 Ensembl | MGI Sequence Detail 263 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 84
      Genomic 30
      cDNA 18
      Primer pair 20
      Other 16

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-12120, MGI:1920948
    References
    more
    • Summaries
      All 217
      Developmental Gene Expression 143
      Gene Ontology 18
      Phenotypes 26
    • Earliest
      J:10529 Bastian H, et al., A murine even-skipped homologue, Evx 1, is expressed during early embryogenesis and neurogenesis in a biphasic manner [published erratum appears in EMBO J 1991 Dec;10(12):3978]. EMBO J. 1990 Jun;9(6):1839-52
    • Latest
      J:345473 Lee JG, et al., PIBF1 regulates trophoblast syncytialization and promotes cardiovascular development. Nat Commun. 2024 Feb 19;15(1):1487
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    10/29/2024
    MGI 6.24     		The Jackson Laboratory