Rab33b MGI Mouse Gene Detail - MGI:1330805 - RAB33B, member RAS oncogene family

Symbol

Rab33b
Name

RAB33B, member RAS oncogene family

Feature Type

protein coding gene
IDs

MGI:1330805
NCBI Gene: 19338
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr3:51391387-51403649 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 22.49 cM, cytoband D
Mapping Data

2 experiments

SNPs within 2kb

338 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1330805	protein coding gene	Chr3:51391341-51403653 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0027198	protein coding gene	Chr3:49961629-49976240 (+)
A/J	MGP_AJ_G0027158	protein coding gene	Chr3:48499518-48511912 (+)
AKR/J	MGP_AKRJ_G0027127	protein coding gene	Chr3:49464515-49478235 (+)
BALB/cJ	MGP_BALBcJ_G0027170	protein coding gene	Chr3:48360046-48377784 (+)
C3H/HeJ	MGP_C3HHeJ_G0026913	protein coding gene	Chr3:49689236-49703150 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027616	protein coding gene	Chr3:51968851-51982679 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024976	protein coding gene	Chr3:45132618-45144448 (+)
CAST/EiJ	MGP_CASTEiJ_G0026366	protein coding gene	Chr3:49756720-49768765 (+)
CBA/J	MGP_CBAJ_G0026890	protein coding gene	Chr3:53590676-53606287 (+)
DBA/2J	MGP_DBA2J_G0027024	protein coding gene	Chr3:48110981-48123349 (+)
FVB/NJ	MGP_FVBNJ_G0026992	protein coding gene	Chr3:47090090-47102884 (+)
LP/J	MGP_LPJ_G0027136	protein coding gene	Chr3:50714615-50727648 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027010	protein coding gene	Chr3:57783451-57795724 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027675	protein coding gene	Chr3:49389008-49401561 (+)
PWK/PhJ	MGP_PWKPhJ_G0026098	protein coding gene	Chr3:47759695-47771823 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025911	protein coding gene	Chr3:49042001-49054117 (+)
WSB/EiJ	MGP_WSBEiJ_G0026440	protein coding gene	Chr3:49495074-49512094 (+)

Human Ortholog

RAB33B, RAB33B, member RAS oncogene family

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RAB33B, RAB33B, member RAS oncogene family
Synonyms

SMC2
Links

HGNC:16075

NCBI Gene ID: 83452

neXtProt AC: NX_Q9H082

UniProt: Q9H082
Chr Location

4q31.1; chr4:139438376-139476609 (+) GRCh38

MGI Vertebrate Homology

Rab33b stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: RAB33B
Gene Tree

Rab33b

Diseases

1 with Rab33b mouse models; 1 with human RAB33B associations

Human Disease

Mouse Models

Smith-McCort dysplasia 2

IDs

View 2 models

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

2 with disease annotations

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Phenotype Summary

16 phenotypes from 2 alleles in 2 genetic backgrounds
17 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Endonuclease-mediated

5
Gene trapped

2
Radiation induced

2
Targeted

3
Genomic Mutations

2 involving Rab33b
Incidental Mutations

Mutagenetix , CvDC
Find Mice (IMSR)

21 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

33
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

57

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rab33b

ZFIN rab33ba

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All Sequences

46
RefSeq

2
UniProt

5
CCDS

CCDS38427.1

Ensembl

ENSMUSG00000027739 (Evidence)
NCBI Gene

19338

			Length	Strain/Species	Flank
genomic	19338	NCBI Gene Model \| MGI Sequence Detail	12263	C57BL/6J	± kb
transcript	NM_016858	RefSeq \| MGI Sequence Detail	3488	C57BL/6
polypeptide	O35963	UniProt \| EBI \| MGI Sequence Detail	229	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000013609 Ras-related protein Rab-33B

(term hierarchy)
PDB

1Z06, 2G77, 6SUR
InterPro Domains

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR041822 Rab33A/B

IPR001806 Small GTPase

IPR005225 Small GTP-binding protein domain

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All nucleic 57

cDNA 57

Microarray probesets 3

Summaries

All 45

Diseases 2

Gene Ontology 10

Phenotypes 17
Earliest

J:64276 Lyon MF, et al., Dose-response curves for radiation-induced gene mutations in mouse oocytes and their interpretation. Mutat Res. 1979 Nov;63(1):161-73
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Rab33b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr29058	Chr3:51391366-51391382 (+)	-13 bp
Tssr29059	Chr3:51391390-51391420 (+)	18 bp
Tssr29060	Chr3:51391605-51391681 (+)	256 bp
Tssr29061	Chr3:51391696-51391725 (+)	324 bp
Tssr29062	Chr3:51391740-51391767 (+)	367 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24