Mrpl23 MGI Mouse Gene Detail - MGI:1196612 - mitochondrial ribosomal protein L23

Symbol

Mrpl23
Name

mitochondrial ribosomal protein L23
Synonyms

L23mrp, Rpl23l

Feature Type

protein coding gene
IDs

MGI:1196612
NCBI Gene: 19935
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr7:142086423-142094484 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 87.95 cM
Mapping Data

15 experiments

SNPs within 2kb

188 from dbSNP Build 142
Strain Annotations

18
PCR

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1196612	protein coding gene	Chr7:142086423-142094484 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0033260	protein coding gene	Chr7:147792917-147800621 (+)
A/J	MGP_AJ_G0033243	protein coding gene	Chr7:143527323-143535027 (+)
AKR/J	MGP_AKRJ_G0033175	protein coding gene	Chr7:147553199-147561156 (+)
BALB/cJ	MGP_BALBcJ_G0033244	protein coding gene	Chr7:143297557-143305496 (+)
C3H/HeJ	MGP_C3HHeJ_G0032959	protein coding gene	Chr7:147313735-147323291 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0033754	protein coding gene	Chr7:153134259-153142036 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030727	protein coding gene	Chr7:144734280-144742048 (+)
CAST/EiJ	MGP_CASTEiJ_G0032282	protein coding gene	Chr7:139624546-139632479 (+)
CBA/J	MGP_CBAJ_G0032930	protein coding gene	Chr7:158383895-158391843 (+)
DBA/2J	MGP_DBA2J_G0033084	protein coding gene	Chr7:141478492-141486428 (+)
FVB/NJ	MGP_FVBNJ_G0033033	protein coding gene	Chr7:141413460-141421583 (+)
LP/J	MGP_LPJ_G0033177	protein coding gene	Chr7:149302781-149310710 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033067	protein coding gene	Chr7:159000063-159007705 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0033773	protein coding gene	Chr7:146501599-146510185 (+)
PWK/PhJ	MGP_PWKPhJ_G0031990	protein coding gene	Chr7:134806104-134814326 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0031836	protein coding gene	Chr7:133301423-133309359 (+)
WSB/EiJ	MGP_WSBEiJ_G0032394	protein coding gene	Chr7:147484298-147492238 (+)

Human Ortholog

MRPL23, mitochondrial ribosomal protein L23

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MRPL23, mitochondrial ribosomal protein L23
Synonyms

L23MRP, RPL23, RPL23L, uL23m
Links

HGNC:10322

NCBI Gene ID: 6150

neXtProt AC: NX_Q16540

UniProt: Q16540
Chr Location

11p15.5; chr11:1947278-2014944 (+) GRCh38

MGI Vertebrate Homology

Mrpl23 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: MRPL23
Gene Tree

Mrpl23

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Phenotype Summary

3 phenotypes from 2 alleles in 2 genetic backgrounds
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

15
Endonuclease-mediated

4
Gene trapped

7
Radiation induced

1
Targeted

3
Genomic Mutations

1 involving Mrpl23
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

19 strains or lines available

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All GO Annotations

15
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

836
Tissues

51
cDNA Data

57
Literature Summary

5

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase mrpl23

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All Sequences

56
RefSeq

12
UniProt

3
CCDS

CCDS22032.1

Ensembl

ENSMUSG00000037772 (Evidence)
NCBI Gene

19935

			Length	Strain/Species	Flank
genomic	19935	NCBI Gene Model \| MGI Sequence Detail	8062	C57BL/6J	± kb
transcript	NM_001417208	RefSeq \| MGI Sequence Detail	654	ZRU/MplStud
polypeptide	O35972	UniProt \| EBI \| MGI Sequence Detail	146	Not Applicable

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UniProt

3 Sequences
InterPro Domains

IPR013025 Large ribosomal subunit protein uL23-like

IPR012677 Nucleotide-binding alpha-beta plait domain superfamily

IPR012678 Ribosomal protein uL23/eL15/eS24 core domain superfamily
GlyGen

O35972 2 sites, 2 N-linked glycans (2 sites)

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All nucleic 78

Genomic 16

cDNA 58

Primer pair 4

Microarray probesets 4

Summaries

All 58

Developmental Gene Expression 5

Gene Ontology 8

Phenotypes 16
Earliest

J:43998 Zubair M, et al., Structure and expression of the mouse L23mrp gene downstream of the imprinted H19 gene: biallelic expression and lack of interaction with the H19 enhancers. Genomics. 1997 Oct 15;45(2):290-6
Latest

J:350560 Tomar A, et al., Epigenetic inheritance of diet-induced and sperm-borne mitochondrial RNAs. Nature. 2024 Jun;630(8017):720-727

TSS for Mrpl23:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr70206	Chr7:142086780-142086791 (+)	363 bp
Tssr2458	Chr7:142086872-142086879 (+)	453 bp
Tssr70207	Chr7:142086881-142086911 (+)	473 bp
Tssr70208	Chr7:142087283-142087310 (+)	874 bp
Tssr70209	Chr7:142088320-142088335 (+)	1,905 bp
Tssr70210	Chr7:142092730-142092738 (+)	6,311 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24