Ccr6 MGI Mouse Gene Detail - MGI:1333797 - C-C motif chemokine receptor 6

Symbol

Ccr6
Name

C-C motif chemokine receptor 6
Synonyms

Cmkbr6

Feature Type

protein coding gene
IDs

MGI:1333797
NCBI Gene: 12458
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr17:8454875-8475973 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 4.90 cM, cytoband A1
Mapping Data

2 experiments

SNPs within 2kb

626 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1333797	protein coding gene	Chr17:8454875-8477353 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0023130	protein coding gene	Chr17:5701054-5724007 (+)
A/J	MGP_AJ_G0023098	protein coding gene	Chr17:5732897-5757403 (+)
AKR/J	MGP_AKRJ_G0023063	protein coding gene	Chr17:5397540-5418502 (+)
BALB/cJ	MGP_BALBcJ_G0023098	protein coding gene	Chr17:5535608-5558821 (+)
C3H/HeJ	MGP_C3HHeJ_G0022861	protein coding gene	Chr17:5672172-5695415 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0023542	protein coding gene	Chr17:5973050-5997424 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021066	protein coding gene	Chr17:8602120-8625343 (-)
CAST/EiJ	MGP_CASTEiJ_G0022376	protein coding gene	Chr17:5654704-5682797 (+)
CBA/J	MGP_CBAJ_G0022833	protein coding gene	Chr17:6175774-6203133 (+)
DBA/2J	MGP_DBA2J_G0022966	protein coding gene	Chr17:5402361-5425610 (+)
FVB/NJ	MGP_FVBNJ_G0022935	protein coding gene	Chr17:5322683-5345949 (+)
LP/J	MGP_LPJ_G0023037	protein coding gene	Chr17:5524560-5547834 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022956	protein coding gene	Chr17:5919233-5942971 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023567	protein coding gene	Chr17:5679310-5700204 (+)
PWK/PhJ	MGP_PWKPhJ_G0022124	protein coding gene	Chr17:5024771-5049343 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0021953	protein coding gene	Chr17:4940498-4963736 (+)
WSB/EiJ	MGP_WSBEiJ_G0022432	protein coding gene	Chr17:5978116-6004582 (+)

Human Ortholog

CCR6, C-C motif chemokine receptor 6

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CCR6, C-C motif chemokine receptor 6
Synonyms

BN-1, C-C CKR-6, CC-CKR-6, CCR-6, CD196, CKR-L3, CKRL3, CMKBR6, DCR2, DRY6, GPR29, GPRCY4, STRL22
Links

HGNC:1607

NCBI Gene ID: 1235

neXtProt AC: NX_P51684

UniProt: P51684
Chr Location

6q27; chr6:167111795-167139141 (+) GRCh38

MGI Vertebrate Homology

Ccr6 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: CCR6
Gene Tree

Ccr6

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References

6 with disease annotations

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Phenotype Summary

58 phenotypes from 6 alleles in 9 genetic backgrounds
1 images
469 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

13
Endonuclease-mediated

5
Radiation induced

1
Targeted

7
Genomic Mutations

1 involving Ccr6
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

37 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice have decreased inflammatory responses, aberrant trafficking of lymphocytes and dendritic cells, and decreased expression of many inflammatory mediators.

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All GO Annotations

51
GO References

14

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

910
Tissues

82
cDNA Data

13
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN ccr6a, ccr6b

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All Sequences

83
RefSeq

32
UniProt

5
CCDS

CCDS28381.1

Ensembl

ENSMUSG00000040899 (Evidence)
NCBI Gene

12458

			Length	Strain/Species	Flank
genomic	ENSMUSG00000040899	Ensembl Gene Model \| MGI Sequence Detail	21099	C57BL/6J	± kb
transcript	ENSMUST00000164411	Ensembl \| MGI Sequence Detail	1398	Not Applicable
polypeptide	ENSMUSP00000131153	Ensembl \| MGI Sequence Detail	367	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000001202 C-C chemokine receptor type 6

(term hierarchy)
InterPro Domains

IPR004067 CC chemokine receptor 6

IPR000355 Chemokine receptor family

IPR017452 GPCR, rhodopsin-like, 7TM

IPR050119 G-protein coupled receptor 1

IPR000276 G protein-coupled receptor, rhodopsin-like
GlyGen

O54689 2 sites

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All nucleic 16

Genomic 1

cDNA 14

Primer pair 1

Microarray probesets 3

Summaries

All 528

Developmental Gene Expression 4

Diseases 6

Gene Ontology 14

Phenotypes 469
Earliest

J:30229 Davisson MT, et al., Segmental trisomy as a mouse model for Down syndrome. Prog Clin Biol Res. 1993;384:117-33
Latest

J:354984 Emili M, et al., Reversal of neurodevelopmental impairment and cognitive enhancement by pharmacological intervention with the polyphenol polydatin in a Down syndrome model. Neuropharmacology. 2024 Sep 27;261:110170

TSS for Ccr6:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr142517	Chr17:8454863-8454878 (+)	-4 bp
Tssr142518	Chr17:8454893-8454907 (+)	25 bp
Tssr142519	Chr17:8454939-8454950 (+)	70 bp
Tssr142520	Chr17:8457162-8457169 (+)	2,291 bp
Tssr142521	Chr17:8463871-8463882 (+)	9,002 bp
Tssr142522	Chr17:8463886-8463924 (+)	9,030 bp
Tssr142523	Chr17:8474883-8474888 (+)	20,011 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/05/2024 MGI 6.24